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Authors
Affiliations
1 Lecturer Ph. D. Department of Pharmacy, Al-Israa University, Baghdad, IQ
2 Assist Prof. Dr. Department of Chemistry and Biochemistry, College of Medicine, Al-Nahrain University, Baghdad, IQ
3 Assist Prof. Dr. Department of Pediatric, College of Medicine, Al-Nahrain University, Baghdad, IQ
Source
Indian Journal of Public Health Research & Development, Vol 11, No 2 (2020), Pagination: 2422-2427
Abstract
One of the most important parameters to evaluate severity and type of cholestasis disease is gamma-glutamyl transferase and citrin protein measurements. The objective of this study was to assess the clinical value of serum citrin protein with gamma-glutamyl transferase in children with cholestasis. 60 subjects with diseases and 25 healthy subjects distributed intothree groups, citrinand gamma-glutamyl transferasewere measured for all case and control studies by enzyme linked immunosorbent Assay. The results showed serum citrin has a highly significantly decreased in an intra- and extrahepatic cholestasis groups when compared with control (P<0.001), serum gamma-glutamyl transferasehas a highly significantly elevated in an intrahepatic cholestasis group when compared with control (P<0.003). From these findings it was concluded that serum gamma-glutamyl transferase level is a good marker in determining the severity of cholestasis disease, serum citrin may be useful in future to diagnose the cholestasis caused by citrin deficiency.
Keywords
γ-Glutamyl transferase (GGT), Biliary atresia (BA), Alagille syndrome (AGS), Progressive familial intrahepatic cholestasis (PFIC), Idiopathic neonatal hepatitis (INH), Citrin deficiency (CD).
