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Jayshree, N.
- A Review on Hybanthus enneaspermus
Authors
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 7, No 4 (2015), Pagination: 245-249Abstract
Hybanthus enneaspermus belonging to the family Violaceae commonly known as spade flower, is a small shrub growing to a height of 60cm with pink-purple spade shaped flowers. Ionidium suffriticosum, Viola suffriticosa, Ionidium enneaspermum and Viola enneaspermum are the synonyms for the plant. Entire plant is of medicinal importance and is widely used in Ayurveda and Siddha systems of medicine. Dipeptide, alkaloids, aurantiamide acetate, isoarborinol, sitosterol, sugars, flavonoids, catechins, tannins, anthraquinones and amino acids are the constituents present in the plant. In Southwest Nigeria the plant is locally known as Abiwere, used by Traditional birth attendants to make delivery less laborious. Hybanthus enneaspermus shows interesting medicinal properties like anti-hyperlipidemic activity, free radical scavenging activity, nephro protective activity, antioxidant activity, anti-arrhythmic activity, anti-infertility activity, anti-allergic, analgesic activity and anti-microbial activity. This article as a review on the plant, its phytochemistry and its reported pharmacological activity.Keywords
Hybanthus enneaspermus, Violaceae, Pharmacognosy, Phytochemistry, Pharmacology.- Pharmacognostical Standardization of Leaves of Ravenala madagascariensis Sonn.
Authors
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, Tamilnadu, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 4 (2010), Pagination: 288-292Abstract
Standardization was carried out on the basis of detailed botanical evaluation of the leaves which includes morphology and microscopy as well as WHO recommended physico-chemical studies. The results of the standardization may throw a immense light on the botanical identity of the leaves Ravenala madagascariensis Sonn., which may furnish a basis of judging the authenticity of the plant and also to differentiate the drug from its adulterants and other species.
Ravenala madagascariensis Sonn., (Strelitziaceae), also known as Visirivazhai in Tamil, is a native of Madagascar, widely cultivated for its distinctive habit in tropical and subtropical regions. In addition to its ornamental nature, this tree has been widely used in traditional medicine for the treatment of diabetes and kidney stone problems. The seeds are reported to be antiseptic. The leaves of Ravenala madagascariensis Sonn., have close resemblance with Musa leaf. Hence pharmacognostical standardization will contribute to the differentiation of Ravenala madagascariensis Sonn. leaves from that of Musa paradisiaca. The anatomy of leaf showed squarish upper epidermis. The lower epidermis was stomatiferous. Cyclocytic stomata, druses, raphides, mesophyll with tannin bodies, lobed sclereids remain the characteristic features of the leaf microscopy. Physicochemical parameters were evaluated and fluorescence analysis were carried out.
Thus the study employs the correct identification of standardization of the drug in crude form.
Keywords
Ravenala madagascariensis Sonn., Standardization, Botanical, Physico-Chemical Constants.- Pharmacological Evaluation of Polyherbal Formulation for Nephroprotective Activity
Authors
1 R&D Centre, Rumi Herbals Private Limited, Chennai – 600095, Tamil Nadu, IN
2 Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur – 603203, Tamil Nadu, IN
3 Department of Pharmacology, College of Pharmacy, Madras Medical College, Chennai – 600003, Tamil Nadu, IN
4 Department of Pharmacology, Captain Srinivasa Murthy Regional Ayurveda Drug Development Institute, Chennai – 600106, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 22, No 3 (2022), Pagination: 393 - 411Abstract
The kidney plays an essential role in removing waste products and drugs from the body and maintaining balanced body fluids. It gets affected due to many factors, notably, diabetes and high blood pressure. Nowadays, naturally, derived products are essential in curing various ailments and are safe and cost-effective. The purpose of this study is to assess the toxicity profile and nephroprotective effect of a proprietary polyherbal formulation in Wistar albino rats for gentamicin-induced nephrotoxicity. The Polyherbal formulation was procured from Rumi Herbals Private Limited. Acute toxicity experiments were conducted in Wistar rats using the Gentamicin induced nephrotoxicity model as per OECD standards 423, and the efficacy was assessed using the Gentamicin induced nephrotoxicity model. The formulation was proven safe up to 2000mg/ kg orally in an acute toxicity study, with no behavioral abnormalities and no fatality. The gentamicin 80 mg/kg i.p for 7 days induced nephrotoxicity in rats showed a significant (P<0.05) increase in the renal parameters and reduction in antioxidant levels compared with day 0. Whereas test drug-treated groups at a low dose (200 mg/kg) and high dose (400 mg/kg) showed significant (P<0.05) reduction in elevated renal parameters and improvement in antioxidant levels compared with the disease control group. According to the histopathological interpretation of isolated kidneys, this formulation protects from kidney damage and restores typical kidney architecture. From the results, the proprietary polyherbal formulation has shown effective nephroprotective activity may be due to the presence of secondary metabolites/phytoconstituents. Further investigation is essential to focus on the mechanism involved and standardize the active phytoconstituents responsible for the nephroprotective activity.
Keywords
Acute Toxicity, Antioxidant, Gentamicin, Nephroprotective, Polyherbal Formulation.References
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