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Alkananda Sahoo ¹, Swagatika Panda ¹, Subrat Padhiary ², Neeta Mohanty ¹, Debkant Jena ³

Affiliations
1 Department of Oral and Maxillofacial Pathology and Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
2 Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
3 Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha,, IN

Abstract

Jaffe in 1953 differentiated Central Giant Cell Granuloma (CGCG) from Giant Cell Tumor of bone. This intra-osseous lesion has been described by various authors’ as a reactive lesion or as a developmental anomaly or as a non neo-plastic lesion. Though inflammation, haemorrhage, local trauma has been suggested as some of the aetiological factors but actual aetiology is still unclear. Genetic aetiology has also been hypothesized. Mandible is the common site of occurrence, frequently crossing the midline. Incidences in females are more and less than 30 is the age of occurrence. The clinical behaviour of CGCG ranges from a slowgrowing asymptomatic swelling to an aggressive lesion with pain, local osteolysis, ischolar_main resorption and tooth displacement. Most widely accepted treatment is surgery. Nonsurgical treatments with alpha-interferon, calcitonin and corticosteroids have been described and their benefits may be worthy of consideration. Contrary to the age, gender and site here we present a case of CGCG in a 52-year-old male patient presenting with a swelling in the right anterior maxilla.

Keywords

Central Giant Cell Granuloma, Swelling, Maxilla.

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Neeta Mohanty ¹, Shubhangi Pareek ¹, Sreepreeti Champatyray ¹

Affiliations
1 Department of Oral and Maxillofacial Pathology and Microbiology, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN

Abstract

Nasopalatine duct cyst is the most commonly encountered epithelial non odontogenic cyst of the maxilla. Epithelial remnants of the nasopalatine duct triggered due to some sort of irritation in the form of infection or spontaneously may give rise to Nasopalatine duct cyst. The final diagnosis can only be made based upon the clinical, radiological and most importantly histopathological findings. Treatment strategies mainly incorporate enucleation of the lesion followed by marsupialization as indicated in some cases. We present here a case of Nasopalatine duct cyst in a 45-year-old male which was diagnosed clinically as dentigerous cyst in association with an impacted tooth but a conclusive diagnosis of nasopalatine duct cyst was finally made based upon the histopathological findings.

Keywords

Nasopalatine Duct Cyst, Marsupialization, Histopathology, Radiology.

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Devi Prasad Mandal ¹, Neeta Mohanty ¹

Affiliations
1 Department of Oral Pathology & Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN

Abstract

Head and neck squamous cell carcinoma are usually associated with multiple premalignant lesions. This is derived from the idea of field effect in cancer. The concept of “FIELD CANCERIZATION” was introduced by Slaughter et al in 1953 while studying the presence of histologically altered tissue adjacent to oral squamous cell carcinoma (OSCC) cases. It explains the initiation of several primary tumours and locally recurrent cancer. Advance technology and cautious study design using suitable control is helpful in detection of important molecular biomarkers in genetically transmuted but histologically normal cells. These tumor specific biomarkers should improve clinical implications and effectiveness in early diagnosis and treatment modalities. In this review we discuss the perception, clinical implications and effectiveness of field cancerization in head and neck squamous cell carcinoma.

Keywords

Field Cancerization, Head and Neck Squamous Cell Carcinoma.

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Swagatika Panda ¹, Sreepreeti Champatyray ¹, Alkananda Sahoo ¹, Neeta Mohanty ²

Affiliations
1 Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar. Odisha, IN
2 Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar. Odisha, IN

Abstract

Focal cemento-osseous dysplasia (FCOD) is a fibro-osseous lesion that is a nonneoplastic reactive lesion. Fibro-osseous lesions are disturbances in bone metabolism in which normal bone is replaced by a connective tissue matrix that then gradually develops into cemento-osseous tissue. Typically, the lesion is asymptomatic and is detected on routine radiographic examination. Radiologically, this lesion has three stages of maturation: pure radiolucent, radiopaque/mixed radiolucent, and radiopaque appearance. During these stages the lesion can be misdiagnosed. In this case report a 57-year- old patient complaint of painless swelling of the right mandibular front tooth region which is presented along with a review of the differential diagnosis considered in order to reach a final diagnosis of focal cemento-osseous dysplasia.

Keywords

Cemento-Osseous Dysplasia, Fi Bro-Osseous Lesion, Focal Cemento-Osseous Dysplasia, Periapical Cemento-Osseous Dysplasia.

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Satya Ranjan Misra ¹, Swagatika Panda ², Subrat Padhiary ³, Subhangi Pareek ², Saswati Priyadarshini ¹, Neeta Mohanty ²

Affiliations
1 Department of Oral Medicine & Radiology, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
2 Department of Oral Pathology & Microbiology, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
3 Department of Oral Surgery, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN

Abstract

Dentinogenic ghost cell tumor DGCT) is a rare, locally invasive and aggressive, benign odontogenic neoplasm which is considered to be a solid variant of calcifying odontogenic cyst COC) with locally aggressive behavior.These resemble other epithelial odontogenic tumors having proliferation of odontogenic epithelium, an abnormal keratinization in the form of ghost cells and dysplastic dentine. There are no characteristic clinical or radiologic pathognomonic features of this rare neoplasm and is confirmed by histopathological evaluation. The present report describes an extremely rare presentation of a DGCT in the posterior body-ramus of the mandible of a 13-year-old male child, which is an unusual age of occurrence.

Keywords

Calcifying Odontogenic Cyst, Dentine, Ghost Cells, Aggressive Tumor.

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Shubhangi Pareek ¹, Swagatika Panda ², Tariq Soyab ³, Anurag Satpathy ⁴, Rashmita Nayak ⁴, Neeta Mohanty ²

Affiliations
1 Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
2 Department of Oral and Maxillofacial Pathology and Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
3 Institute of Dental Sciences, Department of Oral and Maxillofacial Pathology and Microbiology, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
4 Department of Periodontics and Implantology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN

Abstract

Oral Verruciform xanthoma (OVX) is a benign mucocutaneous, rare, asymptomatic lesion of unknown etiology and ambiguous nature involving the oral mucous membrane of the middle-aged during the fifth to seventh decadeof life. Clinically it may be presented as a verrucous, polyploid or sessile mass mostly solitary and slow growing in the hard palate,gingival, tongue or buccal mucosa. Colour of the lesion may vary from white, pink or red and there is a slight male predilection. The histopathological features of OVX are however pathognomonic, characterized by the presence of lipid- laden foam cells confined to the papillary areas of connective tissue. The final diagnosis is always histopathological as its clinical features are not distinct and OVX must always be considered in the differential diagnosis of other verrucous and papillary lesions. Treatment of OVX is complete surgical excision with follow up to avoid its recurrence. We present2 cases of oral verruciform Xanthoma, which were provisionally misdiagnosed as pyogenic granuloma and traumatic fibroma respectively based upon their clinical presentation and after a thorough histopathological examination revealed an entirely different diagnosis in both the cases.

Keywords

Oral Verruciform Xanthoma, OVX, Mucocutaneous Lesion, Foam Cells.

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Swagatika Panda ¹, Saswati Sidharatha ¹, Neeta Mohanty ²

Affiliations
1 Institute of Dental Sciences, Siksha‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
2 Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN

Abstract

This report has described a case of central odontogenic fibroma coexisting with inflammatory odontogenic cyst for the second time in the literature. The case describes a 48-year-old female presented with swelling and intermittent pain in the upper left posterior teeth region. Mobile maxillary left second premolarwas found to be associated with a well-defined unilocular radiolucency and ischolar_main resorption. Histopathology showed collagenous connective tissue and odontogenic epithelial cells arranged in the form of nests and cords. Along with the conventional features of central odontogenic fibroma an inflammatory cyst was also found. Therefore, the case of central odontogenic fibroma coexisting with inflammatory odontogenic cyst shall be discussed in this report highlighting the possible aetiopathogenesis and prognosis of such lesions.

Keywords

Odontogenic Fibroma, Central Odontogenic Fibroma. Odontogenic Fibroma, Central Odontogenic Fibroma.

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Neeta Mohanty ¹, Jay Gopal Roy ², Sayani Dutta ³

Affiliations
1 Department of Oral and Maxillofacial Pathology and Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
2 Department of Oral Pathology & Oral Medicine & Radiology, Burdwan Dental College & Hospital, Bardhaman, West Bengal, IN
3 Department of Oral & Maxillofacial Pathology, Dr. R. Ahmed Dental College & Hospital, Kolkata, West Bengal, IN

Abstract

The squamous odontogenic tumour (sOT) is a rare, benign epithelial neoplasm of odontogenic apparatus that appears to originate from the rests of Malassez, remnants of the dental lamina or gingival epithelium. From its first documentation in 1975, Since then there is limited number of reported cases, especially in the Indian subcontinent. We report three cases of SOT with varied clinicopathological presentation and management. The first two cases presented as asymptomatic swellings in maxilla whereas the third one was in body of mandible. Variable radiographic picture ranging from well-defined radiolucency to mixed radiolucent-radiopacity was noticed among the three cases. All cases responded well to the conventional treatment therapy.

Keywords

Squamous Odontogenic Tumor, Benign Neoplasm, Radiolucency, Histopathology, Conventional Treatment.

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Devi Prasad Mandal ¹, Neeta Mohanty ²

Affiliations
1 Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
2 Department of Oral & Maxillofacial Pathology & Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN

Abstract

Adenoid cystic carcinoma is an uncommon salivary gland tumor with high rate of recurrence and metastasis. The unpredicted clinical course is countered-back by regular clinical follow-up for at least >15 years. The traditional treatment protocol is surgery with postoperative radiotherapy to optimize local metastasis. Research has been carried out to understand the molecular biological process of the tumor that can cure the patients at high risk of recurrence. This article presents a case of sub-mandibular gland malignant neoplasm of a 34 years male patient.

Keywords

Adenoid Cystic Carcinoma (ACC), Salivary Gland Neoplasm.

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Jagannath Patro ¹, Swagatika Panda ¹, Sreepreeti Champatyray ¹, Alkananda Sahoo ¹, Neeta Mohanty ¹

Affiliations
1 Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan, Deemed to be University, Bhubaneswar, Odisha, IN

Abstract

Dentigerous cyst is the most commonly occurring developmental odontogenic cyst. Because of the typical clinical and radiologic attributes, the present case was clinically misdiagnosed as Dentigerous cyst which was later confirmed histopathologically as Lateral periodontal cyst. Lateral periodontal Cyst is defined as non-keratinized developmental cyst located lateral to the ischolar_main of a vital tooth. This case report presents a unique case of lateral periodontal cyst present in 58-year-old female patient. Atypical presentation of lateral periodontal cyst as is presented in this case report should be considered by the histopathologist while interpreting microscopic preparations of odontogenic cysts.

Keywords

Lateral Periodontal Cyst, Dentigerous Cyst, Histopathology, Orthopantomograph.

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