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Joshi, Niharika
- Association of Socio-personal Factors with the Subjective Well-being of Infertile Women
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Authors
Affiliations
1 Department of Human Development, Punjab Agricultural University, Ludhiana, IN
1 Department of Human Development, Punjab Agricultural University, Ludhiana, IN
Source
Indian Journal of Health and Wellbeing, Vol 5, No 6 (2014), Pagination: 715-717Abstract
Infertility is a growing problem which is affecting a significant number of individuals. It is not a stable trait but a process with an uncertain trajectory. Infertility has a significant impact on subjective well-being which is a self evaluation of well-being. Since social and personal factors affects the well-being of an individual, therefore studying about them can help to gain a deeper understanding of infertility experience of women. The present study is an attempt to study the association of socio-personal factors with the subjective well-being of infertile women of Ludhiana district. The study was based on a sample of 180 infertile women (90 rural and 90 urban). Socio-personal profile was assessed by a Self- Structured Interview Schedule and subjective well-being was assessed by using Subjective well-being Inventory developed by Nagpal and Sell (1985). Results revealed that socio-personal factors like age, educational qualification, occupational status, family type, duration of infertility are significantly associated with the subjective well-being of the respondents.Keywords
No Keywords- Association of Socio-Personal Factors with the Defense Mechanisms Used by Infertile Women
Abstract Views :374 |
PDF Views:0
Authors
Affiliations
1 Department of Human Development, Punjab Agricultural University, Ludhiana (Punjab), IN
1 Department of Human Development, Punjab Agricultural University, Ludhiana (Punjab), IN
Source
Asian Journal of Home Science, Vol 10, No 2 (2015), Pagination: 278-284Abstract
Parenting is viewed by most of the couples as their central role in life, and the thought of not achieving it can be very upsetting. Infertility is a stressor that often taxes a couple's personal and relational resources such that defense mechanisms are a natural outgrowth of the experience. Social and personal factors play a huge role in an individuals' life and studying their association with the defense mechanisms can help to gain a deeper understanding of infertility experience of women. The present study is an attempt to explore the association between socio-personal factors and defense mechanisms used by rural and urban infertile women of Ludhiana district. The study was based on a sample of 180 infertile women (90 rural and 90 urban). Socio-personal profile was assessed by using self- structured Interview Schedule. Defense mechanisms were explored by using Defense Mechanisms Inventory by Mrinal and Singhal (1984). Results revealed that there is a non-significant difference in the use of defense mechanisms as per the socio-economic strata of the respondents. It was also revealed that socio-personal factors like duration of infertility and educational qualification are significantly associated (p<0.01) with principalization and the defense turning against self is significantly associated with family type and working status of the respondents.Keywords
Socio-Personal Factors, Defense Mechanisms, Infertile Women.References
- Benyamini, Y., Gozlan, M. and Kokia, E. (2009). Women’s and men’s perception of infertility and their associations with psychological adjustment: a dyadic approach. Br. J. Health Psychol., 14 : 1–16.
- Boivin, J. and Schmidt, L. (2005). Infertility related stress in men and women predicts treatment outcome 1 year later. Fertil. Steril., 83 : 1745–1752.
- Gourounti, K., Anagnostopoulos, F. and Vaslamatzis, G. (2010). Primary appraisal of infertility. Evaluation of the psychometric properties of a Greek version of the Appraisal of Life Events scale (ALE) in a sample of infertile women undergoing fertility treatment. Women Health, 50 : 688–704.
- Iyengar, K. and Iyengar, S. (1999). Dealing with infertility: Experiences of reproductive health program in Southern Rajasthan. National consultation on infertility prevention and management UNFPA, New Delhi(INDIA).
- Lazarus, R. and Folkman, S. (1984). Stress, appraisal and coping. Springer Publications, New York.
- Leventhal, H., Meyer, D. and Nerenz, D. (1980). The Common Sense Representation of Illness Danger. In: Rachman, S. (Ed.), Medical Psychology, vol. 2. Pergamon Press, New York, pp. 7–30.
- Lord, S. and Robertson, N. (2005). The role of patient appraisal and coping in predicting distress in IVF. J. Reprod. Inf. Psychol., 23 : 319–332.
- Mahajan, N., Turnbull, D., Davies, M., Jindal, U., Briggs, N. and Taplin, J. (2009). Adjustment to infertility: the role of intrapersonal and interpersonal resources/vulnerabilities.Hum. Reprod., 24 : 906–912.
- Miles, L., Keitel, M., Jackson, M., Harris, A. and Licciardi, F., (2008). Predictors of distress in women being treated for infertility. J. Reprod. Inf. Psychol., 27 : 238–257.
- Morady, F. (2001). The study of marital satisfaction in couples. Iranian J. Reprod Med., 2 : 46–51.
- Mrinal, N. and Singhal, U. (1984). Defense Mechanism Inventory. National Psychological Corporation, Agra (U.P.) INDIA.
- Nelson, A. and Gellar, P. (2011). Coping with fertility treatment: Infertility-related stress and social support among women receiving in vitro fertilization. Gender Medicine, 9 : 11-14.
- Van den Broeck, U., D’Hooghe, T., Enzlin, P. and Demyttenaere, K. (2010). Predictors of psychological distress in patients starting IVF treatment: infertility-specific versus general psychological characteristics. Hum. Reprod., 25 : 1471–1480.
- Verhaak, C.M., Smeenk, J.M.J., Evers, A.W.M., van Minnen, A., Kremer, J.A.M. and Kraaimaat, F.W. (2005a). Predicting emotional response to unsuccessful fertility treatment, a prospective study. J. Behav. Med., 28 : 181–190.
- Verhaak, C.M., Smeenk, J.M.J., van Minnen, A., Kremer, J.A.M., Kraaimaat, F.W. (2005b). A longitudinal, prospective study on emotional adjustment before, during and after consecutive fertility treatment cycles.Hum. Reprod., 20 : 2253–2260.
- Verhaak, C.M., Smeenk, J.M.J., Evers, A., Kremer, J., Kraaimaat, F. and Braat, D. (2007). Women’s emotional adjustment to IVF: a systematic review of 25 years of research. Hum. Reprod. Update, 13 : 27–36.
- WHO (2004). The WHO Report. Mental Health News Understanding. New Hope. Geneva. 27–30.
- Assessment of Anxiolytic Activity of Brahmi (Bacopa monnieri) in Zebrafish Model System
Abstract Views :144 |
PDF Views:71
Authors
Padmshree Mudgal
1,
Radhika Gupta
1,
Adita Joshi
2,
Chandhana Prakash
1,
Kajal Gupta
1,
Ritika Sachdeva
1,
Niharika Joshi
1
Affiliations
1 Department of Biochemistry, Daulat Ram College, University of Delhi, Delhi - 110007, IN
2 Sansriti Foundation, Delhi - 110016, IN
1 Department of Biochemistry, Daulat Ram College, University of Delhi, Delhi - 110007, IN
2 Sansriti Foundation, Delhi - 110016, IN
Source
Journal of Natural Remedies, Vol 23, No 2 (2023), Pagination: 661-670Abstract
The increasing prevalence of anxiety and stress-related disorders has made it a leading contributor to the global health burden. The present treatment options have severe side effects and show remission on discontinuation of the medication. Hence, there is an urgent need to explore safer alternative treatments for long-term usage with minimum toxicity. The medicinal plant Brahmi (Bacopa monnieri) has been used in Indian traditional medicine as a neural tonic for centuries. The present study aimed to study the toxicity and anxiolytic activity of Brahmi using the zebrafish model system. The toxicity assays determined the minimum effective concentration of Brahmi to be 0.01%. In addition, behavioral assays such as thigmotaxis and scototaxis and endocrine assays such as the measurement of cortisol levels in stressed zebrafish larvae were performed. Zebrafish embryos exposed to 0.2% Brahmi up to seven days post fertilization (dpf) did not show any developmental toxicity. Behavioral and endocrine assays were performed on 5dpf zebrafish larvae treated with 0.01% Brahmi extract. Our studies show that Brahmi significantly reduced thigmotaxis (wall hugging) and scototaxis behavior in zebrafish larvae exposed to osmotic stress as compared to untreated stressed larvae. Stress activates the hypothalamic-pituitary-interrenal axis and stimulates the release of cortisol in zebrafish larvae. Whole body cortisol assay has shown that Brahmi significantly reduced the stress-induced release of cortisol in zebrafish larvae. Our studies report that Brahmi mitigates the stress response in zebrafish larvae and has minimum toxicity. This suggests that Brahmi may be a safe option for long term management of stress.Keywords
Cortisol, HPI Axis, Scototaxis, Stress, Thigmotaxis.References
- Collaborators C-MD. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. Lancet. 2021; 398(10312):1700-12. https://doi.org/10.1016/S0140-6736(21)02143-7
- WHO. COVID-19 pandemic triggers 25% increase in prevalence of anxiety and depression worldwide. 2022 [Available from: https://www.who.int/news/item/02-03-2022-covid-19-pandemic-triggers-25-increase-in-prevalence-of-anxiety-and-depression-worldwide]
- Rogers AH, Wieman ST, Baker AT. Anxiety comorbidities: Mood disorders, substance disorders, and chronic mental illness. Bui E, Charney ME, Baker AW, editors: Humana / Springer Nature; 2020; 77-103. https://doi.org/10.1007/978-3-030-30687-8_5
- Bandelow B, Michaelis S, Wedekind D. Treatment of anxiety disorders. Dialogues Clin Neurosci. 2017; 19(2):93-107. https://doi.org/10.31887/DCNS.2017.19.2/bbandelow
- Garakani A, Murrough JW, Freire RC, Thom RP, Larkin K, Buono FD, et al. Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options. Front Psychiatry. 2020. https://doi.org/10.3389/fpsyt.2020.595584
- Lader M. Long-term anxiolytic therapy: the issue of drug withdrawal. J Clin Psychiatry. 1987; 48:12-6. PMID: 2891684.
- Medicines CoSo. Selective serotonin reuptake inhibitors (SSRIs) and serotonin and reuptake inhibitors (SNRIs): use and safety. Medicines and Healthcare products Regulatory Agency (MHRA). 2014. [Available at: https://www.gov.uk/government/publications/ssris-and-snris-use-and-safety/selective-serotonin-reuptake-inhibitors-ssris-and-serotonin-and-noradrenaline-reuptake inhibitors-snris-use and-safety].
- George TT, Tripp J. Alprazolam: StatPearls Publishing. 2022. [Available from: https://www.ncbi.nlm.nih.gov/books/NBK538165/].
- Parsaik AK, Mascarenhas SS, Khosh-Chashm D, Hashmi A, John V, Okusaga O, et al. Mortality associated with anxiolytic and hypnotic drugs-A systematic review and meta-analysis. Aust N Z J Psychiatry. 2016; 50(6):520-33. https://doi.org/10.1177/0004867415616695
- Ezzat SM, Jeevanandam J, Egbuna C, Kumar S, Ifemeje JC. Phytochemistry: An in-silico and in-vitro Update. Kumar S, Egbuna C, editors. 2019. Phytochemistry: An in-silico and in-vitro Update. Springer, Singapore. https://doi.org/10.1007/978-981-13-6920-9_1
- Basu N, Rastogi R, Dhar ML. Chemical examination of Bacopa mienniera wettst: part III-bacoside B. Ind J Chem. 1967; 5:84-95.
- Bhattacharya SK, Ghosal S. Anxiolytic activity of a standardized extract of Bacopa monniera: an experimental study. Phytomedicine. 1998; 5:77-82. https://doi.org/10.1016/S0944-7113(98)80001-9
- Chowdhuri DK, Parmar D, Kakkar P, Shukla R, Seth PK, Srimal RC. Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain. Phytother Res. 2002; 16(7):639-45. https://doi.org/10.1002/ptr.1023
- Mannan M. Anxiolytic Effects of the Methanolic Extract of Bacopa monniera in Mice. Pharmacol. Pharm. 2019; 10:298-308. https://doi.org/10.4236/pp.2019.106024
- Singh HK, Shanker G, Patnaik GK. Neuropharmacological and anti-stress effects of bacosides: A memory enhancer. Ind J Pharmacol. 1996; 28:47
- Sheikh N, Ahmad A, Siripurapu KB, Kuchibhotla VK, Singh S, Palit G. Effect of Bacopa monniera on stress-induced changes in plasma corticosterone and brain monoamines in rats. J Ethnopharmacol. 2007; 111(3):671-6. https://doi.org/10.1016/j.jep.2007.01.025
- Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, et al. The zebrafish reference genome sequence and its relationship to the human genome. Nature. 2013; 496(7446):498-503. https://doi.org/10.1038/nature12111
- OECD guidelines for the testing of chemicals, Fish Embryo Acute Toxicity (FET) Test. OECD. 2013. https://doi.org/10.1787/9789264203709-en
- Stewart AM, Braubach O, Spitsbergen J, Gerlai R, Kalueff AV. Zebrafish models for translational neuroscience research: from tank to bedside. Trends Neurosci. 2014; 37(5):264-78. https://doi.org/10.1016/j.tins.2014.02.011
- Kalueff AV, Gebhardt M, Stewart AM, Cachat JM, Brimmer M, Chawla JS, et al. Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond. Zebrafish. 2013; 10:70-86. https://doi.org/10.1089/zeb.2012.0861
- McCarty R. Learning about stress: neural, endocrine and behavioral adaptations. Stress. 2016; 19(5):449-75. https://doi.org/10.1080/10253890.2016.1192120
- Demin KA, Taranov AS, Ilyin NP, Lakstygal AM, Volgin AD, de Abreu MS, et al. Understanding neurobehavioral effects of acute and chronic stress in zebrafish. Stress. 2021; 24(1):1-18. https://doi.org/10.1080/10253890.2020.17249 48
- de Abreu MS, Demin KA, Giacomini A, Amstislavskaya TG, Strekalova T, Maslov GO, et al. Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals. Neurobiol Stress. 2021; 15:100405. https://doi.org/10.1016/j.ynstr.2021.100405
- Gupta R, Ranjan S, Yadav A, Verma B, Malhotra K, Madan M, et al. Toxic Effects of Food Colorants Erythrosine and Tartrazine on Zebrafish Embryo Development. Curr Res Nutr Food Sci. 2019; 7(3). https://doi.org/10.12944/CRNFSJ.7.3.26
- Schnorr SJ, Steenbergen PJ, Richardson MK, Champagne DL. Measuring thigmotaxis in larval zebrafish. Behav Brain Res. 2012; 228(2):367-74. https://doi.org/10.1016/j.bbr.2011.12.016
- Clark KJ, Boczek NJ, Ekker SC. Stressing zebrafish for behavioral genetics. Rev Neurosci. 2011; 22(1):49-62. https://doi.org/10.1515/rns.2011.007
- Bai Y, Liu H, Huang B, et al. Identification of environmental stressors and validation of light preference as a measure of anxiety in larval zebrafish. BMC Neurosci. 2016; 17(63). https://doi.org/10.1186/s12868-016-0298-z
- Yeh CM, Glock M, Ryu S. An optimized whole-body cortisol quantification method for assessing stress levels in larval zebrafish. PLoS One. 2013; 8(11):e79406. https://doi.org/10.1371/journal.pone.0079406
- Brimson JM, Brimson S, Prasanth MI, Thitilertdecha P, Malar DS, Tencomnao T. The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data. Sci Rep. 2021; 11(1):596. https://doi.org/10.1038/s41598-020-80045-2
- Sireeratawong S, Jaijoy K, Khonsung P, Lertprasertsuk N, Ingkaninan K. Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats. BMC Complement Altern Med. 2016; 16:249. https://doi.org/10.1186/s12906-016-1236-4
- Singh HK, Dhawan BN. Neuropsychopharmacological effects of the Ayurvedic Bacopa monniera Linn. (Brahmi) Indian J Pharmacol. 1997; 29:359-65. https://doi.org/10.1089/rej.2013.1431.
- Nathan PJ, Clarke J, Lloyd J, Hutchison CW, Downey L, Stough C. The acute effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy normal subjects. Hum Psychopharmacol. 2001; 16(4):345-51. https://doi.org/10.1002/hup.306
- Basnet RM, Zizioli D, Taweedet S, Finazzi D, Memo M. Zebrafish Larvae as a Behavioral Model in Neuropharmacology. Biomedicines. 2019; 7(1). https://doi.org/10.3390/biomedicines7010023
- Wendelaar Bonga SE. The stress response in fish. Physiol Rev. 1997; 77(3):591-625. https://doi.org/10.1152/phys-rev.1997.77.3.59