A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Panda, Niranjan
- Wound Healing Activity of Poly Herbal Formulation
Authors
1 Pharmacology Research Lab, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad-50001, Telangana, IN
2 Almocare Herbal and Ayurvedic Clinic, Chirag Ali lane, Abids, Hyderabad, Telangana, IN
3 Department of Pharmaceutics, Anwarululoom College of Pharmacy, New Mallepally, Hyderabad-50001, Telangana, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 2 (2015), Pagination: 125-128Abstract
Aim: To evaluate the Wound healing potential of a Poly herbal formulation.
Material and Methods: In the present work a poly herbal Unani formulation; beeswax (base), sesame oil (10%), olive oil (10%), honey (20%), psoraleac (5%), borax (10%), arnica (5%) and curcuma longa (1%) were used and the wound healing potential was determined by both excision and incision wound healing models. Albino wistar rats were used for this purpose. The wound area in excision wound model and tensile strength in incision wound model were determined. Histopathological studies were also carried out to determine the phases of wound healing.
Results: From the results obtained it was evident that the PUF has shown wound healing activity in both excision and incision wound models. In the EWM the beneficial effect of the PUF was evident from the day of first measurement as the progressive decrease in wound area was observed. On the 2nd day of wounding, the wound area shrinkage in 10% formulation treated group was more when compared to the other test groups. The wound area was decreasing constantly and predominantly in all test treated groups as compared to the negative control group. In the IWM there was decrease in tensile strength of the animals treated with the 10% formulation and was comparable with the standard group. In the histopathological examination, the phases in the wound healing process were observed and it showed that proliferation phase was the predominant stage of action of PUF. The best re-modeling, particularly, re-epithelization were detected with the 10% formulation group On the other hand; faster keratinization characterized with minor intraepithelial cornification was seen in 15% group.
Keywords
Poly Herbal Unani Formulation (PUF), Excision Wound Model (EWM), Incision Wound Model (IWM).- Formulation and Evaluation of Immediate Release Tablets of Topiramate using Sodium Starch Glycolate
Authors
1 Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Hyderabad, Telangana-500001, IN
2 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, IN
3 Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Bhadradri, Kothagudem, Telangana-507115, IN
4 Department of Pharmaceutical Technology, Samskruti College of Pharmacy, Kondapur, Ghatkesar, Medchal, Telangana, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 3024-3028Abstract
The aim of the current study was to develop immediate release tablets (IRT) of topiramate using different concentrations of sodium starch glycolate (SSG) as super disintegrant. Four different formulations of IRT were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 7.5 mg of SSG per tablet gave maximum amount of drug release of 90.76% at the end of 50 mins. Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies revelled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2ºC/75±5% RH) on the best formulation indicated that there were no significant changes in release profile and drug content after a period of one to three month. Among all the formulations, F4 formulation was finally optimized.Keywords
IRT, Topiramate, SSG, Drug Release, FTIR Spectroscopy.References
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