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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, I. S. F. College of Pharmacy, Moga, 142 001,, IN
2 Department of Bio-organic Chemistry, IIIM, Jammu Tawi 180001, IN
3 National Institute of Ayurvedic Pharmaceutical Research, Moti Bagh Road, Patiala, IN
4 Division of Pharmacology, IIIM, Jammu Tawi, 180001, IN
5 Department of Pharmaceutical Chemistry, I. S. F. College of Pharmacy, Moga, 142 001, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 6 (2011), Pagination: 902-904
Abstract
Plants, source of various bioactive compounds have played crucial role in development of several clinically useful anticancer agents' viz., vincristin, vinblastin, camptothecin derivatives and taxol. Combretastatin, a potent anticancer molecule was first isolated from plant. In this continuation a series of combretastatin analogues has been synthesized on the basis of our butterfly model with two wings as aryl groups and connecting carbon chain as the body. In present study we have synthesized combretastatin analogues of different substitutions, showed potent anticancer activity against different cell lines in different fashion according to substitution. Compound 6 showed marked anticancer activity against colo-205 cell lines (colon cancer).
Keywords
Combretastatin, Antitumor, Phenyl Acetic Acid, Tubulin Inhibitor.
