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Tripathi, P. K.
- Synthesis and Characterization of Spirochromanoid Chalcone Derivatives
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Authors
Affiliations
1 Research Lab. of Pure and Applied Chemistry, Maharashtra Mahavidhyalaya, Nilanga (MS), IN
2 Department of Chemistry, Shivneri Mahavidhyalaya, Shirur Anantpal (MS), IN
3 OCT Division, National Chemical Lab., Pune (MS), IN
1 Research Lab. of Pure and Applied Chemistry, Maharashtra Mahavidhyalaya, Nilanga (MS), IN
2 Department of Chemistry, Shivneri Mahavidhyalaya, Shirur Anantpal (MS), IN
3 OCT Division, National Chemical Lab., Pune (MS), IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 8 (2011), Pagination: 1281-1285Abstract
The chalcone derivatives of spirochromanoid frame have been synthesized starting from resorcinol. It is converted in to the spirochomanone protected by N-Boc-4-piperidone. The chalcones of this spirochromanone are synthesized by Claisen Schmidt condensation reacting with 2-chloro benzaldehyde, 2-fluro benzaldehyde, 4-methoxy benzaldehyde, 2,4-dimethoxy benzaldehyde, Benzo-1,3-dioxole-5-carbaldehyde. They are further characterized by their IR, NMR, C13, Depth analysis.Keywords
Spirochromanones, Chalcones, N-Boc-4-Piperidone.
- Novel Floating Insitu gel of Antihyperlipidemic Agent
Abstract Views :218 |
PDF Views:0
Authors
Affiliations
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagar Railway Station, Ulhasnagar, Maharashtra, 421003, IN
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagar Railway Station, Ulhasnagar, Maharashtra, 421003, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 3 (2019), Pagination: 1086-1090Abstract
Simvastatin is an antihypertensive agent used in treatment of hyperlipidemia. It has very short biological half life and it undergoes extensive first pass metabolism. The aim of present work is formulation and characterization of Gastroretentive Insitu gel based system of simvastatin. Different polymers like gellan gum, sodium alginate and HPMC were screened at different concentration to arrive at optimized formulation. Formulations were screened based on invitro gelling time and behavior and drug release. All the batches were evaluated for pH, viscosity, floating lag time and total floating time, water uptake The optimized batch (F8) followed the release as per Korsemeyer-Peppas model and drug release from the formulation can be best explained by the Higuchi model due to highest R-square value among all the models.Keywords
Simvastatin, gastroretentive, insitu Gel.References
- Shashi Kiran Mishra et.al., Formulation and evaluation of oil entrapped gastroretentive floating gel beads of loratadine, Acta Pharm. 58 (2008) 187–197.
- Modasiya, M.K., B.G. Prajapati, V.M. Patel and J.K. Patel, 2010. Sodium alginate based in situ gelling system of famotidine: preparation and in-vivo characterizations. E-Journal of Science and Technology, 5(1): 27-42.
- Kang, B. K.; Lee, J. S.; Chon, S. K.; Jeong, S. Y.; Yuk, S. H.; Khang, G.; Lee, B. H.; Cho, S. H. Development of self microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int. J. Pharm. 2004, 274 (1–2), 65–73.
- Ambike, A. A.; Mahadik, K. R.; Paradkar, A. Spray-Dried Amorphous Solid Dispersions of Simvastatin, a Low Tg Drug; In Vitro and In Vivo Evaluations. Pharm. Res. 2005, 22 (6), 990–998.
- Cheng, H.; Sutton, S. C.; Pipikin, J. D.; Zentner, G. M.; Rogers, J. D.; Schwartz, J. I.; Mitchel, Y. B.; Grasing, K.; Schwartz, M. S.; Amin, R. D.; Liu, L.; Ebel, D. L.; Coulter, A.; Engle, K.; McClelland, G. A.; Lui, C. Y.; Rork, G. S. Evaluation of sustained/controlled-release dosage forms of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor in dogs and humans. Pharm. Res. 1993, 10 (11), 683–1687.
- McClelland, C. A.; Stubbs, R. J.; Fix, J. A.; Pogany, S. A.; Zentner, G.M. Enhancement of 3-hydroxy-3- methylglutaryl-coenzyme A (HMGCoA) reductase inhibitor efficacy through administration of a controlled-porosity osmotic pump dosage form. Pharm. Res. 1991, 8 (7), 873–876.
- Dixit, R. P.; Nagarsenker, M. S. In vitro and in vivo advantage of celecoxib surface solid dispersion and dosage form development. Ind. J. Pharm. Sci. 2007, 69 (3), 370–377.
- Monica Rao, Yogesh Mandage, Kaushik Thanki, Sucheta Bhise, Dissolution improvement of Simvastatin by surface solid dispersion technology, Dissolution technology, May 2010, 27-34.
- Arora S.; Ali J.; Ahuja A.; Khar RK.; Baboota S. Floating Drug Delivery System: A review. AAPS Pharm. Sci. Tech., 2005,6(3)
- Jaimini, M.; Rana A.C.; Tanwar, Y.S. Formulation and evaluation of famotidine floating tablets, Current Druf Delivery., 2007, 4,51-55
- Swati Jagdale, Prasad Kurhe, Bhanudas Kuchekar, Aniruddha Chabukswar, Application of Design of Experiments to Optimizing novel Gastroretentive Drug Delivery of Simvastatin.
- Jyotsana R Madan, Bhushan R Adokar, and Kamal Dua, Development and evaluation of in situ gel of pregabalin, Int J Pharm Investig. 2015 Oct-Dec; 5(4): 226–233.
- Vyas, J.; Ghedia, T.; Gajjar, V. Review on novel in-situ polymeric drug delivery system. Int. J. Pharm. Res. Dev. 2011, 3(5), 53–59.
- Tang, J.; Tung, M.; Zeng, Y. Gelling properties of gellan solutions containing monovalent and divalent cations. J. Food Sci. 1997, 62(4), 688–712.
- Design and Characterization of Self Emulsifying Drug Delivery System of Simvastatin:A Technical Note
Abstract Views :358 |
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Authors
Affiliations
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagaar Railway Station, Ulhasnagar, Maharashtra, IN
2 Bharti Vidyapeet’s College of Pharmacy, Belapur CBD, Navi Mumbai Maharashtra, IN
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagaar Railway Station, Ulhasnagar, Maharashtra, IN
2 Bharti Vidyapeet’s College of Pharmacy, Belapur CBD, Navi Mumbai Maharashtra, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3397-3404Abstract
The objective of the present study was to develop self emulsifying drug delivery system of simvastatin to improve solubility and dissolution rate of simvastatin. Simvastatin in a BCS class II drug (poor solubility, good permeability) and low bioavailability (less than 5%). In present study simvastatin self emulsifying drug delivery system was prepared with triacetin as oil, transcutol as surfactant and propylene glycol as co-surfactant. SMEDDS was characterized for stress study, invitro drug release, globule size, zeta potential, polydispersity index, transmission electron microscopy, exvivo permeation study and pharmacodynamic study. Improvement in antihyperlipidimic potential of SMEDDS as compared to plain drug can be attributed to improvement in solubility and drug dissolution rate of simvastatin.Keywords
Emulsification, Solubility, Particle Size.References
- Warrier D, Zagade A, Shai A, Pawar Y et al. An in-vitro evaluation for the effect of β- Cyclodextrin and PVP-K 30 on drug release pattern of Sertraline Hydrochloride. Int J Pharm and Chem Sci 2012; 1(1):407-13.
- Katteboina S, Chandrasekhar VSR, Balaji PS. Approaches for the development of solid self-emulsifying drug delivery systems and dosage forms. Asian J of Pharm Sci 2009; 4(4):240-53.
- Khoo SM, Humberstone AJ, Porter CJ, Edwards GA et al. Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of Halofantrine. Int J Pharm1998; 167:155-64.
- Kyatanwar AU, Jadhav KR, Kadam VJ. Self micro-emulsifying drug delivery system (SMEDDS): Review. J Pharm Res arch 2010; 3(1):75-83.
- Kawakami K, Yoshikawa T, Moroto Y, Kanakao E et al. Microemulsion formulation for enhanced absorption of poorly soluble Drugs. J Controlled Release 2002; 81:75-82.
- Cortesi R, Espositi E, Maietti A, Menegatti E et al. Formulation study for the antitumor drug Camptothecin: liposomes, micellar solutions and a microemulsion. Int J Pharm 1997; 159:95-103.
- Tolle S, Zuberi T, Lawrence MJ. Physiochemical and solubilisation properties of N, Ndimethyl-N-(3-dodecyloxy propyl) amine oxide: a biodegradable nonionic surfactant. J Pharm Sci 2000; 89:798-806.
- Kang, B. K.; Lee, J. S.; Chon, S. K.; Jeong, S. Y.; Yuk, S. H.; Khang, G.; Lee, B. H.; Cho, S. H. Development of selfmicroemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int. J. Pharm. 2004, 274 (1–2), 65–73.
- Ambike, A. A.; Mahadik, K. R.; Paradkar, A. Spray-Dried Amorphous Solid Dispersions of Simvastatin, a Low Tg Drug; In Vitro and In Vivo Evaluations. Pharm. Res. 2005, 22 (6), 990–998.
- Ghai D and Sinha VR. Nanoemulsions as self-emulsified drug delivery carriers for enhanced permeability of poorly water-soluble selective β-adrenoceptors blocker Talinolol. Nanomed: Nanotech, Biol, Med 2012; 8(5):618-26.
- Versantvoort CHM, Rompelberg CJM, Sips AJAM. Methodologies to study human intestinal absorption.A review. RIVM report 2000:1-55
- Borhade V, Nair H and Hegde D. Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus. AAPS Pharm Sci Tech 2008;9(1):13-21.
- Singh AK, Chaurasiya A, Singh M, Upadhyay SC et al. Exemestane Loaded Self- Microemulsifying Drug Delivery System (SMEDDS): Development and Optimization. AAPS Pharm Sci Tech 2008; 9(2):628-34.
- Shukla JB and Patel SJ. Formulation and Evaluation of Self Micro Emulsifying System of Candesartan cilexetil. Int J Pharm Pharm Sci 2010; 2(4):143-46.
- Singh B, Bandopadhyay S, Kapil R, Singh R et al. Self-Emulsifying Drug Delivery Systems (SEDDS): Formulation Development, Characterization and Applications. Crit Rev Therap Drug Carr Sys 2009; 26(5): 427-21 16. Hong JY, Kim JK, Song YK, Park JS et al. A new self-emulsifying formulation of Itraconazole with improved dissolution and oral absorption. J Controlled Release 2006; 110:332 -38.
- Shukla JB and Patel SJ. Formulation and Evaluation of Self Micro Emulsifying System of Candesartan cilexetil. Int J Pharm Pharm Sci 2010; 2(4):143-46.
- Gershanik T and Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Bio- pharm 2000; 50:179-88.
- Barry R. and Eggenton J. Membrane potentials of epithelial cells in rat small intestine. J Physiol 1972; 227(1): 201-04
- Nutting DF , Tso P . Hypolipidemic effects of intravenous pluronic L-81 in fasted rats treated with Triton WR-1339: possible inhibition of hepatic lipoprotein secretion. Horm Metab Res . 1989 ; 21 : 113 - 115 .
- Schurr PE , Schultz JR , Parkinson TM . Triton-induced hyperlipidemia in rats as an animal model for screening hypolipidemic drugs. Lipids . 1972 ; 7 : 68 - 74 .
- Cheng, H.; Sutton, S. C.; Pipikin, J. D.; Zentner, G. M.; Rogers, J. D.; Schwartz, J. I.; Mitchel, Y. B.; Grasing, K.; Schwartz, M. S.; Amin, R. D.; Liu, L.; Ebel, D. L.; Coulter, A.; Engle, K.; McClelland, G. A.; Lui, C. Y.; Rork, G. S. Evaluation of sustained/controlled-release dosage forms of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor in dogs and humans. Pharm. Res. 1993, 10 (11), 683–1687.
- McClelland, C. A.; Stubbs, R. J.; Fix, J. A.; Pogany, S. A.; Zentner, G.M. Enhancement of 3-hydroxy-3-methylglutaryl-coenzyme A (HMGCoA) reductase inhibitor efficacy through administration of a controlled-porosity osmotic pump dosage form. Pharm. Res. 1991, 8 (7), 873–876.
- Dixit, R. P.; Nagarsenker, M. S. In vitro and in vivo advantage of celecoxib surface solid dispersion and dosage form development. Ind. J. Pharm. Sci. 2007, 69 (3), 370–377.
- Date AA and Nagarsenker MS. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for Cefpodoxime proxetil. Int J Pharm 2007; 329:166-72.