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Pant, P.
- Simple, Rapid and Precise Method for Quality Assessment of Different Parts of Aegle marmelos L. Used in Indian System of Medicine
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Affiliations
1 Central Council for Research in Ayurvedic Sciences, 61-65, Institutional Area, Opp.-D-Block, Janakpuri, New Delhi-110058, IN
2 Arbro Pharmaceuticals (Pvt.) Limited, Kirti Nagar, New Delhi, IN
1 Central Council for Research in Ayurvedic Sciences, 61-65, Institutional Area, Opp.-D-Block, Janakpuri, New Delhi-110058, IN
2 Arbro Pharmaceuticals (Pvt.) Limited, Kirti Nagar, New Delhi, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 5, No 5 (2013), Pagination: 236-243Abstract
Aegle marmelos (L.) Corr. Serr, family Rutaceae is an important medicinal plant and immensely used in the Indian System of Medicine to cure human diseases. Plant parts like ischolar_main, stem bark and fruit have been reported for various medicinal properties such as anti-diabetic, anticancer, anti bacterial, anti fungal, anti pyretic, analgesic, antioxidant, cardio protective, radio protective, anti-diarrheal, anti-dysentery, anti-ulcer, wound healing and many more. A. marmelos is commonly known as a bael in India. Chemo-profiling screening on different parts of A. marmelos plants revealed variations in phytochemicals within different parts of plant. The unique properties of the chromatographic fingerprint were validated by analyzing ischolar_main, stem bark and fruit of A. marmelos. Our results revealed that the chromatographic fingerprint combined with similarity measurement could efficiently identify and distinguish A. marmelos from the other investigated Aegle species. In this paper a new, simple method is proposed in which the TLC pattern of the extracts of ischolar_main, stem bark and fruit of A. marmelos content is used for effective and reliable quality control of the drug. The method can also be used for identification of different A. marmelos species. The proposed method uses cold-extraction then clean-up by solid-phase extraction before chromatographic analysis. The results revealed that the retention factor (Rf) of A. marmelos stem bark, ischolar_main and fruit furnishes a specific TLC chromatogram fingerprint which might be helpful for quality assurance and detection of adulteration of crude extracts. The ischolar_main, stem bark and fruit of A. marmelos L. were also physico-chemically standardized as per WHO specification.Keywords
Aegle marmelos L., Chemo-Profiling, TLC–UV Detection, Physicochemical Analysis.
- Identification and Quantification of Boeravinone-B in Dry Fruit Extract of Boerhaavia diffusa Linn and in its Polyherbal Formulation
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PDF Views:153
Authors
Affiliations
1 Central Council for Research in Ayurvedic Sciences, Janakpuri - 110058, New Delhi, IN
1 Central Council for Research in Ayurvedic Sciences, Janakpuri - 110058, New Delhi, IN
Source
Journal of Natural Remedies, Vol 17, No 3 (2017), Pagination: 88-95Abstract
Objective: To ascertain the authenticity of Boeravinone-B in Boerhaavia diffusa and its poly-herbal dosage form (capsule) by identification and quantification through precise and robust HPLC method. Materials and Methods: The RP-HPLC analysis was accomplished employing phosphate buffer & acetonitrile as mobile phase at a flow rate of 1.5 ml/min and 270 nm as detection wavelength. Results: The content of Boeravinone B in ingredients (hydro-alcoholic extracts of whole plant) and poly-herbal formulation of B. diffusa was estimated as 0.041 % w/w and 0.011 % w/w, respectively with good linearity R2> 0.9997 and retention time 24.413± 0.004 min. Conclusion: The amount of Boeravinone- B present in B.diffusa extracts of raw drug complies with that of reported in literature. Quantification of Boeravinone-B suggested an identification mark for this drug and its different market formulations and may work as quality parameter in standardization. On the basis of percentage of Boeravinone-B the content of B.diffusa in poly-herbal formulation validate the ratio of ingredient in final formulation. This method proved its applicability in quality assessment via quantification of this marker in raw material as well as various phyto-formulations of B.diffusa and widens the acceptability criteria at international level.Keywords
Boerhaavia diffusa Formulation Analysis, Boerhaavia diffusa Whole Plant Extract, Boeravinone-B, Widely Distributed in India, Sri Lanka, Ph.Full Text
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