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Rakha, Pankaj
- Study of Anti-Inflammatory Potential of Ethanolic Fraction of Seeds of Ocimum basilicum Linn
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Authors
Affiliations
1 Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa - 125055, IN
2 Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar (Haryana), IN
1 Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa - 125055, IN
2 Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar (Haryana), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 2 (2009), Pagination: 79-81Abstract
In the present study the ethanolic fraction of seeds of the plant Ocimum basilicum Linn. was taken and its anti-inflammatory potential was evaluated using carrageenan and formalin induced rat paw edema. The effect on chronic phase of inflammation was also studied using cotton pellet granuloma technique. The increase in paw thickness was measured using digital vernier caliper after 1,2,3 and 4 h of injection. Ethanolic fraction of the seeds of the plant at dose of 400 mg/Kg significantly inhibited acute phase of inflammation. The decrease in the weight of granuloma was also found by ethanolic fraction of the seeds at same dose. The study reveals that the ethanolic fraction of seeds of Ocimum basilicum Linn. possesses significant anti-inflammatory activity.Keywords
Anti-Inflammatory, Carrageenan, Formalin, Granuloma.
References
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- Gastroesophageal Reflux Disease: Pathophysiology and Treatments Available
Abstract Views :208 |
PDF Views:1
Authors
Affiliations
1 Rajendra Institute of Technology and Sciences, Sirsa Haryana, IN
2 Chitkara School of Pharmaceutical Sciences, Chitkara University, Barotiwala HP, IN
3 NCRD's Sterling Institute of Pharmacy, Navi Mumbai, IN
1 Rajendra Institute of Technology and Sciences, Sirsa Haryana, IN
2 Chitkara School of Pharmaceutical Sciences, Chitkara University, Barotiwala HP, IN
3 NCRD's Sterling Institute of Pharmacy, Navi Mumbai, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 2 (2010), Pagination: 160-164Abstract
Gastroesophageal reflux disease (GERD) is primarily a motility disorder. Escape of gastric contents into the esophagus occurs as a consequence of an incompetent gastroesophageal barrier. This barrier is weakened in the presence of an abnormally functioning Lower Esophageal Sphincter (LES). This review is focused on the epidemiology, pathophysiology and treatments of gastro-oesophageal reflux disease.Keywords
Reflux, Proton Pump Inhibitors, H2 Receptor Antagonists, Radiofrequency.References
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- Oral Extended Release Drug Delivery System: A Promising Approach
Abstract Views :332 |
PDF Views:2
Authors
Affiliations
1 Lord Shiva College of Pharmacy, Sirsa, Haryana, IN
2 Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research, Asthal Bohr, Rohtak, Haryana, IN
1 Lord Shiva College of Pharmacy, Sirsa, Haryana, IN
2 Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research, Asthal Bohr, Rohtak, Haryana, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 3 (2012), Pagination: 101-106Abstract
Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because ease of administration which lead to better patient compliance. So, oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter half-life and high dosing frequency. Extended release drug delivery system which reduce the dosing frequency of certain drugs by releasing the drug slowly over an extended period of time. There are various physiochemical and biological properties which affect the extended release drug delivery system. This article providing the recent literature regarding development and design of extended release tablets.Keywords
Extended Release, Extended Release Drug Delivery System, Half Life.References
- Aher K B, Bhavar G B, Joshi H P, Chaudhari S R, Recent advances in compression-coated tablets as a controlled drug delivery system, Saudi Pharmaceutical Journal, 2011, 01.
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- Oral Extended Release Drug Delivery System:A Promising Approach
Abstract Views :205 |
PDF Views:0
Authors
Affiliations
1 Lord Shiva College of Pharmacy, Sirsa, Haryana, IN
2 Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research, Asthal Bohr, Rohtak, Haryana, IN
1 Lord Shiva College of Pharmacy, Sirsa, Haryana, IN
2 Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research, Asthal Bohr, Rohtak, Haryana, IN
Source
Asian Journal of Pharmacy and Technology, Vol 2, No 2 (2012), Pagination: 38-43Abstract
Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because ease of administration which lead to better patient compliance. So, oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter half-life and high dosing frequency. Extended release drug delivery system which reduce the dosing frequency of certain drugs by releasing the drug slowly over an extended period of time. There are various physiochemical and biological properties which affect the extended release drug delivery system. This article providing the recent literature regarding development and design of extended release tablets.Keywords
Extended Release, Extended Release Drug Delivery System, Half Life.- Gastroretentive Drug Delivery Systems: A Promising Approach
Abstract Views :177 |
PDF Views:0
Authors
Yashomita Mehta
1,
Sunita Nirban
2,
Sunil Kumar
2,
Kuldeep Malodia
2,
Pankaj Rakha
3,
Manju Nagpal
2
Affiliations
1 Lord Shiva College of Pharmacy, Sirsa, IN
2 Lord Shiva College of Pharmacy, Sirsa, IN
3 Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa, IN
1 Lord Shiva College of Pharmacy, Sirsa, IN
2 Lord Shiva College of Pharmacy, Sirsa, IN
3 Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 1 (2011), Pagination: 1-6Abstract
Controlled release drug delivery system (CRDDS) have been most extensively used to improve therapy of certain drugs, but several physiological difficulties faced with CRDDS is the inability to restrain and remain in the gastric region for several hours which limit the bioavailability of drug. Hence drug delivery systems with prolonged gastric residence time (GRT) are an approach to improve bioavailability of drugs, reduction in dose thereby leading to less side/toxic effects. Many approaches have been utilized in the development of gastric retention drug delivery systems (GRDDS) such as floating system, extended system, high density system, superporus system, bioadhesive system, and magnetic system etc. This review also summarizes the in vitro and in vivo studies to evaluate the performance and application of GRDDS. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.Keywords
Gastric Retention, Effervescent, Floating, Magnetic.- Bioadhesive Polymers as a Platform for Drug Delivery:Possibilities and Future Trends
Abstract Views :233 |
PDF Views:0
Authors
Affiliations
1 Rajendra Institute of Technology and Sciences, Sirsa, IN
2 Guru Jambheshwar University of Science and Technology, Hisar, IN
1 Rajendra Institute of Technology and Sciences, Sirsa, IN
2 Guru Jambheshwar University of Science and Technology, Hisar, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 1-6Abstract
This paper aims to review the developments in the bioadhesive drug delivery systems to provide basic principles to the young scientists, which will be useful to circumvent the difficulties associated with the formulation design. Bioadhesion can be obtained by the building of either non-specific interactions with the mucosal surface, which are driven by the physicochemical properties of the particles and the surfaces, or specific interactions when a ligand attached to the particle is used for the recognition and attachment to a specific site at the mucosal surface. Starting with a review of the oral mucosa, mechanism of drug permeation, and characteristics of the desired polymers, this article then proceeds to cover the theories behind the adhesion of bioadhesive polymers to the mucosal epithelium. The primary goal of bioadhesive controlled drug delivery is to localize a delivery device within the body to enhance the drug absorption process in a site-specific manner. This article reviews desirable properties of bioadhesive polymers and the latest advancement in the field.
Keywords
Bioadhesion, Oral Mucosa, Drug Permeation, Bioadhesive Polymers.- Comparison of Biorelevant and Compendial Dissolution Media and Prediction of In-vivo Plasma Profile of BCS Class II Drug
Abstract Views :216 |
PDF Views:0
Authors
Affiliations
1 Rajendra Institute of Tech. and Sciences, Sirsa, Haryana, IN
2 Rajendra Institute of Tech. and Sciences, Sirsa, Haryana, IN
3 NCRD’s Sterling Institute of Pharmacy, Navi Mumbai, IN
4 Glaxosmithcline Pvt. Ltd., Mumbai,, IN
1 Rajendra Institute of Tech. and Sciences, Sirsa, Haryana, IN
2 Rajendra Institute of Tech. and Sciences, Sirsa, Haryana, IN
3 NCRD’s Sterling Institute of Pharmacy, Navi Mumbai, IN
4 Glaxosmithcline Pvt. Ltd., Mumbai,, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 37-40Abstract
The performance of biorelevant and compendial media was compared to test dissolution of drugs belonging to class II according to Biopharmaceutic Classification Scheme (BCS) and their potential was determined in predicting in-vivo profile. The solubility of Carbamazepine was determined in various media having different pH (water, SGFSP, SIFSP, SGFSPSLS, FaSSIF and FeSSIF), to calculate D/S values in different media. Dissolution of Carbamazepine, a neutral drug was studied using USP apparatus II in water, SGFSP, SIFSP, SGFSPSLS, FaSSIF and FeSSIF. Hixson- Crowell model was applied to determine drug release kinetics. The invivo profile was predicted from invitro dissolution data using modified form of model proposed by Nicolaides in 2001. Dissolution of Carbamazepine from tablet formulation was found to be dependent upon concentration of solubilizing agents. The similarity factor indicated pH independent dissolution of carbamazepine in different dissolution media. The invivo profiles predicted using invitro dissolution of carbamazepine in biorelevant media supported better absorption in the presence of food which matches the literature facts. The Biorelevant Media therefore are better at discriminating invitro release characteristics for forecasting invivo performance of poorly soluble drugs.Keywords
Biorelevant Media, FaSSIF, FeSSIF, BCS.- Anti - Inflammatory Potential of the Seeds of Ocimum basilicum Linn. in Rats
Abstract Views :210 |
PDF Views:0
Authors
Affiliations
1 Guru Jambheshwar University of Science and Technology, Hisar (Haryana), IN
1 Guru Jambheshwar University of Science and Technology, Hisar (Haryana), IN
Source
Asian Journal of Bio Science, Vol 5, No 1 (2010), Pagination: 16-18Abstract
In the present study, the effect of the seeds of the plant Ocimum basilicum Linn. on inflammation induced by histamine and prostaglandins was studied. A total of 60 rats divided in 10 groups were used in this study. The experimental design was approved by IAEC. The increase in paw edema served as the index of inflammation and was measured using digital vernier calipers after injecting various edemogens such as histamine and PGF2α. Petroleum ether fraction (400mg/kg, p.o) and ethanolic fraction (400mg/kg, p.o) of the seeds of Ocimum basilicum Linn. significantly inhibited the paw edema produced by histamine and PGF2-α. These findings reveal that the seeds of the plant Ocimum basilicum Linn. possesses potent anti-inflammatory activity.Keywords
Anti-Inflammatory, Histamine, Prostaglandins.- Anti-Parkinsonian Effect of Aloe vera Juice in Rodents
Abstract Views :618 |
PDF Views:6
Authors
Milind Parle
1,
Pankaj Rakha
1
Affiliations
1 Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar (Haryana), IN
1 Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar (Haryana), IN
Source
Asian Journal of Bio Science, Vol 13, No 1 (2018), Pagination: 39-43Abstract
Parkinson disease is characterized by rigidity, tremors, shuffling gait and bradykinesia.At present, pharmacotherapy of Parkinsonism is limited mostly to symptomatic treatments that do not alter the course of the underlying disease. A number of medicines have been prescribed for treating this disorder particularly Levodopa. In Charak Sanhita, this disorder is named as Kampavata. Enormous numbers of compounds have been fractionated from plant sources for the treatment of Parkinson’s disease. In the present study, an attempt was made to evaluate the anti-parkinsonian effect of Aloe vera juice using different experimental models. The powerful anti-oxidant activity possessed by Aloe vera, when coupled with the observations of the present study such as significant reduction in rigidity, hypokinesia and tremors of animals in different experimental models suggest promising anti-parkinsonian potential of Aloe vera juice.Keywords
Rigidity, Tremors, Bradykinesia, Parkinsonism.References
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- An Apple a Day Keeps Parkinsonism Away
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Authors
Milind Parle
1,
Pankaj Rakha
1
Affiliations
1 Guru Jambheshwar University of Science and Technology, Hisar (Haryana), IN
1 Guru Jambheshwar University of Science and Technology, Hisar (Haryana), IN
Source
International Journal of Medical Sciences, Vol 11, No 1-2 (2018), Pagination: 8-12Abstract
Parkinson’s disease is a progressive neurological disorder characterized by tremors, rigidity, shuffling gait and hypokinesia. Deficiency of Dopamine in substantia nigra pars compacta is the main cause of the disease. Bromocriptine can be used as an alternate to levodopa because this drug is a direct agonist of striatal dopamine receptors. Therefore, in the present study Bromocriptine served as a standard drug. The main phytoconstituents of Apple fruit are vitamin B3, Vitamin B6, flavanoids and phenolic compounds such as polyphenol oxidase. Niacin is also reported to improve cognitive as well as motor function by stimulating the production of neurotransmitters. Therefore, anti-parkinsonian potential of Apple juice was investigated in the present study. Apple juice (0.5 ml and 1ml/100g p.o.) reduced the severity of tremors evoked by oxotremorine (0.5 mg/kg, i. p.). Apple juice diminished rigidity induced by Reserpine and restored the mobility impaired by Reserpine (5mg/ kg, i. p.) in rodents. Apple juice appears to produce its anti-parkinsonian activity mediated via enhanced dopamine and nor-epinephrine synthesis, increased cereberal blood flow through stimulation of NO production, antioxidant activity and neuroprotective action.Keywords
Abnormal Posture, Hypokinesia, Parkinsonism, Apple, Rigidity.References
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