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Mehta, R. S.
- Simultaneous Estimation of Lansoprazole and Domperidone in Combined Dosage Form by RP-HPLC
Authors
1 Ramanbhai Patel College of Pharmacy, Changa, Gujarat, IN
2 Department of Pharmaceutical Analysis, Veerayatan Institute of Pharmacy, Kutch, Gujarat, IN
3 Veeda, Ahmedabad, Gujarat, IN
4 A.R. College of Pharmacy, Vallabh Vidhyanagar, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 2 (2009), Pagination: 210-212Abstract
A RP-HPLC method has developed for simultaneous estimation of lansoprazole and domperidone in combined capsule dosage form. Lansoprazole is a proton pump inhibitor and used in the treatment of duodenal and gastric ulcers and gastroesophageal reflux disease (GERD), a condition in which the acid in the stomach washes back up into the esophagus. Sometimes lansoprazole is used in combination with antibiotics to treat ulcers associated with infection caused by the H. pylori bacteria, gastro-oesophageal reflux disease (GERD), peptic ulcer and Zollinger-Ellison syndrome. Domperidone is indicated for treating symptoms associated with upper gastrointestinal motility disorders caused by chronic and sub acute gastritis. It is a gastrointestinal emptying (delayed) adjunct, a peristaltic stimulant and exhibit antiemetic properties.
The mobile phase used was a combination of Acetonitrile: Methanol (81:19). The detection of the combined dosage form was carried out at 280 nm and a flow rate employed was 1 ml/min. The retention time for lansoprazole and domperidone has found to be 2.8 and 1.57 min respectively. Linearity was obtained in the concentration range of 8-24 μg/ml of lansoprazole and 8-24 μg/ml of domperidone with a correlation coefficient of 0.9977 and 0.9992. Detector consists of photodiode array detector; the reversed phase column used was RP-C18 (2.27μm size, 250 mm´4.6 mm i.d.) at ambient temperature. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed method was successfully applied for simultaneous determination of domperidone and lansoprazole in routine analysis.
Keywords
Simultaneous Estimation, RP-HPLC, Lansoprazole(LAN), Domperidone(DOM).- Quality Assessment of Kushta-e-Gaodanti:A Traditional Unani Medicine
Authors
1 College of Pharmacy, IPS Academy, Indore [M.P], IN
2 School of Pharmacy, Devi Ahilya University, Indore [M.P], IN
3 A R College of Pharmacy, Vallabh Vidyanagar [Gujarat], IN
Source
Asian Journal of Research in Chemistry, Vol 1, No 1 (2008), Pagination: 46-50Abstract
Kushta-e-gaodanti was prepared as per the method mentioned in Unani formulary. The raw materials, intermediates obtained during the preparation of kushta and the final product were characterized using modern analytical techniques like Fourier transform infra-red spectroscopy (FTIR). X-ray powder diffraction (XRPD) and thermo gravimetric analysis (TGA). The study shows that the mineral Gaodanti (calcium sulphate dihydrate) is converted into calcium sulphate hemi hydrate on first calcination in earthen pot sealed with the process gil-e-hikmat. Further on calcination this intermediate is transformed to kushta-e-gaodanti which is orthorhombic α-calcium sulphate anhydride. Kushta-e-gaodanti is a fine powder with particle size 7-8 micrometer, calcium content 29.32%, bulk density 0.928, tapped density 1.268, angle of repose 36.67° and the value of Carr’s index is 47.08. Loss on drying at 110°C and loss on ignition was not more than 0.5 %w/w and 0.05% w/w respectively. Microbial load of the preparation was found negative for the presence of Escherichia coli, Salmonella species and Staphylococcus aureus. Total aerobic count was under acceptance limit. Trace element analysis of bhasma by ICP-OES revealed the presence of some other important metals like arsenic, lead, chromium, cadmium, mercury, tin under acceptable limits at prescribed dose.Keywords
FTIR, Calcination, Unani Traditional Medicine.- Grewia tenax (Frosk.) Fiori – popularization, conservation and utilization of lesser known multipurpose shrub
Authors
1 ICAR-Central Arid zone Research Institute, Regional Research Station, Pali-Marwar 306 401, IN
2 ICAR-Indian Agricultural Research Institute, Hazaribagh 825 405, IN
Source
Current Science, Vol 120, No 10 (2021), Pagination: 1557-1558Abstract
No Abstract.Keywords
No KeywordsReferences
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