Informatics Publishing Limited

K. Natarajan ¹, R. Sathish ², T. Regupathi ³, A. Riyaz ⁴

Affiliations
1 Dept. of Pharmaceutical Biotechnology, Ultra College of Pharmacy, 4/235, Thasildhar nagar, Madurai-625020, IN
2 Dept. of Pharmacology, Ultra College of Pharmacy, Madurai-625020, IN
3 Dept. of Pharmaceutics, Ultra College of Pharmacy, Madurai-625020, IN
4 1Dept. of Pharmaceutical Biotechnology, Ultra College of Pharmacy, 4/235, Thasildhar nagar, Madurai-625020, IN

Abstract

Antibacterial activity of methanol, hexane and petroleum ether extracts of Polyclinum madrasensis was evaluated by cup plate method against various clinical isolates. Two different concentrations (1&4 mg/ml) were analyzed. Methanolic extract of P. madrasensis demonstrated high degree of activity against all tested bacterial isolates in increasing concentrations, whereas hexane extract showed good activity against gram negative pathogens in high concentration and moderate against gram positive pathogens in lower concentration. All strains were resistant to Pet ether extract in both the concentrations when compared to the standard (ciprofloxacin) used. The MIC and MBC for methanolic extract tested in study inferred that the values range between 0.70-0.95 mg/ml and 0.85-1.1 mg/ml respectively. It was concluded from the study that methanolic extract of P. madrasensis exhibits potential antibacterial property.

Keywords

Antimicrobial Activity, Polyclinum Madrasensis, Cup Plate Method, Clinical Isolates

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R. Sathish ¹, K. Natarajan ², S. Selvakumar ³

Affiliations
1 Department of Pharmacology, Ultra College of Pharmacy, Madurai, IN
2 Department of Pharmaceutical Biotechnology, Ultra College of Pharmacy, Madurai, IN
3 Department of Pharmacology, Madurai Medical College, Madurai, IN

Abstract

Swietenia mahagoni (Meliaceae) is an evergreen hard wood timber species widely distributed in India and has ethno medicinal uses in malaria, diabetes, anemia, diarrhoea, fever, and dysentery. In this present study antidiabetic effect of Swietenia mahagoni seeds were evaluated in alloxan induced diabetic mice. Blood and urine Glucose levels, food and water consumptions and histopathological studies were determined. In diabetic mice, Swietenia mahagoni seeds significantly reduced the elevated blood glucose level by 43.92% at 500mg/kg and 42.47% at 250mg/kg compared to vehicle treated diabetic mice, without increase in urine glucose, food and water intake. The experimental data indicated that Swietenia mahagoni demonstrated significant antidiabetic action in alloxan induced diabetic mice and could be a potential orally active drug for diabetes mellitus.

Keywords

Antidiabetic, Indian Mahogany, Alloxan, Diabetic Mice, Swietenia.

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V. Kumar ¹, R. Sathish ²

Affiliations
1 Department of Electronics & Communication Engineering, M.P. Nachimuthu M. Jaganathan Engineering College, Chennimalai, Erode, IN
2 Department of Electrical and Electronics Engineering, M.P. Nachimuthu M. Jaganathan Engineering College, Chennimalai, Erode, IN

Abstract

Models of real system are of fundamental importance in virtually all disciplines. The models are useful for system analysis i.e., or gaining a better understanding of the system. Models make it possible to predict or simulate a system’s behavior. In engineering, models are required for the design of new processes and for the analysis of existing processes. Advanced techniques for the design of controllers, optimizations, supervision, and fault detection are also based on process model. In this paper a simulated comparison of fuzzy logic and neural network control of the truck backer-upper system is presented. The aim of the controller is to back a truck to a loading dock which is a difficult task. It is a nonlinear control problem for which no traditional control system design method exists. We assumed that there were no linguistic rules available, and therefore the controllers were designed from the available numerical data only.
We provided the same desired input-output pairs to both the neural and the fuzzy approaches, and compared the final control performance of both models. It is known that artificial neural networks and fuzzy logics are powerful tools for handling problems of large dimension. Many studies have been reported on the ability of neural networks and fuzzy logics for approximating nonlinear functions. The chores of this paper are to model the truck backer upper control problem using neural networks and fuzzy logic. This paper proposes a comparative study of neural networks (FFN, RBFN and RNN) and fuzzy logic for modeling the truck backer upper control problem. The body angle ∅, x position and the steering angle θ of the truck are used as training data for neural network and fuzzy logic. The results showed the superiority of the neural controller over the fuzzy one, when the later was influenced by the amount of overlapping between its sets and the missing rules from its rule base.

Keywords

Fuzzy Logic, Neural Networks, Nonlinear System Modeling.

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V. Kumar ¹, R. Sathish ²

Affiliations
1 Department of Electronics & Communication Engineering, M.P. Nachimuthu M. Jaganathan Engineering College, Chennimalai, Erode, IN
2 Department of Electrical and Electronics Engineering, M.P. Nachimuthu M. Jaganathan Engineering College, Chennimalai, Erode, IN

Abstract

In this paper a simulated comparison of fuzzy logic and neural network control of the truck backer-upper system is presented. The aim of the controller is to back a truck to a loading dock which is a difficult task. It is a nonlinear control problem for which no traditional control system design method exists. We assumed that there were no linguistic rules available, and therefore the controllers were designed from the available numerical data only.
We provided the same desired input-output pairs to both the neural and the fuzzy approaches, and compared the final control performance of both models. It is known that artificial neural networks and fuzzy logics are powerful tools for handling problems of large dimension. Many studies have been reported on the ability of neural networks and fuzzy logics for approximating nonlinear functions. The tasks of our paper are to model the truck backer upper control problem using different neural networks and fuzzy logic. This paper proposes a comparative study of neural networks (FFN, RBFN and RNN) and fuzzy logic for modeling the truck backer upper control problem. The body angle ∅, x position and the steering angle θ of the truck are used as training data for neural network and fuzzy logic. The results showed the performance of RBFN, better than other neural networks and fuzzy logic with lesser number of iterations, training period and minimum mean square error (MSE).

Keywords

Fuzzy Logic, Neural Networks and Nonlinear System.

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K. Natarajan ¹, S. Ramanathan ¹, R. Sathish ¹, C. Amudhadevi ¹

Affiliations
1 Department of Pharmaceutical Biotechnology, Ultra College of Pharmacy, Madurai, IN

Abstract

Many marine origin organic molecules entered clinical studies for anticancer therapy. Ascidians, a marine invertebrate animal draw attention of the researchers for its versatility as medicine and nutrition. In this study methylene chloride crude extract of Polyclinum madrasensis Sebastian (Ascidaciae) was tested for its in-vitro anticancer property on HeLa cell lines (cervical cancer cell lines) using MTT assay. Results revealed that the extract exhibits cytotoxic effect on the cell lines used (IC 50- 0.23mg/ml). Extract was further elucidated using chemical and spectral analysis (IR, HNMR), in which peptides were found to be the major constituent. As a conclusion, Polyclinum madrasensis is found to be a good source for drug lead component in cancer drug discovery process.

Keywords

Polyclinum madrasensis, PME, Cytotoxicity, HeLa.

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K. Natarajan ¹, S. Tamilarasi ¹, R. Sathish ¹, C. Amudhadevi ¹, T. Regupathi ¹

Affiliations
1 Ultra College of Pharmacy, Madurai, IN

Abstract

Different soil microbes were analyzed for their phosphate solubilizing capacity. The characterization of the microbes which exhibits phosphate solubilisation in preliminary screening reveals that the isolated strains were Pseudomonas aeroginosa, Pseudomonas flurosence, Bacillus subtilis, Bacillus cereus and E. coli. General parameters for determining phosphate solubilisation in PVK broth such as pH changes, estimation of phosphorus release in media and the phosphatase enzyme activity were performed. Investigation results showed high potency of the microbes to solubilize TCP. From the above tested organisms Pseudomonos pocess high efficiency to solubilize TCP followed by Bacillus and E.coli on tested all parameters. Biofertilizer was developed and nursery experiments were conducted with paddy crop. Parameters such as Germination of seed, Color of the crop and Height were analyzed. Biofertilizer treated crop displayed comparatively good results with non treated and chemical fertilizer treated crop. In conclusion Pseudomonas and Bacillus strains showed good phosphate solubilisation and can be utilized in biofertilizers.

Keywords

Phosphate Solubilization, PVK Broth, Pseudomonas, Bacillus.

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R. Sathish ¹, P. Sravan Kumar ¹, K. Natarajan ¹, N. Sridhar ¹

Affiliations
1 Department of Pharmacology, Ultra College of Pharmacy, Madurai, IN

Abstract

The methanolic extract of stem bark of Butea monosperma Lam (MEBM) was studied for the hepatoprotective and antipyretic activities. Carbontetrachloride (1ml/kg, i.p) induced hepatotoxicity and Brewer's yeast (10ml/kg, s.c) induced pyrexia rat models were used. The 10 days treatment of MEBM (200 mg/kg and 400 mg/kg, p.o) showed significant (P<0.01) hepatoprotective effect by dose dependent manner. The MEBM significantly (P<0.01) lowered the elevated levels of serum biochemical parameters such as SGOT, SGPT, ALP, total bilirubin and also significantly (P<0.01) increased total protein levels when compared to toxic control rats. The MEBM at both dose levels (200 mg/kg and 400mg/kg, p.o) produced significant (P<0.01) antipyretic activity throughout the observation period up to 6 h. The phytochemical analysis showed the presence of biologically active constituents such as flavonoids, glycosides and sterols. The flavonoids in the MEBM may be responsible for the significant hepatoprotective and antipyretic activities.

Keywords

Hepatoprotective, Antipyretic, Butea monosperma, Flame of Forest.

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Gurpreet Kaur ¹, R. Sathish ¹

Affiliations
1 Ved Nursing College Panipat, Haryana, IN

Abstract

Background: Suicide is a problem of both public and mental health and is a leading cause of death especially among adolescents. Considering the high rates in adolescents the importance of providing information education and communication helps in promoting social integration and preventing suicide among adolescents.

Aims and Objectives: Study intended to evaluate the effectiveness of information education and communication regarding suicide and its prevention among adolescents in experimental group.

Materials and Method: Evaluative research approach was selected and true experimental research design was adopted to evaluate the effectiveness. Total sample size was 60 and in each group 30 samples were recruited through systematic random sampling technique. Structured knowledge questionnaire was developed and data was collected from the samples through self –reporting questionnaire method. The collected data were analysed by means of descriptive and inferential statistics by using SPSS (IBM Version 20).

Results: The post - test mean score among samples in experimental group was 17.23 (σ = 4.04) and in control group was 9.58 (σ = 3.24). Independent ‘t’ test value was 8.0909 for the degree of freedom 58 and it is statistically significant at P value <0.05.

Conclusion: Evidence obtained from the current study shows improvements in adolescent’s knowledge and awareness about suicide and its prevention. This programme also increased the problem-solving skills and self-efficacy as well as reductions in self-reported suicide vulnerability.

Keywords

Suicide, Knowledge, Adolescents, Suicide Prevention.

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