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Mujoriya, Rajesh
- A Review on Transdermal Drug Delivery System
Authors
1 Sardar Patel College of Technology, (B-Pharmacy), Balaghat, Dist. Balaghat, (M.P.) - 481001, IN
Source
Research Journal of Science and Technology, Vol 3, No 5 (2011), Pagination: 227-231Abstract
Since 1981, transdermal drug delivery systems have been used as safe and effective drug delivery devices. Their potential role in controlled release is being globally exploited by the scientists with high rate of attainment. If a drug has right mix of physical chemistry and pharmacology, transdermal delivery is a remarkable effective route of administration. Due to large advantages of the TDDS, many new researches are going on in the present day to incorporate newer drugs via the system.Keywords
Transdermal, Drug Delivery Devices, Controlled Release.- Formulation Development and Evaluation of Gastro-Retentive Drug (Torsemide) Delivery System for Diuretic Drug
Authors
1 Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 3 (2015), Pagination: 125-130Abstract
Gastro-retentive Drug Delivery System is system which improves the Gastric Residence time and hence improves its bioavailability. In the current study indicates that the optimized gastro-retentive tablet of Torsemide, prepared using Sodium Alginate and HPMC K15M can successfully be employed as an oral controlled release drug delivery system. Tablet was formulated by using different Formulation indicated by F1 to F9 respectively. These formulations were evaluated for the pre compression and post compression parameters. The optimized Formulation was subjected to stability studied at 40°C under humidity conditions (75%) for a period of four week. From the result it was observed that there was no significant change in physiochemical properties as well as in drug release profile even after storage at 40°C for four week. In-vitro drug release study of formulation also done for optimized batch after stability study and found unaffected. High floating ability of the formulation is likely to increase its GI residence time, and eventually, improve the extent of bioavailability. Gastroretentive dosage form of Torsemide will reduce the frequency of administration of drug and helps to minimize dose of drug and side effects associated with the drug.Keywords
Gastro-Retentive Drug Delivery System, Bioavailability, Sodium Alginate, Torsemide, Stability Study, GI Residence Time.- Formulation Development and Evaluation of Mouth Dissolving Tablet of Anti-Allergic Drug (Astemizole)
Authors
1 Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 2 (2015), Pagination: 59-65Abstract
Mouth dissolving tablets are those that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension. In the present study Mouth dissolving tablet of Astemizole was prepared by direct compression method using crosspovidone, Crosscarmellose and Indion 414, as superdisintegrants. Tablet was formulated by using different super disintegrants such as Crosscarmellose, Crosspovidone and Indion 414 in the ratio of 6%, 9% and 12% as represented by F1 to F9 respectively. The tablets prepared were evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and In-vitro dissolution time. All the parameters were found to be within limits. The developed formulation of Astemizole batch F8 (9% Indion 414) showed good palatability and dispersed within 30 seconds as compared to crosscarmellose. In vitro dissolution study of Different Formulation with 9 % crosscarmellose sodium, crosspovidone and Indion 414 showed maximum dissolution rates with 81.32 %, 85.3 % and 95.48 % respectively of the drug released in 4 minutes. The best fitted model for the optimized formulation of F8 batch was found to be higuchi model. Higuchi model show the maximum release of drug having R value 0.996.Keywords
Mouth Dissolving Tablets, Astemizole, Direct Compression Method, Higuchi Model, R Value.- Formulation and Evaluation of Fast Dissolving Tablet of Drug Used In the Treatment of Motion Sickness
Authors
1 Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 3 (2015), Pagination: 181-187Abstract
Fast dissolving tablets are those that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension. In the present study Fast dissolving tablet of Scopolamine Hydrobromide was prepared by direct compression method using Indion 414, Cross Carmellose Sodium and sodium starch glycolate as superdisintegrants. The tablets prepared was evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and in-vitro dissolution time. All the parameters were found to be within limits. Indion 414 as superdisintegrant gives better result as compared to crosscarmellose sodium and Sodium starch glycolate. Tablets disintegrate within 30 sec in mouth having better mouth feel. The developed formulation of Scopolamine Hydrobromide batch F5 (10% Indion 414) showed good palatability and dispersed within 30 seconds as compared to Cross Carmellose Sodium and Sodium starch glycolate.Keywords
Fast Dissolving Tablets, Scopolamine Hydrobromide, Indion 414, Superdisintegrant, Palatability.- Formulation Development and Evaluation of Floating Drug Delivery System for H2-Blocker Drug (Roxatidine Acetate)
Authors
1 Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 3 (2016), Pagination: 190-198Abstract
The present study has been a satisfactory attempt, to formulate and evaluate floating tablet of Roxatidine Acetate with a view of improving bioavailability and giving a controlled release of a drug. Floating tablet of Roxatidine Acetate will reduce the frequency of administration of drug and helps to minimize dose of drug and side effects associated with the drug. Roxatidine Acetate Floating Drug Delivery systems can be prepared by wet granulation method using HPMCK4M: Eudragit-RL100 polymer ratio and PVPK-30 as a binder, Sodium-bi- Carbonate: Citric acid as gas generating agent. The given floating tablet of Roxatidine Acetate was made to prepare with different polymer combination such as Eudragit-RL100: HPMCK4M and varying concentration of HPMCK4M, PVPK30. Comparing the all formulations, Floating drug delivery system formulation of F5 was considered as an ideal formulation which exhibited 99.26% of drug release in 8 hours, and floating lag time of 11seconds with a total floating time of 12 hours.Keywords
Floating Tablet, Bioavailability, Controlled Release, Wet Granulation Method, Floating Lag Time, Total Floating Time.- Formulation Development and Evaluation of Floating Drug Delivery System for Proton Pump Inhibitors (Lansoprazole)
Authors
1 Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 3 (2015), Pagination: 175-184Abstract
The present study has been a satisfactory attempt, to formulate and evaluate floating tablet of Lansoprazole with a view of improving bioavailability and giving a controlled release of a drug. Floating tablet of Lansoprazole will reduce the frequency of administration of drug and helps to minimize dose of drug and side effects associated with the drug. Lansoprazole Floating Drug Delivery systems can be prepared by wet granulation method using HPMCK4M: Eudragit-RL100 polymer ratio and PVPK-30 as a binder, Sodium-bi-Carbonate: Citric acid as gas generating agent. The given floating tablet of Lansoprazole was made to prepare with different polymer combination such as Eudragit-RL100: HPMCK4M and varying concentration of HPMCK4M, PVPK30. Comparing the all formulations, Floating drug delivery system formulation of F5 was considered as an ideal formulation which exhibited 99.26% of drug release in 8 hours, and floating lag time of 11seconds with a total floating time of 12 hours.
Keywords
Floating Tablet, Bioavailability, Controlled Release, Wet Granulation Method, Floating Lag Time, Total Floating Time.- A Review on Study of Microsphere
Authors
1 Sardar Patel College of Technology, {B-Pharmacy}Balaghat, Dist. Balaghat, {M.P.} - 481001, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 2 (2012), Pagination: 80-85Abstract
A plastic compound used in some dermal fillers for the correction of wrinkles that are filled with a substance and released as the shell disintegrates
Controlled release delivery Biodegradable microspheres are used to control drug release rates thereby decreasing toxic side effects, and eliminating the inconvenience of repeated injections.
Microparticulate carrier system can be administered through different routes such as i.v, ocular, i.m,oral,intra arterial.etc. Each route has its own biological significance, limitation AND pharmaceutical feasibility.
Keywords
Dermal Fillers, Biodegradable Microspheres, Controlled Release, Biological Significance.- A Overview on Study of Floating Drug Delivery Systems
Authors
1 Sardar Patel College of Technology, (B-Pharmacy) Balaghat, Dis. Balaghat, (M.P.) – 481001, IN
2 K.I.E.T. School of Pharmacy, Gaziabad, IN