Informatics Publishing Limited

Amit Roy ¹, Ram Kumar Sahu ²

Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur (C.G.), IN
2 Oriental College of Pharmacy, Patel Nagar, Bhopal (M.P.), IN

Abstract

The present study was undertaken to screen anti-inflammatory activity of alcohol and aqueous extracts of leaves from Berberis coriaceae against HRBC membrane stabilization. The prevention of hypotonicity induced HRBC membrane lysis was taken as a measure of the anti-inflammatory activity. Both the extracts showed a biphasic effect on the membrane stabilization. Their activities are comparable to that of the standard drug diclofenac sodium. However their activities decreased with time.

Keywords

Berberis coriaceae, HRBC, Diclofenac Sodium.

Full Text

     

Amit Roy ¹, Ram Kumar Sahu ¹, Pushpa Prasad ¹

Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur-493111 (C.G.), IN

Abstract

The free radical amassed in the body due to oxidative stress, and plays the leading part in the inception of disease. Presently researchers are working on natural antioxidant, because it has minimum toxic effect compared to chemical substances. Pleurotus ostreatus extract were evaluated for phytochemical composition and to assess in vitro antioxidant activities. In the course of preliminary phytochemical analysis, the petroleum ether extract, ethyl acetate extracts and ethanol extracts of P. ostreatus was evaluated to determine the presence of secondary metabolites. Antioxidant activity of the ethanol extract of P. ostreatus was assessed by 1,1-diphenyl-2-picrylhydrazyl (DPPH), Super oxide free radical scavenging assay (SOD) and total polyphenol content. Preliminary phytochemical screening of ethanol extract revealed the presence of phenolic compounds, flavonoids, alkaloids and glycoside, while petroleum ether and ethyl acetate extracts were devoid from these phytoconstituent. The ethanol extract scavenged DPPH radical and superoxide radical with the IC₅₀ being 69.30 μg/ml and 107.05 μg/ml respectively. The ethanol extract of P. ostreatus revealed 83.47 ± 1.53 mg/100 gm of total polyphenol content. The finding endorses that P. ostreatus acquire high antioxidant activities, and it may uses as natural antioxidant for the healing of various diseases.

Keywords

Pleurotus ostreatus, DPPH, Antioxidant, Phytochemical.

Full Text

     

Amit Roy ¹, Dayananda Bhoumik ², Ram Kumar Sahu ¹, Jaya Dwivedi ³

Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur (C.G.), IN
2 Oriental College of Pharmacy, Raisen Road, Bhopal (M.P.), IN
3 Department of Chemistry, Banasthali University, Rajasthan, IN

Abstract

Sesbania grandiflora, family: Fabaceae commonly known as 'sesbania', is widely used as Indian folk medicine. S.grandiflora has the common names of Agati, Corkwood Tree and West Indian Pea. In India it is known as vaka or basna. Traditionally Sesbania grandiflora, is used alone or with other medicinal plants to treat a variety of ailments. The plant's extracts were screened for the presence of phytochemicals and were used to determine their free radical scavenging activity. The extracts showed potent antioxidant activity in the scavenging of DPPH radicals. The potent antioxidant activity of the ethanolic and aqueous extracts of Sesbania grandiflora, may be due to the high phenolic content such as tannins and flavonoids, was proved by estimation of total phenolic content.

Keywords

Sesbania grandiflora, Phytochemical Screening, Phenolic Content, Antioxidant Activity.

Full Text

     

Ram Kumar Sahu ¹, Amit Roy ¹, Saurabh Kothiya ², Anup Kumar Maurya ³, Rajesh Kumar ⁴

Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur (C.G.)-493111, IN
2 Oriental College of Pharmacy, Raisen Road, Bhopal-462021 (M.P.),, IN
3 Shridhar University, Pilani-333031 (Rajasthan), IN
4 Institute of Pharmacy, Kathog-177101 (H.P.), IN

Abstract

The present study was undertaken to evaluate the antipyretic and analgesic activities of the alcohol extract of Cassytha filiformis leaves. The antipyretic activity of C. filiformis (25mg/kg, 50mg/kg and 100mg/kg) was studied in Brewer’s yeast induced pyrexia in rats. The analgesic activity of C. filiformis (25mg/kg, 50mg/kg and 100mg/kg) was studied using Eddy’s hot plate method and heat conduction method in mice. The extract showed significant reduction in the elevated body temperature of rat which was compared with standard Paracetamol. The extract produced significant increase in the reaction time by Eddy”s hot plate method and tail flick method in mice which was compared with standard diclofenac sodium. The alcohol extract of leaves of C. filiformis may have antipyretic and analgesic activities.

Keywords

Cassytha filiformis, Antipyretic, Pyrexia, Analgesic, Paracetamo.

Full Text

     

Amit Roy ¹, Ram Kumar Sahu ¹

Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur (C.G.)-493111, IN

Abstract

The aim of present study was to formulation and development of herbal sunscreen cream containing extracts of plant materials such as Terminalia arjuna, Tinospora cordifolia and Gycyrrhiza glabra. Oil in water (O/W) base cream was prepared from the ethanol extract of T. arjuna, P. corylifolia and G. glabra. The in vitro SPF value of cream was evaluated. The evaluation of cream was done on different parameters like pH, viscosity, spreadibilty, and stability were examined. The prepared cream exhibited highest SPF value 24.35. The herbal cream showed good spreadibilty, good consistency, homogeneity, appearance, pH, ease of removal and no evidence of phase separation. The prepared herbal sunscreen creams was safe to use for skin.

Keywords

Terminalia arjuna, Tinospora cordifolia, Gycyrrhiza glabra, Herbal Sunscreen Cream.

Full Text

     

Ram Kumar Sahu ¹, Amit Roy ¹, Pradeep Kushwah ², Ashmita Sahu ²

Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur (C.G.)-493111, IN
2 Oriental College of Pharmacy, Raisen Road, Bhopal-462021 (M.P.), IN

Abstract

The aim of present study was to formulation and development of face cream comprising extracts of natural products such as Mangifera indica, Azadirachta indica, Coriandrum sativum, Psoralea corylifolia, Mentha arvensis and Daucus carota and almond oil. Different types of formulations oil in water (O/W) base namely F1 to F6 were formulated by incorporating different concentrations Stearic acid and Cetyl alcohol. The evaluation of all prepared base (F1 to F6) were done on different parameters like pH, viscosity, spreadibilty, and stability were examined. The base F3 was found appropriate for the preparation of cream. The extracts were incorporated in base F3 for the preparation of herbal face cream. The herbal face cream showed good spreadibilty, good consistency, homogeneity, appearance, pH, ease of removal and no evidence of phase separation. These herbal face creams were safe to use for skin.

Keywords

Daucus carota, Azadirachta indica, Psoralea corylifolia, Almond Oil, Herbal Cream.

Full Text

     

Ram Kumar Sahu ¹, Amit Roy ¹, Pradeep Kushwah ², Manish Khare ², Rajni Mudotiya ²

Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur (C.G.)-493111, IN
2 Oriental College of Pharmacy, Raisen Road, Bhopal-462021 (M.P.), IN

Abstract

Mostly people use whitening creams to improve their complexion. Melanin plays main role in the skin colour and pigmentation. The tyrosinase catalyzes melanin synthesis, tyrosinase inhibitors are important in cosmetic skinwhitening. The aim of present study was to formulation and development of whitening polyherbal face cream comprising extracts of Curcuma longa rhizomes, Azadirachta indica leaves, Coriandrum sativum seed, Trigonella foenum-graeceum seeds, Mentha arvensis leaves, Cocos nucifera and Prunus amygdalus oil. Different types of formulations oil in water (O/W) base namely F1 to F6 were formulated by incorporating different concentrations of stearic acid and cetyl alcohol. The evaluation of all prepared base (F1 to F6) were done on different parameters like pH, viscosity, spreadibilty, and stability were examined. The base F3 was found appropriate for the preparation of cream. The extracts were incorporated in base F3 for the preparation of polyherbal face cream. The polyherbal face cream showed good spreadibilty, good consistency, homogeneity, appearance, pH, ease of removal and no evidence of phase separation. From the result it can be concluded that the polyherbal face cream providing prevention of skin tanning effect and it is safe to use.

Keywords

Curcuma longa, Azadirachta indica, Trigonella foenum-graeceum, Almond Oil, Polyherbal Cream.

Full Text

     

Ram Kumar Sahu ¹, Harideep Singh ¹, Amit Roy ²

Affiliations
1 Oriental College of Pharmacy, Raisen Road, Bhopal (M.P.), IN
2 Columbia Institute of Pharmacy, Tekari, Near Vidhan Sabha, Mandhar Colony, Raipur (C.G.), IN

Abstract

The plants belonging to Zingiberaceae family are found to be a rich source of substances of phytochemical interest. Curcuma amada is one member of this family which is traditionally used as carminative and stomachic. The antioxidant activity of ethanol and aqueous extract of Curcuma amada rhizomes was studied. The antioxidant activity in vitro was measured by means of the 1, 1-diphenyl-2-picrylhydrazyl (DPPH), Nitric Oxide and Super oxide free radical scavenging assay. Ascorbic acid, a natural antioxidant, was used as a control. The extracts of ethanol and aqueous were strongly scavenged DPPH radical with the IC50 being 265.33 and 217.90 μg/ml respectively. While the extracts of ethanol and aqueous were moderately scavenged superoxide radical with the IC50 values of 526.87 and 440.89 μg/ml and moderately inhibited nitric oxide with the IC50 values of 386 and 510.67 μg/ml. All the parameters were found to dose dependent.

Keywords

Curcuma amada, DPPH, Superoxide, Nitric Oxide.

Full Text

     

Vandna Dewangan ¹, Ram Kumar Sahu ¹, Trilochan Satapathy ¹

Affiliations
1 Department of Pharmacology, Columbia Institute of Pharmacy, Near Vidhansabha, Village Tekari, Raipur, (C.G.) 493111, IN

Abstract

The direct reporting of adverse drug reactions by patients is becoming an increasingly important topic for discussion in the hospital of Pharmacovigilance. Voluntary adverse drug reaction (ADR) reporting is fundamental to medical drug safety surveillance; however, substantial under-reporting exists and is the main limitation of the system. At this time, hospital accepts consumer reports. The World Health Organization estimates that in 2005 and as well as 2019-2021 pneumococcal infections were responsible for the death of 1.6 million human worldwide. Pneumonia, the lungs become filled with fluid and inflamed, leading to breathing difficulties. For some people, breathing problems can become severe enough to require treatment at the hospital with oxygen or even a ventilator. The pneumonia that COVID-19 causes tends to take hold in both lungs. Moxifloxacin, a fluoroquinolone antibiotic, is used for the treatment of respiratory tract, pelvic inflammatory disease, skin, and intra-abdominal infections. Its safety profile is considered favorable in most reviews but has been challenged with respect to rare but potentially fatal toxicities. The most common adverse drug reaction (ADR) constipation is nausea, vomiting, fatigue, alopecia, drowsiness, myelosuppression, skin reactions, anorexia, mucositis, diarrhoea and Medicines that have been particularly implicated in adverse drug reaction-related hospital admissions include anti-platelets, anticoagulants, cytotoxics, immunosuppressant’s, diuretics, anti-diabetics and antibiotics.

Keywords

Moxifloxacin, pneumonia, adverse drug reactions, antibiotic, Fungi, intra-abdominal infections, acute bacterial sinusitis, Fatigue, serious cutaneous reactions, inflammation, adverse event, difficulty breathing.

Full Text