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Tiwari, Ruchi
- Recent Advancements in Periodontal Drug Delivery Systems
Authors
1 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur 208020, (Uttar Pradesh), IN
2 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur 208020, (Uttar Pradesh), IN
3 Gyan Vihar University, Jaipur, Rajasthan, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 2 (2010), Pagination: 125-132Abstract
Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have revolutionised the therapeutic strategies for the management of periodontal disease progression. The rationale for use of antibiotics in periodontal therapy is based on the concept that bacteria are the primary cause of periodontal diseases and thus treatment should be directed towards controlling the bacterial flora.. The effectiveness of mechanical debridement of plaque and repeated topical and systemic administration of antibacterial agents are limited due to the lack of accessibility to periodontopathic organisms in the periodontal pocket. Systemic administration of drugs leads to therapeutic concentrations at the site of infection, but for short periods of time, forcing repeated dosing for longer periods. Local delivery of antimicrobials has been investigated for the possibility of overcoming the limitations of conventional therapy. The use of sustained release formulations to deliver antibacterials to the site of infection (periodontal pocket) has recently gained interest. This review summarises the recent developments in the field of intra-pocket drug delivery systems and identifies areas where further research may lead to a clinically effective intra-pocket delivery system.
- Target Retentive Biodegradable Periodontal Disks for Simultaneous Extended Release of Metronidazole and Doxycycline:Formulation Consideration
Authors
1 Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur, Rajasthan, IN
2 Pranveer Singh Institute of Technology, Kalpi Road Bhauti, Kanpur, (U. P.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 62-66Abstract
Buccoadhesive erodible disks of metronidazole and doxycycline were prepared using different bioadhesive polymers along with excipients like magnesium stearate. The purpose of designing the erodible disk was to obviate the need for removal of exhausted device. The optimized disk containing 3% w/w of magnesium stearate along with hydroxypropylmethylcellulose K4M and sodium carboxy methyl cellulose in the ratio of 1:3 was found to release the drug for a period of over 6.0 h without getting dislodged. Maximum in vitro drug release was found to be 94.78% in 6.0-h study. In situ release characteristics were evaluated using a 'flow-through assembly', which simulated the conditions of the human buccal cavity. The drug concentrations in the in situ samples were found to be above minimum inhibitory concentration (MIC) of the drug. The bioadhesive performance and the surface pH of the disks were satisfactory. Metronidazole and Doxycycline disks were tested against microorganisms commonly found in oro-dental infections namely Staphylococcus aureus, Escherichia coli and Streptococcus mutans. The disk as well as the in situ samples showed inhibition of growth of microorganisms. Thus a stable, extended release periodontal disks containing both metronidazole and doxycycline with satisfactory bioadhesion was developed.