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Rampal, S.
- Safety Assessment of Marbofloxacin Following Repeated Intramuscular Administration in Goats
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1 Dept. of Vety. Pharmacology and Toxicology, GADVASU, Ludhiana, Punjab, IN
2 Dept. of Vety. Physiology and Biochemistry, COVAS, CSKHPKV, Palampur, H.P, IN
1 Dept. of Vety. Pharmacology and Toxicology, GADVASU, Ludhiana, Punjab, IN
2 Dept. of Vety. Physiology and Biochemistry, COVAS, CSKHPKV, Palampur, H.P, IN
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Toxicology International (Formerly Indian Journal of Toxicology), Vol 24, No 3 (2017), Pagination: 288-291Abstract
Marbofloxacin (MB) is an extended spectrum, third generation fluoroquinolone, developed exclusively for the use in veterinary medicine. The safety assessment was done to evaluate the clinical impact of marbofloxacin after repeated intramuscular administration in goats. Safety of drugs is important and changes in serum biochemical and/or hematological markers could provide an early indication of cellular toxicity. The drug was administered at the dose of 2 mg/kg for 5 days by intramuscular route in six healthy, non-lactating Beetal goats, 1.5-2 yrs of age. Haematological (TLC, TEC, Hb, PCV, MCV, MCH and MCHC) and serum biochemical parameters viz. liver function test (LFT) and kidney function test (KFT) (ALT, AST, ALP, GGT, BUN, creatinine, total proteins and albumin) were determined and analyzed to establish the safety profile of marbofloxacin. The hematological and biochemical parameters were found to fluctuate within normal range during treatment period and no significant alterations (p < 0.05) were found in the mean values. The results indicated that intramuscular administration of marbofloxacin in goats at the dose of 2 mg/kg for 5 days seems to be safe.Keywords
Marbofloxacin, Repeated Administration, Safety Assessment, Goats.
References
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- Hemato-Biochemical Alterations Mediated by Carbendazim Exposure and Protective Effect of Quercetin in Male Rats
Abstract Views :252 |
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Authors
Affiliations
1 Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana − 141004, Punjab, IN
2 Department of Veterinary Physiology and Biochemistry, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana − 141004, Punjab, IN
1 Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana − 141004, Punjab, IN
2 Department of Veterinary Physiology and Biochemistry, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana − 141004, Punjab, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 25, No 1 (2018), Pagination: 7-18Abstract
The main objective of study was to investigate the effect of Carbendazim (CBZ) a most popular agriculture fungicide on hemato-biochemical alterations in male rats and possible ameliorative effect of quercetin. Sprague Dawley male rats were administered CBZ @100, 200 and 400 mg/kg body weight, PO and quercetin (25mg/kg body weight, PO) alone and concomitant in corn oil for the period of 28 days. At the end of exposure period, blood was collected and hemato-biochemical parameters were evaluated in blood and plasma samples. Sub-acute exposure of carbendazim resulted in non-significant decrease (p > 0.05) in haemoglobin, PVC and TEC and increase in MCV, MCH and platelets count in CBZ treated groups. Moreover, administration of CBZ significantly increased (p < 0.05) the plasma ALT, AST, ALP, cholesterol and triglyceride while, significantly decreased (p < 0.05) the plasma protein and globulin level was noticed. Non-significant change in calcium, chloride and phosphorous was observed in CBZ alone treated groups. However, quercetin supplementation concomitant in CBZ treated animals prevented and restored the alterations caused by exposure of CBZ. This study concluded that quercetin has ability to ameliorate the toxic effect caused by CBZ on hemato-biochemical biomarkers in living beings.Keywords
Carbendazim, Haemato-Biochemical, Quercetin, Rats.References
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