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Shahi, S.
- Development and Evaluation of Cosmeceutical Nanolipogel
Authors
1 C.U. Shah College of Pharmacy, S. N. D. T. Women’s University, Juhu Campus, Mumbai-400 049, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 1, No 1 (2010), Pagination: 18-24Abstract
Ageing is one of the major problems and the telltale sign of ageing is increased wrinkling of the face along with loss of moisture from the skin, making skin dry and scaly. Exposure of the skin to UV light also causes degenerative effects; this can be minimized by using antioxidants like vitamins A, C or E. Thus the problem of wrinkle and dry skin can be solved using antiwrinkle agent along with vitamins. However, barrier properties of the skin limit their use. Therefore in the present study, BoNT-L-Peptide (INCI name- palmitoyl hexapeptide, 50 ppm solution) and vitamin E acetate was encapsulated into liposome for improving its topical delivery. Liposomes were prepared ethanol injection method and optimized by factorial design approach. Liposomes were characterized for pH, vesicle size, zeta potential, drug content and drug release. Further gels were prepared by using stable liposomal dispersion using carbopol (carbomer) U21, this gel was called as lipogel and were characterized for pH, spreadability, viscosity, drug content and drug release. Stability of liposomal dispersion and lipogel was studied at 25°C/60% RH, 30°C/65% RH&40°C/75% RH as per ICH guidelines. Stable and homogeneous liposomal dispersion and lipogel were developed. The drug content was found in the range of 97 % - 101 %, with the particle size distribution between 159.6( ±0.22) nm to 239.5 (±0.33) nm. Controlled drug release was found to be upto 24 hours at pH 6.8.Keywords
Palmitoyl Hexapeptide, Vitamin E Acetate, Liposomes, Gel.
- Design and Evaluation of Buccoadhesive Microspheres for Smoking Cessation
Authors
1 C.U.Shah College of Pharmacy, S.N.D.T Women’s University, Juhu Campus, Mumbai-400 049, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 90-95Abstract
The present research work was designed with an aim to develop and evaluate buccoadhesive microspheres by cross linking method and determine the suitability of the formulation in nicotine replacement therapy. The developed microspheres were evaluated for various physicochemical parameters like appearance, particle size distribution, DSC studies, angle of repose, drug content, mucoadhesion time, in vitro release behaviour and ex vivo drug permeation through porcine buccal mucosa. The release kinetics was further explored by using Korsmeyer- Peppas equation. Stability studies of optimized batches of microspheres were carried out as per ICH guidelines. The optimized batch was found to have the particle size between 100- 150 μm and angle of repose 28.34±0.2, thus showing good flowability. The DSC thermogram revealed the engulfment of the drug into microspheres. The drug content of all the batches was found to be in the range of 96-105%. The mucoadhesion time was found to be 8.4±0.5 hrs. The in vitro release profile revealed that the drug release was sustained for 8hrs. The n value nearer to 0.5 indicates that the drug followed the Fickian diffusion pattern of release kinetics. Further ex vivo permeation studies of microspheres showed 88.91% drug permeation through the buccal mucosa in 8 hours with good correlation coefficient 0.9980 with the in vitro dissolution studies. Thus the developed microspheres will be a very effective buccal drug delivery system for the treatment of nicotine addiction.