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Sreenivasa, S.
- Design, Synthesis and Pharmacological Evaluation of Novel Bis Acid Amides as Antibacterial and Anti-Inflammatory Agents
Abstract Views :147 |
PDF Views:2
Authors
N. R. Mohan
1,
S. Sreenivasa
2
Affiliations
1 Department of PG Studies in Chemistry, Shridevi PG Centre, Sira Road, Tumkur, Karnataka, IN
2 Department of PG Studies and Research in Chemistry, Tumkur University, Tumkur, Karnataka, IN
1 Department of PG Studies in Chemistry, Shridevi PG Centre, Sira Road, Tumkur, Karnataka, IN
2 Department of PG Studies and Research in Chemistry, Tumkur University, Tumkur, Karnataka, IN
Source
International Journal of Innovative Research and Development, Vol 5, No 11Sp (2016), Pagination: 202-206Abstract
Opening of the five-member ring of dihydrofuran-2,5-dione with amines was used to synthesize a series of amides of4-oxo-4-(substituted) butanoic acid.4-oxo-4-(substituted) butanoic acidamine coupling using 1,1'-carbonyldiimidazole (CDI) was designed to synthesize newbis-acid amide derivatives and pharmacological activities of the compounds were evaluated. Good functional group transformations were observed upon conventional synthesis. Infrared spectroscopy (IR), 1H and 13C nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) analysis were used to establish the structures of the newly synthesized compounds. All the compounds were tested for in-vitro antibacterial and anti-inflammatory activity, some of the compounds were proven to be potent antibacterial and anti-inflammatory agents.
Keywords
Carbon-Nitrogen Bond Formation, Pharmacology, 1,1'-Carbonyldiimidazole, Antimicrobial, Anti-Inflammatory.Full Text
- Green Synthesis of MgO Nanoparticles using Caesalpinia Sappan Seeds and their Application for Direct Conversion of Alcohol to Azide
Abstract Views :89 |
PDF Views:0
Authors
Affiliations
1 Department of Chemistry, Siddaganga Institute of Technology, B.H. Road, Tumakuru-572 103, Karnataka, IN
2 Department of Studies and Research in Chemistry, Tumkur University, Tumakuru-572 103, Karnataka, IN
3 Deputy advisor, National Assessment and Accreditation Council Autonomous Institution affiliated to UGC, MHRD, GOI Banglore 560072, IN
4 Tadimety Aromatics Pvt .Ltd., Hirehally Industrial Area, Tumakuru 572168, IN
1 Department of Chemistry, Siddaganga Institute of Technology, B.H. Road, Tumakuru-572 103, Karnataka, IN
2 Department of Studies and Research in Chemistry, Tumkur University, Tumakuru-572 103, Karnataka, IN
3 Deputy advisor, National Assessment and Accreditation Council Autonomous Institution affiliated to UGC, MHRD, GOI Banglore 560072, IN
4 Tadimety Aromatics Pvt .Ltd., Hirehally Industrial Area, Tumakuru 572168, IN
Source
Journal of Mines, Metals and Fuels, Vol 70, No 8A (2022), Pagination: 70-76Abstract
Azides have been considered as one of the energy rich functional groups as they are prominent precursors for reactive species like nitrenes and nitrenium ions. Also, they were utilized in synthesis of triazoles, triazolines and triazenes. The present work reports an eco- friendly synthesis of MgO NPs by utilizing Caesalpinia Sappan seeds as a novel fuel by solution combustion method. Multiple characterization techniques encompassing FTIR, UV- visible, XRD and SEM were used to study physico-chemical properties of synthesized MgO NPs. A convenient synthesis of amino alcohol via mixed anhydride method was carried out in the first step. Further, amino alkyl azide has been synthesized under mild condition by using the green synthesized MgO nanoparticles as a catalyst along with the addition of 2-azido-1,3-dimethylimidazolinium hexafluorophosphate, a safe, stable and efficient diazo transfer reagent. Structures of newly synthesized compounds were well characterized by HRMS, Proton and C-13 analysis techniques.Keywords
Caesalpinia Sappan, Green Synthesis, MgO NPs, ADMP and Amino Alkyl Azide.
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