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Suryawanshi, S.
- Influence of Coenzyme Q10 on Phenothiazine Induced Extrapyramidal Symptoms in Rats
Authors
1 Department of Pharmacology, H.K.E Society's College of Pharmacy, Sedam Road, Gulbarga - 585105, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 3 (2010), Pagination: 248-251Abstract
Single dose and multiple dose influence of, Coenzyme Q10 in chlorpromazine induced catatonia was studied in adults albino rats of either sex. The study intended to find the role of antioxidants coenzyme Q10 in controlling extrapyramidal side effects. Phenothiazine derivatives produce catatonia as an unwanted side effect when used especially for prolonged periods of time in psychiatric disorders. The catatonia was induced in albino rats using chlorpromazine in the dose of 0.9mg/200g p.o. and the degree of catatonia was recorded.
Coenzyme Q10 was administered first followed by chlorpromazine after 30 minutes p.o in single dose studies. In multiple dose studies Coenzyme Q10 was administered for 8 days followed by the combination of Coenzyme Q10 and chlorpromazine on 9th day as described above and the degree of catatonia was scored. The study reveals that coenzyme Q10 produced statistically significant reduction of extrapyramidal symptoms in both single and multiple dose studies. Thus coenzyme Q10 has beneficial effects in controlling the toxicity symptoms of phenothiazines. Since, coenzyme Q10 is used safely in the form of food supplement it can be recommended in patients who are using phenothiazine derivatives for prolonged periods of time.
Keywords
Chlorpromazine, Catatonia, Coenzyme Q10, Extrapyramidal Symptoms.
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- Insights in Management of Type 2 Diabetes (IMD): A Pan India Survey
Authors
1 Ranbaxy Laboratories Limited, Western Edge - I, Unit No. 201-204, 2nd Floor, Western Express Highway, Borivali (east), Mumbai - 400066, IN
Source
The Indian Practitioner, Vol 67, No 12 (2014), Pagination: 760-765Abstract
Background: Different classes of oral anti-diabetic drugs are available. Management of diabetes is also individualised depending on doctor and patient.
Objective: The objective of the survey was to understand the insights in the management of diabetes in the real world Indian scenario and preference in second choice of oral anti-diabetic drug.
Method: 350 physicians/diabetologist all over India participated in the questionnaire based survey from January 2014 to April 2014. The questions were related to the current prescription patterns of doctors in management of type 2 diabetes and drug preferences and goals in management of type 2 diabetes mellitus.
Results: 91.4% doctors preferred metformin as the first oral agent in pharmacotherapy of type 2 diabetes mellitus. 83.8% preferred sulphonylurea as the second agent in combination with metformin, glimepiride (92.4%) being the preferred sulphonylurea. 25.1% considered addition of second agent when HbA1c > 7%, while 36.7% considered when HbA1c was > 7.5% and 35.8% considered second agent after HbA1c > 8%. 53% doctors directly started dual drug combination treatment when the HbA1c of patients is ≥ 9%.
Conclusion: Metformin is the initial agent in management of diabetes while the second drug in treatment is sulphonylurea with glimepiride being the preferred agent. Significant patient populations do not achieve their HbA1c goals on monotherapy. It is important to avoid clinical inertia in treatment of type 2 diabetes for patients to achieve adequate glycaemic control.
Keywords
Metformin, Sulphonylurea, Glimepiride- Influence of Vitamin-C on Phenothiazine Induced Extrapyramidal Symptoms in Rats
Authors
1 Department of Pharmacology, H.K.E Society's College of Pharmacy, Sedam Road, Gulbarga – 585105, Karnataka, IN