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Gaurav Patel ¹, Sanjay Patel ², Rajendra Mehta ³, Mandev Patel ¹

Affiliations
1 Nootan Pharmacy College, Visnagar - 384 315, Gujarat, IN
2 Shri B.M. Shah College of Pharmaceutical Education & Research, Modasa, Gujarat, IN
3 A. R. College of Pharmacy, Vallabh Vidyanagar - 388 120, Anand, Gujarat, IN

Abstract

A method for simultaneous estimation of Amlodipine besylate and Hydrochlorothiazide in tablet dosage form has been described. The method is based on UV-Spectrophotometric determination of two drugs, using simultaneous equation method. It involves absorbance measurement at 236.17 nm (emax of Amlodipine besylate) and 268.58 nm (emax of Hydrochlorothiazide) in methanol. Linearity was obtained in the range of 6-33 µg/ml for Amlodipine besylate and 3-33 μg/ml for Hydrochlorothiazide. The method allows rapid analysis of binary pharmaceutical formulation with accuracy. Limit of Quantification and Limit of Detection for Amlodipine besylate at 236.17 nm was found to be 2.1 and 0.6, respectively and for Hydrochlorothiazide 0.9 and 0.28, respectively. Limit of Quantification and Limit of Detection for Amlodipine besylate at 268.58 nm was found to be 1.0 and 0.31, respectively and for Hydrochlorothiazide 0.15 and 0.045, respectively. Results of analysis for this method were validated statistically and were found satisfactory.

Keywords

Amlodipine Besylate (AML), Hydrochlorothiazide (HCT), UV-Spectrophotometry.

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Rachit Oza ¹, Nikhil Shah ¹, Sanjay Patel ¹

Affiliations
1 Chemical Engineering Department, Institute of Technology, Nirma University, Ahmedabad-382 481, Gujarat, IN

Abstract

The extraction of nickel from spent catalyst of primary steam reformer from a nearby fertilizer plant using chelation method is reported in this paper. The chelation was carried out using a di-sodium salt of EDTA (ethylene diamine tetra acetic acid) as a chelating agent. The Ni-EDTA complex formed was dechelated using nitric acid as a solvent resulting into the formation of nickel nitrate (NiNO₃) and recovery of EDTA. The recovered EDTA was used for subsequent experiments. The objective was to evaluate nickel removal efficiency of EDTA and reusability of recovered EDTA. The effect of EDTA concentration, time of chelation, catalyst to liquid ratio (S:L) and temperature of chelation were studied in detail. The extraction was up to 95% under the following conditions: 1M concentration of EDTA, solid to liquid ratio 1:10 (g/mL), particle size 1-2 mm, pH 10, 7 hours of chelation time, 400 rpm and 90°C.

Keywords

Spent Catalyst, Chelation, Nickel Recovery.

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