Informatics Publishing Limited

Saroj Kumar Raul ¹, Gopal Krishna Padhy ¹, Soudamini Alekha Charan ¹, Neelima Gurubarik ¹

Affiliations
1 Maharajah's College of Pharmacy, Phoolbaugh, Vizianagaram, Andhra Pradesh, IN

Abstract

The medicinal plants are widely used by the traditional medical practitioners for curing various diseases. Helminthiasis is the most common infection in human affecting a large proportion of world population. Parasitic diseases may cause severe morbidities including lymphatic filariasis and onchocerciasis. Development of resistance to most of the commercially available anti helminthiasis becomes a severe problem worldwide. The present study was under taken to evaluate antihelmenthic activity of ethanol extract of seeds of Cucurbita maxima, Moringa olifera and fruits of Solanum surattense on Indian earthworm pheritima phosthuma. Various concentrations (10, 25, 50 mg/ml) of extracts were tested and results were expressed in terms of time of paralysis and time of death of the worm. Piperazine citrate (10 mg/ml) is used as reference standard and saline water as control.

Keywords

Antihelmenthic Activity, Pheritima Posthuma, Cucurbita maxima, Moringa olifera, Solanum surattense.

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Gurubarik Neelima ¹, Saroj Kumar Raul ¹, Jami Kranthi ¹, Saravakota Sandeep ¹

Affiliations
1 Maharajah’s College of Pharmacy, Vizianagaram, Andhra Pradesh, IN

Abstract

Exposure to sunlight can trigger various biological responses ranging from sunburn, Erythema to skin cancer. Synthetic sunscreen formulation available in the market poses variety of adverse effects. Therefore formulation of herbal sunscreen formulation and evaluation of its sun protection activity is an important aspect in the cosmetic industry.The aim of the present study was to formulate and evaluate the sun protection factor of poly herbal sunscreen cream. In this study five sunscreen creams were formulated using various herbal oils and tested for physiochemical parameters such as color, spreadability, viscosity, limit test for lead, consistency, odour, appearance. Studies like thermal stability, phase separation, liquefaction, centrifugation to check stability and patch test for irritancy were done.The in-vitro SPF of the formulation was determined according to the UV spectrophotometry method of Mansur et.al. The sunscreen cream of formulation (F2) produced high absorbance at 290-320 nm wavelength range and SPF obtained was 1.7208±0.12.From the result obtained in the study we conclude that all the formulation , in particularly formulation F2 significantly contribute to the preparation of photo-protective cosmetic formulation which could prevent the skin from harmful effect of Ultra Violet radiation. These formulations will help in broadening the UV protection ability of the sunscreen along with the greatest advantage of avoiding the adverse and undesired effects of synthetic sunscreen compounds.

Keywords

Sun Protection Factor, Poly-Herbal, UV Spectroscopy, Sunscreen.

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Saroj Kumar Raul ¹, Bukkuru Spandana ¹, Patibandla Sameera ¹, Vegiraju Vikitha ¹

Affiliations
1 Maharajah’s College of Pharmacy, Vizianagaram, Andhra Pradesh, IN

Abstract

A simple, sensitive, rapid, accurate, reproducible and less time consuming visible spectroscopic method has been developed for the determination of Gliclazide in pure and tablet dosage form. The wavelength maxima for gliclazide was found to be 224.05nm. Beer's law was obeyed in the concentration range of 2-20μg/ml. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.15μg/ml and 0.50μg/ml. The percentage recovery of the drug for the proposed method was 99.29% indicating no interference of tablet excipients. The results demonstrate that proposed method is accurate, precise and reproducible while being simple and rapid too for determination of gliclazide in tablet dosage form.

Keywords

Gliclazide, UV Spectroscopy, Method Development, Validation, Estimation.

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Saroj Kumar Raul ¹, Gopal Krishna Padhy ¹, Pramudula Ramya Krishna ¹, Boddu Uma Madhu Priya ¹

Affiliations
1 Maharajah’s College of Pharmacy, Vizianagaram, Andhra Pradesh, IN

Abstract

A simple, accurate, specific and precise UV Spectrophotometric method has been developed for estimation of valsartan in pure and pharmaceutical formulation. The λ_max of valsartan in methanol and water was found to be 248.21 nm. Methanol and water is used as diluent in equal proportion. The drug exhibited the linearity in the concentration range of 2-20μg/ml with correlation coefficient of 0.999. The % recovery of the drug for the proposed was found to be 99.2%. The limit of detection and limit of quantification was found to be 0.15% and 0.45% respectively. No interference was observed in the presence of common pharmaceutical excipient. The method was validated as per ICH guidelines. The developed method was successfully employed for the estimation of valsartan in pharmaceutical dosage form.

Keywords

Valsartan, UV Spectroscopy, Method Development, Validation, Estimation.

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