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Maheshwari, Shishir
- Development and Validation of Simultaneous Equation UV-Spectrophotometric Method for the Estimation of Telmisartan and Amlodipine besylate in Combined Dosage Form
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut-250001
2 HOD, Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut
1 Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut-250001
2 HOD, Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut
Source
Asian Journal of Research in Chemistry, Vol 6, No 8 (2013), Pagination: 765-768Abstract
A simple, sensitive, precise and specific UV spectrophotometric method for simultaneous estimation of Telmisartan and Amlodipine besylate in combine dosage form has been developed. The wavelengths 238 nm and 295 nm were selected for estimation of Amlodipine besylate and Telmisartan respectively, where Methanol was used as solvent. Linearity were observed in the concentration range of 2-25 µg/ml (r2=0.9994) and 2-30 µg/ml (r2=0.9999) for Telmisartan and Amlodipine besylate respectively. These methods were validated according to ICH guidelinesKeywords
Telmisartan, Amlodipine Besylate, Simultaneous Equation Method
References
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- Mahathi, G., 2011, development and validation of Telmisartan and Atorvastatin calcium in combined dosage form by RP-HPLC, International Journal Of Pharmacy and Technology, Vol. 3, Issue 3, pp. 3370-3389.
- Rajeswari, A., 2013. RP-HPLC method development and validation for Simultaneous estimation of Amlodipine besylate and Telmisartan in tablet dosage form, International Journal of Pharmaceutical Research and Analysis, Vol. 3, Issue 1, pp. 13-17.
- Cetin, G. and Sungur, S., 1995. A rapid and sensitive method for the spectrophotometric assay of amlodipine was based on the formation of a colored derived during the reaction of the drug, Scientia Pharmaceutica, Vol. 63, Issue 2, pp. 93-98.
- Mahant, S.S., Shetty, A.S., Gopinath, B., Ahmed, M. And Sridhar, B.K., 2010. A new reverse RP-HPLC method for the simultaneous determination of amlodipine besylate and Telmisartan in combined dosage form, International Journal of Chemical Sciences, Vol. 8, Issue 3, pp. 1895-1904.
- Moen, M.D., 2010. Worked on Telmisartan /amlodipine a singlepill combination of Telmisartan, an angiotensin II receptor antagonist, and amlodipine, a dihydropyridine calcium channel antagonist, WHO, Vol. 10, Issue 6, pp. 401-412.
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- ICH, Q2 (R1) Validation of analytical procedure: Text and methodology, International Conference on Harmonization, Geneva, Switzerland, 2005.
- Development and Validation of Simultaneous Equation UV-Spectrophotometric Method for the Estimation of Metformin HCl and Glimepiride in Combined Dosage Form
Abstract Views :416 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut-250001
2 HOD, Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut
1 Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut-250001
2 HOD, Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut
Source
Asian Journal of Research in Chemistry, Vol 6, No 9 (2013), Pagination: 845-848Abstract
A simple, sensitive, precise and specific UV spectrophotometric method for simultaneous estimation of Metformin HCl and Glimepiride in combined dosage form has been developed. Two wavelengths 233 nm and 228.4 nm were selected for estimation of Metformin HCl and Glimepiride respectively. Acetonitrile was used as solvent for analysis of both the drugs. Linearity was observed in the concentration range of 5-10 μg/ml (r2=0.9992) and 3-18 μg/ml (r2=0.9999) for Metformin HCl and Glimepiride respectively. The method was validated as per ICH guidelines.References
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- Muller G, Hartz D, Punter J, Okonomopulos R, Kramer W; Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor. I. Binding characteristics. Biochim Biophys Acta. 1994; 1191(2):267-77.
- ICH, Q2 (R1) Validation of analytical procedure: Text and methodology, International Conference on Harmonization, Geneva, Switzerland, 2005.