Informatics Publishing Limited

Shiv Kumar Gupta ¹, Babita Kumar ², Pramod Kumar Sharma ³

Affiliations
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), ID
2 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
3 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), IN

Abstract

A simple, rapid and precise isocratic reverse phase High Performance Liquid Chromatographic method has been developed for the determination of Thalidomide capsule. The separation was achieved with 150×4.6mm C₁₈ column using mobile phase as Acetonitrile: Dimethyl Formamide : Water (60:10:30 v/v) at a flow rate of 1.0ml/min with UV detection at 297nm. The retention time of Thalidomide was found to be 2.17min. The linearity range of Thalidomide is 25mg to 200mg with coefficient of correlation 0.9986. The method is found to be accurate, precise and useful in quality control of dosage form.

Keywords

RP–HPLC, Thalidomide, Method Development and Validation

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Shiv Kumar Gupta ¹, Babita Kumar ¹, Pramod Kumar Sharma ²

Affiliations
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
2 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), IN

Abstract

The new simple, sensitive, accurate, precise, rapid and economical method was developed for the estimation of Triamicinolone in solid dosage form. Method is based on the absorbance. Triamcinolone maximum is found at 238 nm in methanol water solvent. The linearity was obtained in the concentration range of 3-9 mcg/ml with coefficient of correlation 0.9998. The value of ruggedness and robustness was found to be 0.2182 and 0.43 respectively. The method is found to be accurate, precise and useful in quality control of dosage form.

Keywords

Triamcinolone, Spectrophotometric and Validation

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Jyoti Dahiya ¹, Anuradha Singh ¹, Shiv Kumar Gupta ¹, Babita Kumar ¹

Affiliations
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN

Abstract

A simple, rapid and precise spectrophotometric method has been developed for determining the enhancement in the aqueous solubility Dextromethorphan. Method is based on the absorbance. Dextromethorphan maximum is found at 278nm with hydrotrope dextromethorphan in double distilled water as solvent. The linearity was obtained in the concentration range of 10-120μg/ml with coefficient of correlation 0.9993.The % RSD in case of intra-day and inter day was found to be 0.8182 and 0.9438 respectively. The value of LOD and LOQ was found to be 3.76 and 1.141 respectively. The method is found to be accurate, precise and useful in quality control of API Drug and also to enhance the aqueous solubility of Dextromethorphan.

Keywords

Dextromethorphan, Hydrotropic Study, Enhancement of Solubility, Method Development and Validation

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Shiv Kumar Gupta ¹, Babita Kumar ², Pramod Kumar Sharma ³

Affiliations
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
2 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.) India, IN
3 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), IN

Abstract

The taste of a drug plays an important role in patient compliance. Ranitidine HCl is a Histamine blocker drug with bitter taste. The drug Ranitidine HCl was treated with a cation exchange resin, which forms complex with the drug and mask the bitterness of Ranitidine HCl. The loading process was optimized for the resin type, pH of loading solution and drug:resin ratio. The resin-drug complex was evaluated for taste by panel method. The rate of dissolution was studied and the drug had showed good release. These findings can be utilized to formulate a non bitter dosage form for Ranitidine HCl with good bioavailability.

Keywords

Ranitidine HCl, Ion Exchange Resin, Taste Masking, Resinates

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Shiv Kumar Gupta ¹, Ramesh C. Poonia ¹, Ritu Vijay ²

Affiliations
1 School of Engineering and Technology, Jaipur National University, Jaipur, IN
2 Department of Computer Science and Electronics, Bansthali University, Rajasthan, IN

Abstract

As the coming generation is going to be the mobile communication technology Generation. If we talk about the communication, at present we are fully equipped with 2G and have started using 3G. But time is not so far when we deal with 4G and it's beyond mobile communication technology. In this paper we have just tried to present the brief overview and limitations of existing systems and how generation next mobile communication technology is going to start new evolution. The G Next revolution, we call it 4G. In this I have discuss the overview, features of 4G, its future vision and scope. This paper will help the new scholars to enhance their knowledge about the different mobile communication existing and G Next systems.

Keywords

FDMA, TDMA, CDMA, GSM, OFDM, WiMax.

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Shiv Kumar Gupta ¹, Ritu Vijay ²

Affiliations
1 School of Engineering and Technology, Jaipur National University, Jaipur, IN
2 Department of Computer Science and Electronics, Banasthali University, Rajasthan, IN

Abstract

Today large organizations are being served by different types of area processing and information systems. It is important to create an integrated repository of what these system contain and do it in order to use them collectively and effectively. The repository contains metadata of source systems effectively. The repository contains metadata of source systems data warehouse and also business data. Metadata, usually called data about data, is an important part. Metadata is supposed to be a helping hand to all co-workers in an organization that work directly or indirectly with the data warehouse. The main purpose of this paper is to determine through feedback from the business end user.

Keywords

Metadata, DSS, DW, ETL, OLAP.

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Shiv Kumar Gupta ¹, Anuradha Singh ¹, Babita Kumar ¹, Bharti Sharma ¹

Affiliations
1 Sanskar College of Pharmacy and Research, Opp. Jindal Pipes Ltd., NH-24, Ghaziabad (U.P.) 201302, IN

Abstract

Underground water contamination is a kind of water pollution or water destruction, in which various contaminants unify together to degrade quality and nature of water. Present scenario most probably support the water contamination by the humans and up to less extent by the natural disasters. The major ions which are responsible to maintain the quality of ground water are carbonate (CO₃ ^2-) and bicarbonate (HCO₃ ^-), Chloride (Cl), Sulphate (SO₄ ^--), Nitrate (NO₃ ^--), Phosphate (PO₄ ^3-), and Fluoride (F^-). The above ions are present in the form of anions. These anions are in general maintain by the cations as Ca⁺⁺,Cu⁺⁺, Mg⁺⁺, Na⁺, and K⁺. Among the above briefed ions Ca⁺⁺ and Mg++ are the ones which are responsible for the hardness of the water. These are found abundantly in the area, where manufacturing of chalk and limestone works take place. Water's hardness is determined by the concentration of multivalent cations in the water. This hard water if consumed by animals or humans lead to the terrific pathological conditions. Three water samples are collected from different locations of Pilkhuwa, District Hapur near to the location of the industry with limestone works, during summer. The ionic concentrations are expressed in mg/L.

Keywords

Ground Water Quality, Total Alkalinity, Total Hardness, Electrical Conductivity, TDS.

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Shiv Kumar Gupta ¹, Anuradha Singh ¹, Babita Kumar ¹, Bharti Sharma ¹

Affiliations
1 Sanskar College of Pharmacy and Research, Opp. Jindal Pipes Ltd., NH-24, Ghaziabad (U.P.) 201302, IN

Abstract

Underground water contamination is a kind of water pollution or water destruction, in which various contaminants unify together to degrade quality and nature of water. Present scenario most probably support the water contamination by the humans and up to less extent by the natural disasters. The major ions which are responsible to maintain the quality of ground water are carbonate (CO₃ ^2-) and bicarbonate (HCO₃ ^-), Chloride (Cl^-), Sulphate (SO₄ ^--), Nitrate (NO₃ ^--), Phosphate (PO₄ ^3-), and Fluoride (F^-). The above ions are present in the form of anions. These anions are in general maintain by the cations as Ca⁺⁺,Cu⁺⁺, Mg⁺⁺, Na⁺, and K⁺.Among the above briefed ions Ca⁺⁺ and Mg⁺⁺ are the ones which are responsible for the hardness of the water. These are found abundantly in the area, where manufacturing of chalk and limestone works take place. Water's hardness is determined by the concentration of multivalent cations in the water. This hard water if consumed by animals or humans lead to the terrific pathological conditions. Three water samples are collected from different locations of Pilkhuwa, District Hapur near to the location of the industry with limestone works, during summer. The ionic concentrations are expressed in mg/L.

Keywords

Ground Water Quality, Total Alkalinity, Total Hardness, Electrical Conductivity, TDS.

Full Text