Informatics Publishing Limited

Shristi Shankar ¹, Rinkee Mohanty ¹, Anurag Satpathy ¹, Rashmita Nayak ¹, Manoj Kumar ¹, Gatha Mohanty ²

Affiliations
1 Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN
2 Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IN

Abstract

Prevalence of systemic diseases by virtue of dental infections, has been widely recognized and accepted by the dental professionals today. In recent times spread of inflammation via neurogenic switching mechanism has found an interest among researchers and reviewers. Neurogenic switching results from the coaction of mast cells and nerves leading to the spread of inflammation from one site of the body to a distant site. Porphyromonas gingivalis, a principle bacterium triggering periodontal disease releases an endotoxin, lipopolysaccharide, which has been found to induce neurogenic switching mechanism, leading to an exacerbation of symptoms of various systemic diseases. Lowering in the microbial count of dental plaque, has shown to recuperate manifestation of various neurological, cardiovascular, respiratory and pregnancy induced conditions. The purpose of this review is to explore the probable link between various systemic diseases and periodontal disease through neurogenic switching mechanism.

Keywords

Neurogenic inflammation, Immunogenic inflammation, Neuropeptides, Substance P, Neurogenic Switching Mechanism, Periodontitis.

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