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Authors
Affiliations
1 Departments of Biotechnology, Sri Padmavati Mahila University, Tirupati, IN
2 Departments of Zoology, Sri Vinkaseswara University, Tirupati, IN
3 Department of Neurology, UT Southwestern Medical center, Dallas, Texas, US
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 16, No 1 (2009), Pagination: 01-04
Abstract
The purpose of this study was to investigate the effect of intraperitoneally administered aluminium acetate on lipid peroxidation and some oxidative stress enzymes in different tissues like brain, liver, kidney, heart, muscle and testis of albino mice. Exposure to sublethal dose (3.5 mg/kg body weight) of aluminium acetate has revealed significant variations in the present study. Under experimental conditions, the levels of XOD increased and it is more in double and multiple dose animals. Significant change was observed in double and multiple dose administered mice. Where as in double dose aluminium acetate administered mice, the consistent elevation has been recorded. Significant increase was observed in multiple dose aluminium acetate administered mice. Such dose dependent elevation has been recorded under aluminium acetate in the present investigation.
Keywords
Different tissues of albino mice, aluminium acetate, detoxification enzymes, lipid peroxidation
