Refine your search
Collections
Co-Authors
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Patil, Swati
- Antibacterial and Anti-Diarrhoel Activities of Flowers of Punica granatum Linn
Abstract Views :272 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmacognosy and Phytochemistry, K M Kundnani College of Pharmacy, Cuffe parade, Mumbai-400 005, IN
2 K M Kundnani College of Pharmacy, Cuffe parade, Mumbai, IN
3 Orchid Research Laboratories Ltd. Chennai, IN
1 Department of Pharmacognosy and Phytochemistry, K M Kundnani College of Pharmacy, Cuffe parade, Mumbai-400 005, IN
2 K M Kundnani College of Pharmacy, Cuffe parade, Mumbai, IN
3 Orchid Research Laboratories Ltd. Chennai, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 2 (2009), Pagination: 87-89Abstract
Different extracts of Punica granatum flowers (Variety: Gulnar) were tested for antibacterial and anti-diarrhoeal activities. All the extracts showed good antibacterial activity which was comparable to that of cold water extract of Punica granatum fruit rind. Cold extracts showed better anti-diarrhoeal activity than soxhlet extracts in castor oil induced diarrhoea in rats as a model. Their anti-diarrhoeal activity was comparable to that of loperamide hydrochloride.Keywords
Punica Granatum, Antibacterial Activity, Anti-Diarrhoeal Activity.
References
- Gislene G F, Nascimento J, Paulo C, Giuliana L. antibacterial activity of plant extracts and phytochemicals on antibiotic resistant bacteria. Brazilian Journal of Microbiology. 2000; 31:247-256.
- Kirtikar K R and Basu B D. Indian Medicinal Plants, M/s Bishen Singh Mahendra Pal Sing, Dehra Dun and M/s Periodical Experts, Delhi, 2nd ed. Vol.II, 1975: pp.1083-1087.
- Nadkarni A K. The Indian Materia Medica, Bombay Popular Prakashan, 3rd ed. vol.2, 1976: pp.1031-1035.
- Balows A. manual of Clinical Microbiology, American Society for Microbiology, Washington DC, 5th ed. 1991: pp. 1105-1116.
- Rawlins EA. Bentley's Textbook of Pharmaceutics, Bailliere Tindall, London, 8th ed.1977: pp. 515-516.
- Hugo W B and Russell A D. Pharmaceutical Microbiology, Blackwell Scientific Publications, 5th ed.1992:pp. 274.
- Subhash CM and Ashok Kumar C K. Studies on antidiarrhoeal activity of Ficus hispida. Leaf extract in rats. Fitoterapia. Volume 73, Issues 7-8, 2002;73(8): 663-667.
- Seth G S. Techniques in Pharmacology, Pharmatech-96 Manual, Department of Pharmacology, Medical college and K. E. M. Hospital, Mumbai, 1996: pp.36-38.
- Gricilda SF and Molly Thomas. Study of anti diarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. J of Ethnopharm.2001;71:73-76.
- Shidore PP, Mujumdar SM, Shrotri DS, Mujumdar AM. Anti-Diarrheal and Anti-Inflammatory Activity of Nutmeg Myristica-Fragrans Extracts. Ind J of Pharm Sci. 1985; 47:188.
- Pillai N R and Lillykutty L. Anti-diarrhoeal potential of Myristica fragrans seed extracts. Ancient Science of Life. 1991; XI (1 and 2): 74-77.
- Screening For Wound Healing Activity of Alcoholic Extract of Ocimum kilimandscharicum Leaves
Abstract Views :274 |
PDF Views:0
Authors
Affiliations
1 K.L.E.S's College of Pharmacy, Ankola - 581314, Karnataka, IN
2 KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
1 K.L.E.S's College of Pharmacy, Ankola - 581314, Karnataka, IN
2 KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 2 (2009), Pagination: 93-96Abstract
Objective: To investigate and rationalize the effects of Ocimum kilimandscharicumleaves(Lamiaceae) for their wound healing activity and probable mechanism underlying its protective effects in albino wistar rats.
Methods: The wound healing activity was evaluated using three different types of wound models viz; the excision, incision and dead space wound model. A supportive study was also made on granuloma tissue to estimate the level of hydroxy proline. The healing tissues obtained on the 11th post wounding day of the incision wound model were processed for histological study.
Results: The animals receiving the alcoholic extract of Ocimum kilimandscharicumleaves has shown to possess significant increase in wound closure rate, skin breaking strength, granuloma breaking strength, hydroxy proline content, granuloma dry weight and decrease in mean scar area.
Conclusion: The prohealing potential of the Ocimum kilimandscharicum leaves extract may probably be as a result of the presence of a mixture of phytoconstituents including flavonoids, steroids, etc. and increased collagen deposition as well as better alignment and maturation.
Keywords
Ocimum Kilimandscharicum, Alcoholic Extract, Wound Healing, Hydroxy Proline, Phytochemicals.References
- Souba WW, Wilmore D: Diet and nutrition in case of the patient with surgery, Trauma and sepsis. In Modern Nutrition in Health and Disease. 9th edition. Edited by: Shils M, Olson J, Shike M, Ross AC. Baltimore, Williams and Wilkins; 1999:1589-1618.
- Ramzi SC, Vinay K and Stanley R .Pathologic Basis of Diseases. WB Saunders Company, Philadelphia. 1994; 5:86.
- Stuart E, Patricia P. Pathophysiology of Healing. 2004; 1st edition: 234
- Charles VM, Rusell RCG, Williams NS. (1995) Short Practice of Surgery, Champan and Hall: London; 9-11.
- Puratchikody A, Nithya Devi C, Nagalakshmi G. Wound healing activity of Cyperus rotundus Linn. Indian J Pharm Sci. 2006; 68(1): 97-101.
- Kweka EJ, Mosha F, Lowassa A, Mahande AM, Kitau J, Matowo J. Ethnobotanical study of some of mosquito repellent plants in north-eastern Tanzania. Malar J. 2008; 7(7): 152.
- Seyoum A, Killeen GF, Kabiru EW, Knols BG, Hassanali A. Field efficacy of thermally expelled or live potted repellent plants against African malaria vectors in western Kenya. Trop Med Int Health. 2003; 8(11): 1005-1011.
- Vaidyaratnam PS. (1994) Varier's Arya Vaidya Sala - Indian Medicinal Plants A Compendium of 500 species, Orient Longman: Chennai; 164-167.
- Lee KH. Studies on the mechanism of action of salicylate. II. Retardation of wound healing by aspirin. J Pharm Sci. 1968; 57: 1042-1043.
- Elrlich HP, Hunt TK. The effects of cortisone and anabolic steroids on the tensile strength of healing wounds. Ann Surg. 1969; 170 (2): 203-206.
- Bonte F, Dumas M, Chaudagne C, Meybeck A. Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis, Planta Med. 1994; 60(2): 133-135.
- Corton S R, Kumar V and Collins T. Robbins Pathologic Basis of Disease, Harcourt Limited, New Delhi (India), Sixth Ed, 2003: 96-111.
- Williams TC and Frohman LA. Potential therapeutic indication for growth hormone releasing hormone in the condition other than growth retardation. Pharmacotherapy. 1986; 6: 311-318.
- Senel O, Cetinkale O, Özbay G, Ahcioglu F and Bulan R. Oxygen free radicals impair wound healing in ischemic rat skin. Ann plast surg. 1997; 39:516-523.
- Rao CM and Ghosh A. Does metronidazole reduce lipid peroxidation in burn injuries. Indian J Pharmacol. 1997; 29: 29-32.
- Manjunath BK, Vidya M, Krishna V, Mankani KL. Wound healing activity of Leucas Hirta. Ind J Pharm Sci. 2006; 5: 380-84.
- Manjunatha KP, Kulkarni GT, Patil GS. Preliminary phytochemical investigation and wound healing activity of the ischolar_mains of Swertia chirata buch. Ham(Gentinaceae). Indian drugs. 2006; 43:535-37.
- Effect of Acacia catechu and Rotula aquatica on the DNA: Implications for Cancer Therapy
Abstract Views :332 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmacognosy and Phytochemistry, Principal K M Kundnani College of Pharmacy, Cuffe Parade, Mumbai-400 005, IN
2 Principal, Singhgad's Institute of Pharmaceutical Sciences, Kusgaon (BK), Lonavala, IN
3 Department of Genetics, BARC, Mumbai, IN
4 Orchid Research Laboratories Ltd. 476, Chennai 600119, IN
1 Department of Pharmacognosy and Phytochemistry, Principal K M Kundnani College of Pharmacy, Cuffe Parade, Mumbai-400 005, IN
2 Principal, Singhgad's Institute of Pharmaceutical Sciences, Kusgaon (BK), Lonavala, IN
3 Department of Genetics, BARC, Mumbai, IN
4 Orchid Research Laboratories Ltd. 476, Chennai 600119, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 1 (2009), Pagination: 31-34Abstract
Ethnobotanical search has revealed the use of water extracts of bark of Acacia catechu and Rotula aquatica in the treatment of cancer. The aqueous extracts of both above mentioned plants were evaluated for antimitotic activity using the meristamatic cells of Allium cepa ischolar_mains. The results showed inhibition of prophase stages in cell division. The A.catechu and R. aquatica treated ischolar_mains of A.cepa were treated with tritiated thymidine. DNA was extracted from these ischolar_main tips. The total DNA was then counted in a scintillation counter. The results were compared with a positive control Methotrexate, a known anticancer drug. Roots treated with Plain water were used as negative control. The total DNA count from the treated ischolar_mains and that from Methotrexate treated ischolar_mains was less than that of Plain water. The extracted DNA was subjected to gel electrophoresis. DNA from ischolar_mains treated with extracts and from Methotrexate treated ischolar_mains showed fragmentation where as that from the Plain water was intact.Keywords
Acacia catechu, Rotula aquatica, Allium cepa, Antimitotic Activity, DNA Isolation.References
- Sharma OP. Chemistry and technology of manufacturing of Katha and Cutch, International book distributors, Meerut, 1984; pp.1-30.
- Wealth of India - Raw materials, Publications and Information Directorate, CSIR, New Delhi, 1972(1); pp. 80.
- Abhang RY, Joglekar PP, Kulkarni P H. Preliminary study on the effect of T. Cordifolia on mitosis. Ancient Science. 1991; 1 and 2:7-8.
- Yang CS, Lee M J, Chen L. Human salivary tea catechin levels and catechin esterase activities: implication in human cancer prevention studies, Cancer Epidemiol Biomarkers Prev. 1999; 8(1): 83-89.
- Mirsky AE, Ris H. Variable and constant components of chromosomes. Nature. 1949 (163); pp. 166 - 8.
- Raven RW, Cancer. Butterworth and Co. Ltd. London, 1957(1); pp. 274-280
- O'Connor L, David CS, Huang S. Apoptosis and Cell Division. Current Opinion in Cell Biology. 2000; 12: 257-263
- Lehninger LA, Nelson A. Principles of Biochemistry, CBS Publishers and Distributors, Delhi, 1993; pp.725 - 818,
- Freifelder D. Molecular Biology, Jones and Bartlett Publishers Inc., Boston, 2nd ed: pp.123-133
- Hazra A, Tripathi SK. Folic acid revisited. Ind J of Pharm. 2001 ;( 33): 322-342.
- Williams GO, Omoh LE, Mitotic Effects of aqueous leaf extract of Cymbopogon citratus in Allium cepa ischolar_main tips. Cytobios. 1996; (87):161-168.
- Chirikjian J. Biotechnology Theory and Techniques, Jones and Bartlett Publishers, London, 1995(I): pp. 51-59.
- Micklos DA, Freyer GA. DNA Science. J Cell Sci. 1974;15(3): 264-267.
- Formulation and Evaluation of Curcuma longa and Azadirachta indica Extracts as Vaginal Contraceptive
Abstract Views :257 |
PDF Views:0
Authors
Affiliations
1 Sinhgad Institute of Pharmaceutical Sciences, Kusgaon (BK), Lonavala Pune-410401, IN
2 Prin. K.M. Kundnani College of Pharmacy, Mumbai-400005, IN
1 Sinhgad Institute of Pharmaceutical Sciences, Kusgaon (BK), Lonavala Pune-410401, IN
2 Prin. K.M. Kundnani College of Pharmacy, Mumbai-400005, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 1 (2012), Pagination: 21-24Abstract
It was noticed that, no safe and reversible chemical agent is known that can adequately control fertility without producing toxic effect. Herbal drugs, the natural alternatives for chemical drugs are defined as the art and science of restoring a sufferer to health by the use of plant remedies. Herbs have long held an important place in the treatment of ailments and herbal medicines are still popular. Herbal medicines are being used by about 80% of the world population primarily in the developing countries for primary health care. They have stood the test of time for their safety, efficacy, cultural acceptability and lesser side effects.In view of above discussion, it is planned to evaluate the extracts of two indigenous plants for spermicidal activity and to develop formulation as vaginal contraceptives.
In the present study the ethanolic extracts of Curcuma longa rhizomes (30μg/ml) and Azadirachta indica leaves (1mg/ml) were alone treated with human semen sample (containing 1million sperm/ml). Both the extract showed dose dependent spermicidal action. The ethanolic extracts of Curcuma longa and Azadirachta indica were alone formulated in two different vaginal gel using Carbapol (1%) and at dose of 10μl evaluated for contact spermicidal activity. Both the vaginal gel was further evaluated for viscosity, spreadability, and mucoadhesive test and stability studies.
The formulation showed significant reduction in sperm motility. Stability studies indicate that formulation is stable at temperature 25°C and 35°C.
It was therefore concluded that the vaginal gel containing Curcuma longa and vaginal gel containing Azadirachta indica extracts may have a wide potential to be used as a vaginal contraceptive agent.
Keywords
Population, Spermicidal, Sperm Count, Vaginal Contraceptives.References
- Mishra R., Singh S., Reversible antifertility effect of aqueous rhizome extract of Curcuma longa in male laboratory mice, Contraception, 79, 2009, 479-487.
- Tara R., Manoj M., Mahadevan R., Curcumin a potential vaginal contraceptive Contraception, 68, 2003, 219-223.
- Khillare B., Shrivastav T., Spermicidal activity of Azadirachta indica (neem) leaf extract, Contraception, 68, 2003, 225-229.
- Mishra R., Sing K., Effect of aqueous Extract of Azadirachta indica on reproductive on reproductive organs in male mice, Indian Journal of Experimental Biology, 43, 2005, 1093-1103.
- Trease, Evans, Aspects of Asian Medicine and its Practice in the West, Pharmacognosy, W.B. Saunders, London, 15, 2002, 470.
- Kour L., Garg R., Gupta G., Topical Gels: A Review, Research Journal of Pharmacy and Technology 3, 2010, 17-24.
- Lee C., In Vitro Spermicidal Tests, Contraception 54, 1996, 131-147.
- Glycine max: The Antioxidant and Anti-Hyperlipidemic Nutraceutical
Abstract Views :455 |
PDF Views:0
Authors
Manasi Nabar
1,
Swati Patil
2
Affiliations
1 Prin. K M Kundnani College of Pharmacy, 23, Jote Joy Bldg., Rambhau Salgaonkar Marg, Cuffe Parade, Mumbai-400005
2 Prin. K M Kundnani College of Pharmacy, 23, Jote Joy Bldg., Rambhau Salgaonkar Marg, Cuffe Parade, Mumbai-400005, IN
1 Prin. K M Kundnani College of Pharmacy, 23, Jote Joy Bldg., Rambhau Salgaonkar Marg, Cuffe Parade, Mumbai-400005
2 Prin. K M Kundnani College of Pharmacy, 23, Jote Joy Bldg., Rambhau Salgaonkar Marg, Cuffe Parade, Mumbai-400005, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 5 (2010), Pagination: 328-331Abstract
The nutraceutical industry has seen a great boom in the recent years as a result of the consumers seeking the convenient "healthful" solution in their diet. Amongst the various candidates of the nutraceutical world the everyday soybean has become a great nutraceutical today. In view of the importance gained by soybeans (Glycine max Family: Leguminosae) studies were carried out on the seeds of soybean. To evaluate its nutraceutical claims, antioxidant and anti-hyperlipidemic evaluations were carried out on the extracts obtained from the seeds of Glycine max. With an increase in the health reports relating free radicals and high lipid levels to an array of disease conditions, there has been a search for a safer solution from the nutraceutical world as a support to the conventional therapy. In the current study, the free radical scavenging activity was carried out using the DPPH method whereas the diet induced hyperlipidemia model in hamsters was used to evaluate the antihyperlipidemic activity. Both the studies yield results that support the current position of soybeans in the nutraceutical world.Keywords
Glycine max, Soybean, Antioxidant, Anti-Hyperlipidemic.References
- Hymowitz T, Soybeans: The Success Story, Advances in New Crops, Timber Press, Oregon, 1990.
- Hymowitz T. On the Domestication of the Soybean. Economic Botany. 1970; 24 (4): 408-421
- Mateos-Aparicio I et al. Soybean, a promising health source. Nutricion Hospitalaria. 2008; 23(4): 305-312
- Brandon DL, Bates AH and Friedman L. Immunoassays for Bowman-Birk and Kunitz Soybean Trypsin Inhibitors in Infant Formula. Journal of Food Science. 2004; 69 (1): 11-15
- Hu J et al. Soyasaponin I and Sapongenol B Have Limited Absorption by Caco-2 Intestinal Cells and Limited Bioavailability in Women. Journal of Nutrition. 2004, 134: 1867-1873
- Rajpal V. Standardization of Botanicals. Eastern Publishers, New Delhi, India, 2005.
- Adams MR et al. Soy protein containing isoflavones reduces the size of atherosclerotic plaques without affecting coronary artery reactivity in adult male monkeys. The Journal of Nutrition. 2005; 135(12): 2852-2856
- Banavalikar MM, Suthar AC and Biyani MK. Pharmacological activities of Genistein, an isoflavone from soy (Glycine max): part II-anti-cholesterol activity, effects on osteoporosis & menopausal symptoms. Indian journal of experimental biology. 2001; 39(6): 520-525
- Dixon RA and Ferreira D. Genistein. Phytochemistry. 2002; 60(3): 205-211
- Suthar AC, Banavalikar MM and Biyani MK, Pharmacological activities of Genistein, an isoflavone from soy (Glycine max): part I--anti-cancer activity. Indian Journal of Experimental Biology. 2001; 39(6): 511-519
- DeFelice SL. Nutraceuticals: Developing, Claiming and Marketing Medical Foods. Marcel Dekker Inc., New York, 1998.
- Patil S, Jolly CI and Narayanan S. Free radical scavenging activity of Acacia catechu and Rotula aquatica: Implications in cancer therapy. Indian Drugs. 2003; 40(6): 328-332
- Vogel HG. Drug Discovery and Evaluation. Springer-Verlag Berlin Heidelberg, Germany, 2002.
- Xiao CW. Health effects of soy proteins and isoflavones in humans. The Journal of Nutrition. 2008; 138(6): 1244S-9S
- Bagchi K and Puri S. Free radicals and antioxidants in health and disease. Eastern Mediterranean Health Journal. 1998; 4(2): 350-360
- Design and Characterization of Albumin-Chitosan Microspheres of Aceclofenac for Sustained Release
Abstract Views :205 |
PDF Views:0
Authors
Affiliations
1 Dept. of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Dept. of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Dept. of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
1 Dept. of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Dept. of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Dept. of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
Source
Research Journal of Science and Technology, Vol 1, No 1 (2009), Pagination: 35-38Abstract
The present study deals with the formulation and characterization of cross linked chitosan/ albumin microspheres containing an NSAID drug Aceclofenac. The microspheres were prepared by suspension cross linking method using gluteraldehyde as a cross linking agent of the polymer matrix. Total eight formulation batches (F1 to F8) were formulated using chitosan/albumin alone and in combinations. The formulations were subjected to various evaluation parameters like % practical yield, entrapment efficiency, particle size distribution, swelling ratio, In vitro release and stability studies. Perfectly spherical cross linked microspheres loaded with aceclofenac were obtained in the size range of 50 - 500 μm. The % practical yield, entrapment efficiency, particle size, swelling ratio were increased with increased concentration of polymer used. The release of aceclofenac was influenced by polymer concentration and size of microspheres. The stability studies of formulation showed 4°C is suitable temperature for storage.Keywords
Cross Linked Microspheres, Controlled Release, Chitosan, Albumin, Aceclofenac.- Formulation and Evaluation of Captopril Fast Dissolving Tablets by WOW Tab and Effervescent Technologies
Abstract Views :197 |
PDF Views:0
Authors
Affiliations
1 Dept. of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Dept. of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Dept. of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
1 Dept. of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Dept. of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Dept. of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
Source
Research Journal of Science and Technology, Vol 1, No 1 (2009), Pagination: 29-32Abstract
Fast dissolving tablets of Captopril were prepared by Wow tab and Effervescent technologies. In this study our aim was to provide the tablet that quickly disintegrates or dissolves upon contact with saliva and also to provide a good mouth feel. The excipients used in both the technologies not only aid fast disintegration of tablets, but also mask the slight bitter taste of drug. All the prepared formulations were evaluated for thickness, hardness, friability, weight variation, drug content, and disintegration time and drug dissolution. Tablets from Wow tab and Effervescent technologies have shown 94 and 96% of the drug release at the end of 10 min respectively. Study has shown that 8:6 ratio of sodium bicarbonate and citric acid in the Captopril fast dissolving tablets gave good soothing and excellent mouth feel. Tablet prepared by Wow tab technology, formulation W5 and W6 using low moldability saccharide (lactose and mannitol) showed rapid disintegration and released about 92 and 96% drug respectively. Study concluded that fast dissolving tablets of Captopril could be prepared successfully by above mentioned methods. Tablets imparted patient benefits and increased consumer satisfaction, despite the different mechanisms involved in these techniques.Keywords
Fast-Dissolving Tablets, Captopril, ACE Inhibitor, Oral Cavity, In vitro Dissolution.- Isolation and Evaluation of Anacardium occidentale Gum as a Binding Agent in Tablet Formulations
Abstract Views :243 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola-581314, IN
2 Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola- 581314, IN
1 Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola-581314, IN
2 Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola- 581314, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 2 (2009), Pagination: 150-157Abstract
Plant products serve as an alternative to synthetic products because of local accessibility, eco-friendly nature and lower prices compared to imported synthetic products. Natural gums and mucilage have been widely explored as pharmaceutical excipients. Mucilage extracted from Anacardium occidentale (Ao) were subjected to toxicity studies for its safety and preformulation studies for its suitability as a binding agent. The present study was undertaken with an objective to find out the binding potentials of a natural gum obtained from plant Anacardium occidentale. Physicochemical characteristics of mucilage, such as solubility, swelling index, loss on drying, and pH were studied and also microbial load was determined. The mucilage was evaluated for its granulating and binding properties in tablets, using Diclofenac as a model drug. Properties of the granules prepared with diclofenac using five different concentrations (2, 4, 6, 8 and 10% w/v) of Ao mucilage and compared with starch (10%, w/v), as standard binder. The prepared granules were evaluated for percentage of fines, average particle size, total porosity, compressibility index and flow properties. The tablets were prepared and evaluated for content uniformity, hardness, friability, disintegration time and in vitro dissolution profiles. The tablets had good physicochemical properties, and the drug release was more than 90% within 90 min. The tablets prepared by using 10% mucilage as binder exhibited more hardness than by using 2, 4 and 8% concentration. At 6% concentration it has given similar disintegration time and dissolution profile in comparison to starch at 10 % w/v. Hence, Ao mucilage at 6% w/v concentrations can be considered as ideal concentrations for preparation of tablets.Keywords
Anacardium Occidentale Mucilage, Binding, Tablets, Diclofenac, Swelling Index.- Curcuma longa and Azadirachta indica:Herbals for Fertility Control
Abstract Views :345 |
PDF Views:0
Authors
Affiliations
1 Sinhgad College of Pharmacy (Poly), Vadgaon (Bk), Pune-411041, IN
2 Principal K. M. Kundnani College of Pharmacy, Mumbai-400005, IN
1 Sinhgad College of Pharmacy (Poly), Vadgaon (Bk), Pune-411041, IN
2 Principal K. M. Kundnani College of Pharmacy, Mumbai-400005, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 3 (2011), Pagination: 124-127Abstract
The increment of population raises many sufferings like lack of food, water, energy and raw material supply. India's population is growing fast, posing a threat to the country's sustained development. Most of the currently used methods of birth control are associated with certain risk and side effects. Herbal medicines are being used by about 80% of the world population primarily in the developing countries for primary health care. They have stood the test of time for their safety, efficacy, cultural acceptability and lesser side effects. In the present investigation the ethanolic extract of Curcuma longa rhizomes and Azadirachta indica leaves alone and in combination were evaluated for reversible antifertility activity in male wistar rats. Administration of extracts alone and in combination for four weeks significantly affects the sperm count, viability, motility and serum testosterone level. Whereas, combination of extracts showed most significant results in both the treatment and recovery groups. Therefore, it may be concluded that the combination of extract posses significant reversible antifertility activity.
Keywords
Population, Antifertility, Sperm Count, Testosterone.- A Study to Assess the Effectiveness of Planned Teaching Programme on Knowledge regarding Electroconvulsive Therapy among Third Year Basic B.Sc. Nursing Students in selected nursing college
Abstract Views :201 |
PDF Views:0
Authors
Affiliations
1 Lecturer and HOD, Sumantai Wasnik Institute of Nursing Nagpur, Indian Youth Welfare Multipurpose Society`s Dist Nagpur, Maharashtra 440023., IN
1 Lecturer and HOD, Sumantai Wasnik Institute of Nursing Nagpur, Indian Youth Welfare Multipurpose Society`s Dist Nagpur, Maharashtra 440023., IN
Source
International Journal of Nursing Education and Research, Vol 10, No 4 (2022), Pagination: 353-360Abstract
A study to assess the effectiveness of planned teaching programme on knowledge regarding electroconvulsive therapy among third year basic B.Sc nursing students in selected nursing college. Objectives: of the study, To assess the level of knowledge regarding Electroconvulsive therapy among third year Basic B.Sc. nursing students, assess the effectiveness of planned teaching on level of knowledge regarding electroconvulsive therapy among third year Basic B.Sc. nursing students and also to determine the association between the level of knowledge regarding Electroconvulsive therapy among third year Basic B.Sc nursing students with their selected demographic variables. This study was based on quantitative approach. Sample: The population was third year B. Sc nursing students in selected nursing college. The sample consisted of 30 students. The inclusion criteria were: (a) Third year basic B.Sc nursing students in selected nursing college. (b) Third year basic BSC nursing students who are willing to participate in the study. (c) Student who knows English. The tool was self-structured knowledge questionnaire. Based on the objectives and the hypothesis the data were analyzed and by using various statistical tests i.e. percentage, mean, chi square and standard deviations‘t’ test. The level of significance set for testing the hypothesis was at 0.05. Results: The findings show that the calculated‘t’ value was 4.29 for knowledge regarding electroconvulsive therapy. The calculated‘t’ value was much higher than the tabulated value. Hence, it was strongly interpreted that the planned teaching regarding electroconvulsive therapy was effective. So, the H1 was accepted.Keywords
Effectiveness, Planned teaching, Knowledge, Electroconvulsive therapy, Nursing students.References
- Rguhs.ac.i n http://www.rguhs.ac.in/cde/onlinecdc/uploads/05_N084_15228.doc
- Ram Kumar Gupta A Text Book of Mental Health Nursing, S. Vikas Andcompany (Medical Publishers).
- Sreevani. A Guide to Mental Health and Psychiatric Nursing: Jaypee Brothers Medical Publishers; 2007.
- Consensus conference. Electroconvulsive therapy 1985.
- Mortality in Depressed Patients Treated with Electroconvulsive therapy and Antidepressants Avery, 1976.
- Science and technology database in WWW.S TOKIZANE, 1996.
- Somatic Therapies in Older Depressed Patients V Krall, 1976.
- Varcarolis, E., Halter, M. J. Foundations of Psychiatric Mental Health Nursing. A clinical approach. 6th ed. Elsevier, Saunders 2011
- Townsend, M.C. Essentials of Psychiatric Mental Health Nursing. 5th edition Philadelphia. F. A. Davis Company 2011
- Cerletti, U., Bini, L. Un Nuova method di shocker pie: “I” electroshock (risotto). Reale Accedemia Medica (Communication all sedate del 28 Maggio 1938-XVI Della Realer Accademia Medica Di Roma). Rome 1938. Fink, M. Convulsive therapy: Theory and practice. Raven Press, New York 1979, 306.
- Townsend, M.C. Essentials of Psychiatric Mental Health Nursing, 5th ed. Philadelphia’s. Davis Company 2011
- Hemphill, K. E., Walter, W. G. The treatment of mental disorders by electrically induced convulsions. J. Ment. Sci. 1941; 87: 256-275 American Psychiatric Association, in: R. D. Weiner, ed. The practice of Electroconvulsive Therapy: recommendation for treatment, training, and privileging: a task force report of the American Psychiatric Association. The American Psychiatric Association VII, Washington, DC. 2001.
- McCall, W. V. Electroconvulsive therapy in the era of modern psychopharmacology. Int. J. Neuropsychop. 2001;
- Enns, M. W., Rises, J. P., Chan, P. Electroconvulsive therapy. [Position Paper 1992-27 R1]. Can. J. Psychiatry. 2010; 55: 1-12. Available from: http://publications. cpaapc.org/media.php?mid=978 (accessed January, 13, 2011)