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Syed Nazimuddin ¹, Maqdoom Farooqui ¹

Affiliations
1 Post Graduate and Research Centre, Dr. Rafiq Zakaria Campus, Maulana Azad College, Rauza Baugh, Aurangabad, 431001, IN

Abstract

Bis (indolyl) methane derivatives were efficiently synthesized by the condensation reaction of various aromatic aldehydes and indole in presence of nickel chloride as a Lewis acid catalyst in PEG-400 as a recyclable green solvent at room temperature. The use of PEG-400 and nickel chloride offers improvements for the synthesis of bis (indoyl) methanes with regard to the yield of products, short reaction times and green aspects utilizing recyclable and non volatile medium and avoiding any volatile and hazardous organic solvent.

Keywords

Bis (Indolyl) Methane, Nicke (II) Chloride, PEG-400.

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Maqdoom Farooqui ¹, Syed Nazimuddin ¹

Affiliations
1 P.G. and Research Centre, Maulana Azad College of Arts, Science and Commerce, Aurangabad, IN

Abstract

Synthesis of 1,3,4-oxadiazole by the reaction of 2-propyl Benzo imidiazol-2-yl carbohydrazide and 1,3, dihydro iso indo-2-yl acetic acid (Phthalyl Amino Acids) in presence of HCl and phosphoryl chloride. All the newly synthesized compounds were screened antibacterial activity which shows moderate to mild activity, and yield of the synthesized compounds were found to be 62-68%.

Keywords

Oxadiazole, Carbohydrazide, Antibacterial Activity, Antifungal Activity, Phthalyl Amino Acids.

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