Informatics Publishing Limited

S. Manokaran ¹, V. S. Saravanan ², T. M. Kulanthavel ², C. T. Kumarrapan ²

Affiliations
1 Dept. of Pharmacognosy, The Erode College of Pharmacy, Veppampalayam, Vallipurathan Palayam (PO), Erode – 638 112, Tamilnadu, IN
2 The Erode College of Pharmacy, Erode, IN

Abstract

The hydro-alcoholic extract of Cucurbita maxima pulp shows the haematological activity against phenyl hydrazine induced anaemic rat. The hydro alcoholic extract of 150 mg/kg and 300 mg/kg are shown significant action against the anaemia, when compared to the 10 mg/kg of phenylhydrazine induced group after 4 weeks of treatment. The parameters determined are haemaglobulin content, RBC, WBC.

Keywords

Haematinic Activity, Cucurbita maxima Pulp, Phenylhydrazine, Haematological Parameters.

Full Text

     

A. Rama Chandra Reddy ¹, K. Roshna ¹, P. Mohanraj ¹, T. M. Kulanthavel ¹, V. S. Saravanan ¹, V. Ganesh ¹

Affiliations
1 Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Veppampalayam, Erode-638112, TN, IN

Abstract

A new simple, sensitive, precise and economical spectrophotometric method of analysis for a bulk drug was developed and validated. The method employed methanol as solvent. The drug was then estimated at 270 nm. The linear regression analysis data for the calibration plots showed good linear relationship with r²=0.999 in the concentration range 0.5-3.0 μg/ml. The mean value of correlation coefficient, slope and intercept were 0.999, 0.0332 and 0.0002 respectively. The method was validated for precision, accuracy and recovery studies. LOD and LOQ for norethisterone was found to be 0.01987 (μg/ml) and 0.06024 (μg/ml) respectively. The method has been successfully applied in the analysis of marketed formulations.

Keywords

Norethisterone, UV Spectrophotometric Analysis.

Full Text