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Roy, Tathagata
- Multi-Hazard Analysis and Design Guidelines: Recommendations for Structure And Infrastructure Systems in The Indian Context
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Authors
Affiliations
1 Multi-Hazard Protective Structures (MHPS) Laboratory, Department of Civil Engineering, Indian Institute of Technology (IIT) Delhi, Hauz Khas, New Delhi 110 016, IN
1 Multi-Hazard Protective Structures (MHPS) Laboratory, Department of Civil Engineering, Indian Institute of Technology (IIT) Delhi, Hauz Khas, New Delhi 110 016, IN
Source
Current Science, Vol 121, No 1 (2021), Pagination: 44-55Abstract
The interdependencies between various risks imposed by natural as well as accidental/man-made hazards demand a holistic design approach to ensure structural safety through multi-hazard engi-neering. In this regard, the present article provides guidelines and recommendations for design of structure and infrastructure systems under multi-hazard scenarios of natural and accidental/man-made hazards, specifically in the Indian context. The need and relevance of multi-hazard analysis and design of structures are elaborated, and key design strategies during design (service) life for normal civil engineering structures as well as critical infrastructure and facilities are recommended for major regions of India experiencing multiple hazards.Keywords
Design Guidelines, Multi-Hazard Analysis, Natural and Man-Made Hazards, Structure and Infrastructure Systems.Full Text
References
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- Protective Effect of Colocasia Esculenta on Tnbs Induced Ulcerative Colitis in Mice
Abstract Views :81 |
PDF Views:0
Authors
Srikanta Chandra
1,
Tathagata Roy
2,
Preeta Bose
2,
Somsubhra Ghosh
3,
Susanta Paul
2,
Victor roychowdhury
2,
Anannya Bose
2,
Ankita Acharya
2
Affiliations
1 Assistant Professor, Jakir Hossain Institute of Pharmacy, Miapur, Murshidabad,742225., IN
2 Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109., IN
3 Assistant Professor, School or pharmacy, Techno India University, Salt Lake, Kolkata-700091, W.B., IN
1 Assistant Professor, Jakir Hossain Institute of Pharmacy, Miapur, Murshidabad,742225., IN
2 Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109., IN
3 Assistant Professor, School or pharmacy, Techno India University, Salt Lake, Kolkata-700091, W.B., IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 1 (2022), Pagination: 385-388Abstract
Objective: Ulcerative colitis (UC) is a recurrent ulceroinflammatory disease that is mainly restricted to colonic mucosa with variable colonic architecture distortion. Different types of drugs are used for management of UC namely Salfasalazine, Balsalazide, Mesalamine etc. However, they are associated with different types of adverse effects such as nausea, vomiting, skin rash, headache. Hence, we narrowed in on Colocasia esculenta and its available in India, Bangladesh, Pakistan. In our present study the anticolitic effects Colocasia esculenta in treatment the TNBS induced model for UC in mice were examined. Methods: Male mice, 7 weeks of age, are selected. They are divided into various categories:Negative control groups treated with normal saline solution ,positive control group treated with TNBS5%, standard group treated with Balsalazide 4mg/kg & TNBS 5% , Test(1) group treated with Colocasia esculenta 100mg/kg, Test(2) group treated with Colocasia esculenta 150 mg/kg, Test(3) group treated with Colocasia esculenta 250 mg/kg then we were performed various parameters such as DAI, Oxidative damage assessment, MPO Assessment. Results: The results have been showed that Colocasia esculenta has significant activity against TNBS (5%) induced colitis when compared to the experimental control, with near normalization of colon architecture. Tissue oxidative stress was reduced with significant improvement in tissue levels of MDA &GSH. Furthermore, significant improvement in levels of myeloperoxidase (MPO) was observed. Conclusion: It is concluded that Colocasia esculenta(250mg/kg) has got potent activity against TNBS (5%) induced ulcerative colitis (UC) due to its anti-inflammatory& antioxidant properties.Keywords
Ulcerative colitis, Anti-inflammatory, Antioxidant, Colocasia esculenta, Myeloperoxidase.
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