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Kaundal, Vishal
- A Concise Review on Synthesis, Anti-inflammatory and Antioxidant Activities of Chalcone
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Authors
Dheeraj Singh
1,
Vishal Kaundal
1,
Neha Aggarwal
1,
Shammy Jindal
2,
Amar Deep Ankalgi
1,
Kamya Goyal
1
Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., IN
2 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P., IN
1 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., IN
2 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P., IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 37 - 44Abstract
Chalcones and their derivatives have been an area of great interest in recent years. Numbers of research publications have been published and chalcones continue to show promising effect for new drug investigations. Chalcone is an advantageous species with medicinal importance as it is consisting of highly reactive ketoethylenic system –CO–CH=CH– which belongs to flavonoids. Chalcones (1, 3-Diphenyl-2-propen-1-one) consists of a three carbon α, β-unsaturated carbonyl system and two or more aromatic rings and acts as precursors for the biosynthesis of flavonoids in plants. However, synthesis in laboratory of broad range of chalcones has also been reported. In chalcone and its derivatives, a highly reactive α, β-unsaturated carbonyl system is the major reason for their pharmacological potencies. Chalcones and their derivatives are known to show a wide range of pharmacological potencies such as anti-inflammatory, antioxidant, antileishmanial, antifungal, anticancer, antibacterial, antiulcer, antiprotozoal, antitumor, antimalarial, antidiabetic, anthelmintic, insecticidal, antigout, antihistaminic, antiviral, antimycobacterial etc. Chalcones can be prepared by Claisen– Schmidt’s condensation, Aldol condensation, Heck’s reaction, Suzuki’s reaction, Ultrasound method of synthesis, Solvent free synthesis of chalcones, One pot synthesis, Sonogashira Isomerization coupling reaction etc. The purpose of the present review is to focus on the various methods of preparation of chalcones and derivatives and their anti-inflammatory and antioxidant potencies.
Keywords
Chalcone, Claisen–Schmidt condensation, Aldol condensation, anti-inflammatory, antioxidant
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Authors
Vishal Kaundal
1,
Dheeraj Singh
1,
Vipasha
2,
Arti Devi
3,
Shammy Jindal
4,
Amar Deep Ankalgi
5,
Kamya Goyal
5
Affiliations
1 1Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India, IN
2 Department of Pharmacology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India., IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India, IN
4 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P., India, IN
5 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India., IN
1 1Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India, IN
2 Department of Pharmacology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India., IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India, IN
4 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P., India, IN
5 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India., IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 12, No 1 (2022), Pagination: 21-28Abstract
Chalcones and their derivatives have been an area of great interest for several researchers in recent years. Several number of research publications have been published and chalcones continue to show promising effect for novel drug investigations. Chalcone is an advantaged moiety with therapeutic importance as it comprises of receptive ketoethylenic moiety – CO–CH=CH– having a place with flavonoids. Chalcones (1, 3-Diphenyl-prop-2-en-1-one) consists of a three carbon α, β-unsaturated carbonyl system and two or more aromatic rings and acts as precursors for the biosynthesis of flavonoids in plants. The presence of a highly reactive α, β-unsaturated carbonyl system in chalcone and its derivatives is the justification for its pharmacological potencies. However, synthesis in laboratory of broad range of chalcones has also been reported. Chalcones show a wide range of pharmacological impacts like anthelmintic, antileishmanial, antifungal, antimalarial, antioxidant, antiviral, antibacterial, antiulcer, antimycobacterial, insecticidal, antigout, antihistaminic, antiprotozoal, insecticidal, anticancer, antidiabetic, anti-inflammatory, analgesic etc. Chalcones can be synthesized through Claisen–Schmidt's condensation, Heck's reaction, Aldol condensation reaction, Suzuki's reaction, from cinnamic acid, Sonogashira Isomerization Coupling reaction, Microwave assisted synthesis etc. The purpose of the present review is to centralize the various and widely employed methods of synthesis of chalcone and their various derivatives and their antimicrobial and antioxidant activities.Keywords
Chalcones, Antimicrobial activity, Antioxidant activity, Claisen–Schmidt condensation, Microwave assisted synthesis.References
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