A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Sirisha, Y.
- Formulation and Evaluation of Bilayered Buccal Adhesive Tablets of Carvedilol
Authors
1 Bapatla College of Pharmacy, Bapatla Educational Society, Bapatla, Guntur District, Andhra Pradesh-522101, IN
Source
Research Journal of Science and Technology, Vol 3, No 6 (2011), Pagination: 335-339Abstract
Carvedilol is a non selective α and β receptor blocker which undergoes extensive hepatic first pass metabolism by liver and has poor oral bioavailability of 25% - 30%. In the present investigation Carvedilol was formulated as a bilayered buccal adhesive tablets in order to avoid the firstpass effect and decrease the drug loss using different polymers and excipients. Twelve formulations were made using different concentrations (17%w/w, 35%w/w, 53%w/w) of Carbopol934P, HPMC (3500-6000cps), HPC and Guar gum. The formulations were tested for %weight variation, hardness, Friability, %Drug content, in-vitro drug release, surface pH, Swelling index and Mucoadhesive strength. Mucoadhesive strength was determined by the modified balance method in grams and was found to be between 27.75±0.234gm to 75.94±0.146gm and Surface pH was found to be 7. In-vitro release studies revealed that as polymer concentration increases from 17% to 53%w/w, rate of drug release was retarded and the data was fitted into pharmacokinetic models. Among all other formulations, formulations (F4,F8 and F11) containing 17%w/w HPMC, 35%w/wHPC and 35%w/w Guar gum were found to be best as the release was retarded upto 8.5 hours and they have good mucoadhesive strength and they follow zero order with non-fickian diffusion mechanism.Keywords
Bilayered Buccal Tablets, Carvedilol, Carbopol934P, HPMC, HPC, Guar Gum.- Enhancement of Dissolution Rate Studies on Solid Dispersion of Aceclofenac
Authors
1 Department of Pharmaceutics, Padmavathi College of Pharmacy, Dharmapuri (DT), IN
2 Padmavathi College of Pharmacy, Dharmapuri (DT), Tamil Nadu, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 107-110Abstract
Aceclofenac is a Non- Steroidal Anti Inflammatory drug indicated for the relief of pain and inflammation, associated with rheumatoid arthritis, osteo arthritis, ankylosing, spondylitis. The percentage of dissolution rate of drug released from pure Aceclofenac was obtained 26.48% in 180min. The aim of the study was to enhance the dissolution rate on solid dispersion of Aceclofenac by using PEG6000 as carrier in three different ratios such as ACF:PEG6000-1:1, 1:2 and 1:4 by fusion method or melting method. The percentage of drug release of Aceclofenac from solid dispersions ACF:PEG6000-1:1,1:2 and 1:4 was 59.65%,84.75%,98.34% respectively in 180min. Aceclofenac from solid dispersions due to enhancing effect of PEG6000.