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Susilawati, Yasmiwar
- Hypoglycemic Activity of Ethyl Acetate Fraction of Mengkudu Fruit (Morinda citrifolia L.) in Mice Induced Alloxan
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Authors
Affiliations
1 Department of Pharmacology and Pharmacy Clinic, Padjadjaran University, Jalan Raya Bandung-Sumedang KM 21, Jatinangor, West Java, ID
2 Department of Pharmaceutical Biology, Padjadjaran University, Jalan Raya Bandung-Sumedang KM 21, Jatinangor, West Java, ID
1 Department of Pharmacology and Pharmacy Clinic, Padjadjaran University, Jalan Raya Bandung-Sumedang KM 21, Jatinangor, West Java, ID
2 Department of Pharmaceutical Biology, Padjadjaran University, Jalan Raya Bandung-Sumedang KM 21, Jatinangor, West Java, ID
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 197-201Abstract
Complementary medicine for diabetes mellitus using medicinal plants is the solution chosen as an alternative treatment. Mengkudu fruit (Morinda citrifolia L.) is empirically used by the community for the treatment of diabetes mellitus. To study the hypoglycemic activity of subfraction mengkudu fruit in mice induced alloxan. The test results on subfraction of ethyl acetate fraction (dose 150 mg/kgBW) induced alloxan (dose 175 mg/kgBW) showed that there was a decrease in blood glucose levels including Mc-IIb (33.94%), Mc-IIc (32.21%), Mc-IIa (29.58%), Mc-IId (18.16%) and Mc-IIe (8.09%) were significantly different compared to the negative control (p<0.05). Subfraction Mc-IIb shows that the most active hypoglycemic activity may be due to some secondary metabolites such as flavonoids, saponins, alkaloids, and polyphenols as antidiabetic bioactive principles. These research showed that Mc-IIb subfraction indicates the highest hypoglycemic activity. However, the research for the active hypoglycemic compound of Mc-IIb subfraction needs to be explored further.Keywords
Morinda citrifolia, Ethyl Acetate Fraction, Subfraction, Hypoglycemic, Alloxan.
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- Differentiation Roselle (Hibiscus Sabdariffa L.) Extract from Various Plants with FTIR-chemometric Method
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Authors
Affiliations
1 Department of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Jalan Raya Bandung- Sumedang KM 21, Jatinangor, West Java,, ID
2 Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Padjadjaran University, Jalan Raya Bandung- Sumedang KM 21, Jatinangor, West Java,, ID
1 Department of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Jalan Raya Bandung- Sumedang KM 21, Jatinangor, West Java,, ID
2 Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Padjadjaran University, Jalan Raya Bandung- Sumedang KM 21, Jatinangor, West Java,, ID
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 878-884Abstract
Background: Roselle prospectively can be developed as herbal medicine raw materials. The high amount availability of roselle raw material sources leads to diverse roselle extract quality therefore a particular method is required to differentiate roselle extracts. FTIR-chemometric is a method that is used to evaluate plant quality by processing chemical data information through mathematically and statistically calculations. Aim: The purpose of this study is to obtain data differentiation from all of the roselle extract obtained from various regions, identify from which region roselle extract has similar group with roselle standard extract, and identify the relation between roselle extracts quality with soil examination parameter. Materials and Method: Roselle simplisia collections were obtained from 12 regions which were Parangtritis, Nganjuk, Kediri, Ponorogo, Blitar, Bogor, Tulungagung, Boyolali, Yogyakarta, Sukabumi, Cileunyi, dan Malang. The extraction method used was using maceration with 70% ethanol. FTIR-chemometric was utilized to analyze. Results: Based on the results showed that FTIR-chemometric method can be used to differentiate roselle extract from several locations, roselle extract obtained from Tulungagung, Boyolali, and Sukabumi were in similar group with roselle extract standard, and roselle extract obtained from Tulungagung, Boyolali, and Sukabumi had similar soil examination parameter which were Phosphorus and Magnesium.Keywords
Roselle, FTIR-chemometric, Soil parameter.References
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