Journal of Academy of Dental Education

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Immunofluorescence in Oral Dermatological Disorders-No Shiny Matter


Affiliations
1 Oral Pathology, Vinayaka Mission’s Sankarachariyar Dental College, NH-47, Sankari main road, Ariyanoor, Salem - 636308, Tamil Nadu, India
 

Dermatological diseases with underlying immunological pathosis exhibiting similar clinical manifestations have challenged even the veteran dermatologists in rendering diagnosis clinically, necessitating study of the skin lesions with immunofluroscence. The technique is similar to immunochemistry where instead of enzymes antibodies are labelled with a fluorescent dye. It probes the study of the cell and molecular biology. Immunofluorescence permit early diagnosis, treatment and subsequent monitoring of disease activity in patient with potentially life threatening disease. It is widely used in the field of vesiculo-bullous lesions and other related oral dermatological disorders by demonstrating antibodies either in biopsy tissue or in the serum separated from blood collected from the patients.

Keywords

Epidermolysis Bullosa, Immunofluorescence, Lichen Planus, Membrane Pemphigoid, Mucous, Pemphigus, Pemphigoid.
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  • Immunofluorescence in Oral Dermatological Disorders-No Shiny Matter

Abstract Views: 240  |  PDF Views: 192

Authors

Umamaheswari Kanniah
Oral Pathology, Vinayaka Mission’s Sankarachariyar Dental College, NH-47, Sankari main road, Ariyanoor, Salem - 636308, Tamil Nadu, India
Unnimaya Varghese
Oral Pathology, Vinayaka Mission’s Sankarachariyar Dental College, NH-47, Sankari main road, Ariyanoor, Salem - 636308, Tamil Nadu, India
V. S. Sruthi
Oral Pathology, Vinayaka Mission’s Sankarachariyar Dental College, NH-47, Sankari main road, Ariyanoor, Salem - 636308, Tamil Nadu, India
Mathew Jacob
Oral Pathology, Vinayaka Mission’s Sankarachariyar Dental College, NH-47, Sankari main road, Ariyanoor, Salem - 636308, Tamil Nadu, India

Abstract


Dermatological diseases with underlying immunological pathosis exhibiting similar clinical manifestations have challenged even the veteran dermatologists in rendering diagnosis clinically, necessitating study of the skin lesions with immunofluroscence. The technique is similar to immunochemistry where instead of enzymes antibodies are labelled with a fluorescent dye. It probes the study of the cell and molecular biology. Immunofluorescence permit early diagnosis, treatment and subsequent monitoring of disease activity in patient with potentially life threatening disease. It is widely used in the field of vesiculo-bullous lesions and other related oral dermatological disorders by demonstrating antibodies either in biopsy tissue or in the serum separated from blood collected from the patients.

Keywords


Epidermolysis Bullosa, Immunofluorescence, Lichen Planus, Membrane Pemphigoid, Mucous, Pemphigus, Pemphigoid.

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DOI: https://doi.org/10.18311/jade%2F2016%2F158645