Indian Journal of Chemical Technology

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Preparation and Characterization of Hybrid Nanofibrous Polymer Scaffolds For Tissue Engineering Applications


Affiliations
1 Department of Petrochemical Technology, Central Institute of Petrochemical Engineering and Technology (CIPET), Chennai 600 032,, India
2 CIPET: School for Advanced Research in Polymers (SARP) - APDDRL, Bengaluru 562 149, India
 

This paper endeavours towards the scientific study of infusion of silver nanoparticles (Ag NPs) into biodegradable polymer scaffold for bone tissue engineering. Highly biocompatible Ag NPs have been synthesized using chitosan as stabilizing and reducing agent. The synthesized Ag NPs have been uniformly suspended in polyvinyl alcohol (PVA) and sodium alginate (SA) solution and nanofibrous mat like scaffolds have been fabricated using electrospinning process. The proposed process of infusing Ag NPs in PVA/SA medium resulted in nanofibers of smaller diameter and reduced pore size resulted in high surface area which is due to electrostatic charge interaction of Ag NPs during electrospinning. Thus, the improved surface area has facilitated better growth of extracellular matrix (ECM) compared to traditional coating method. The effect of coating nanoparticles on prepared polymeric scaffolds proves less than infusion of nanoparticles prior to electrospinning.

Keywords

Bone tissue engineering, Chitosan, Electrospinning, Silver, Sodium alginate
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  • Preparation and Characterization of Hybrid Nanofibrous Polymer Scaffolds For Tissue Engineering Applications

Abstract Views: 135  |  PDF Views: 102

Authors

Gurumoorthi Ramar
Department of Petrochemical Technology, Central Institute of Petrochemical Engineering and Technology (CIPET), Chennai 600 032,, India
Sangeetha Ashokumar
Department of Petrochemical Technology, Central Institute of Petrochemical Engineering and Technology (CIPET), Chennai 600 032,, India
Bhuvana K Periyasamy
Department of Petrochemical Technology, Central Institute of Petrochemical Engineering and Technology (CIPET), Chennai 600 032,, India
R Joseph Bensingh
CIPET: School for Advanced Research in Polymers (SARP) - APDDRL, Bengaluru 562 149, India

Abstract


This paper endeavours towards the scientific study of infusion of silver nanoparticles (Ag NPs) into biodegradable polymer scaffold for bone tissue engineering. Highly biocompatible Ag NPs have been synthesized using chitosan as stabilizing and reducing agent. The synthesized Ag NPs have been uniformly suspended in polyvinyl alcohol (PVA) and sodium alginate (SA) solution and nanofibrous mat like scaffolds have been fabricated using electrospinning process. The proposed process of infusing Ag NPs in PVA/SA medium resulted in nanofibers of smaller diameter and reduced pore size resulted in high surface area which is due to electrostatic charge interaction of Ag NPs during electrospinning. Thus, the improved surface area has facilitated better growth of extracellular matrix (ECM) compared to traditional coating method. The effect of coating nanoparticles on prepared polymeric scaffolds proves less than infusion of nanoparticles prior to electrospinning.

Keywords


Bone tissue engineering, Chitosan, Electrospinning, Silver, Sodium alginate

References