Indian Journal of Chemical Technology

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In-vitro Studies of Bioactive Nanoemulgel from Agro-Waste and Mathematical Modeling of Drug Release


Affiliations
1 Adhiyamaan College of Engineering, Department of Chemical Engineering, Hosur-635 130, Tamil Nadu, India
2 Coimbatore Institute of Technology, Department of Chemical Engineering, Coimbatore-640 014, Tamil Nadu, India

A comparison of the bioactive components present in the 1:16 (% w/v) ethanol extracts of rinds of Citrus limetta, Punica granatum and leaves of Musaa cuminata have been carried out. The leaf extract of Musaacuminata revealed the presence of about 88% of components with antimicrobial activities. The current work focuses on a comparative study of fitness of empirical (Zero, First, Higuchi) and semi empirical (Ritger-Peppas) mathematical models to describe the drug release mechanism of the formulated nanoemulgel. In-vitro studies are carried out, of which B1 posed 96% of cumulative drug release. The results revealed that Higuchi model fitted the best for the optimized formulation of B1, B2, and B3 with higher regression coefficient (R<sup>2</sup> values of 0.99). The formulation followed the Fickian type of release for the bioactive component, which can be used for treating the fungal infection.

Keywords

Agro-wastes, Bioactive component, Drug delivery, Release mechanism
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  • In-vitro Studies of Bioactive Nanoemulgel from Agro-Waste and Mathematical Modeling of Drug Release

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Authors

Gaanapriya V
Adhiyamaan College of Engineering, Department of Chemical Engineering, Hosur-635 130, Tamil Nadu, India
Sivakumar V M
Coimbatore Institute of Technology, Department of Chemical Engineering, Coimbatore-640 014, Tamil Nadu, India
Thirumarimurugan M
Coimbatore Institute of Technology, Department of Chemical Engineering, Coimbatore-640 014, Tamil Nadu, India

Abstract


A comparison of the bioactive components present in the 1:16 (% w/v) ethanol extracts of rinds of Citrus limetta, Punica granatum and leaves of Musaa cuminata have been carried out. The leaf extract of Musaacuminata revealed the presence of about 88% of components with antimicrobial activities. The current work focuses on a comparative study of fitness of empirical (Zero, First, Higuchi) and semi empirical (Ritger-Peppas) mathematical models to describe the drug release mechanism of the formulated nanoemulgel. In-vitro studies are carried out, of which B1 posed 96% of cumulative drug release. The results revealed that Higuchi model fitted the best for the optimized formulation of B1, B2, and B3 with higher regression coefficient (R<sup>2</sup> values of 0.99). The formulation followed the Fickian type of release for the bioactive component, which can be used for treating the fungal infection.

Keywords


Agro-wastes, Bioactive component, Drug delivery, Release mechanism