Antioxidant Property of Spirulina and L iv -52 Against Lead Induced Toxicity in Albino Rats

Objective: The present study was carried out to evaluate the antioxidant property of spirulina and Liv-52 against lead induced toxicity in albino rats. Materials and methods: The antioxidant property of spirulina and Liv-52 was investigated by using lead acetate to induce toxicity in albino rats. The extent of lipid peroxidaiton in terms of thiobarbituric acid reactive susbstances (TBARS), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and reduced glutathine (GSH) were assayed in the liver and kidney homogenate. Results: Oral administration of lead (10mg/kg body weight/day) as lead acetate for 30 days resulted in a significant increase (P<0.01) in the level thiobarbituric acid reactive substances (TBARS) and a decrease in the level of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) when compared to normal control. Administration of both spirulina and Liv-52 produced a pronounced protective effect (P< 0.01) in respect to these parameters when compared to their individual administration in lead intoxicated rats. Conclusion: The results of the present study suggested the antioxidant and protective efficacy of spirulina and Liv-52 against lead induced toxicity in albino rats.