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Prajapati, Disha
- Development and Evaluation of a Polyherbal Tablet for Polycystic Ovarian Syndrome (PCOS)
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Authors
Affiliations
1 Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391110, Gujarat, IN
2 Parul Institute of Pharmacy, Parul University, Vadodara - 391110, Gujarat, IN
1 Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391110, Gujarat, IN
2 Parul Institute of Pharmacy, Parul University, Vadodara - 391110, Gujarat, IN
Source
Journal of Natural Remedies, Vol 22, No 2 (2022), Pagination: 160 - 174Abstract
The main objective of the present study was to develop and evaluate polyherbal tablet for the treatment of Polycystic Ovarian Syndrome (PCOS). For the formulation of tablet, the herbs were selected based on the concepts of pathophysiology and Ayurvedic perspective of the disease. The extracts of T. foenum graceum, C. longa, B. aristata, S. asoka, B. variegata and Guggul purified in cow’s urine was used for the preparation of polyherbal tablet. The physicochemical, phytochemical evaluation and quantification of markers by HPTLC of crude drugs and extracts were performed. The guggul was used as binder in different proportion for the preparation of tablet. Pre-formulation study of the powder blend and post compression evaluation of tablet was done by various parameters like weight variation, friability, hardness, thickness, diameter, disintegration time, in-vitro dissolution and accelerated stability study. The physicochemical evaluations of crude drugs yielded results which were in accordance with the monograph’s standard values. The phytochemical analysis of the extracts revealed the presence of variety of phytoconstituents. From the results of HPTLC quantification the amount of curcumin (7.14%) in C. longa, diosgenin (40.6%) in T. foenum graceum ,T. foenum graceum, berberine hydrochloride (4.83%) in B. aristata, catechin (3.48%) in S. asoka, lupeol (0.11%) in B. variegata and Z-guggulsterone (0.140%) and E-guggulsterone (0.146%) in purified guggul was found. The micrometrics of the powder blend of all the formulations showed good flow properties. Formulation F3 showed better results compared to other formulations in post compression evaluation. Accelerated stability study showed that the formulation F3 was stable during the course of study.Keywords
Micromeritics, Polyherbal Formulation, Polycystic Ovarian Syndrome, Physicochemical EvaluationFull Text
References
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- HPTLC Method Development and Validation for Simultaneous Estimation of Berberine, Ellagic Acid and Ferulic Acid in Amrtadi Churna
Abstract Views :83 |
PDF Views:83
Authors
Affiliations
1 Parul Institute of Pharmacy and Research, Parul University, Limda, Waghodia, Vadodara - 391760, Gujarat, IN
1 Parul Institute of Pharmacy and Research, Parul University, Limda, Waghodia, Vadodara - 391760, Gujarat, IN
Source
Journal of Natural Remedies, Vol 22, No 4 (2022), Pagination: 649-657Abstract
The objective of the current study was to develop a new simple and precise High Performance Thin Layer Chromatography (HPTLC) method for standardization of three biomarkers i.e., berberine, ellagic acid and ferulic acid in Amrtadi churna. Amrtadi churna is mainly used for hyperacidity and contains dried plant parts of Gokshur, Amla and Guduchi. The method was developed and validated using precoated silica gel at 60 F254 as the stationary phase and toluene:ethyl acetate:formic acid:methanol (6:6:1.6:0.4, v/v/v/v) as the mobile phase. The detection and quantification were performed at 319 nm and the Rf value obtained was 0.35±2 for berberine, 0.5±2 for ellagic acid and 0.74±2 for ferulic acid. The method was validated as per ICH guidelines in terms of linearity, precision, specificity, accuracy and robustness.Keywords
Amla, Gokshur, Guduchi, ICH, StandardizationFull Text
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- Development and Validation of HPTLC Method for Simultaneous Estimation of Piperine and Scopoletin in Ajmodadi churna
Abstract Views :97 |
PDF Views:68
Authors
Affiliations
1 Parul Institute of Pharmacy and Research, Parul University, Limda, Waghodia - 391760, Vadodara, Gujarat, IN
1 Parul Institute of Pharmacy and Research, Parul University, Limda, Waghodia - 391760, Vadodara, Gujarat, IN
Source
Journal of Natural Remedies, Vol 23, No 1 (2023), Pagination: 143-148Abstract
In this recent study, several trials were made to develop a HPTLC method for quantification of scopoletin and piperine in the Ajmodadi formulation. HPTLC was done on pre-coated silica gel 60 F254 plates with a mobile phase of toluene:ethyl acetate:methanol:formic acid (3.9:3.9:0.3:1.7 v/v/v/v). The retardation factors for scopoletin 0.75 and for piperine was 0.86 and found a good and defined resolution peak. Densitometer analysis of scopoletin and piperine was carried out at 335 wavelength (nm). The developed method was validated as reported in ICH guidelines (Q2R1). A linearity study shows that scopoletin and piperine was linear, and the recovery studies revealed a recovery in between 98-102 % as per guideline. This method was established to be rapid, delicate, accurate and specific, thus, these methods may be used in the quantification of the drug in any polyherbal formulation.Keywords
Ajmodadi Churna, HPTLC, Piperine, Scopoletin.Full Text
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