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Selvaraj, Jubie
- In silico Screening of Chemical Constituents in Rasam as a Beneficial Supplementary Treatment for Novel Coronavirus
Abstract Views :460 |
PDF Views:301
Authors
M. K. Mohan Maruga Raja
1,
Jubie Selvaraj
2,
S. S. Pottabathula
2,
G. V. Anjana
3,
M. K. Kathiravan
3
Affiliations
1 Department of Pharmacognosy and Phytochemistry, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat – 391760, IN
2 Department of Pharmaceutical Chemistry, J.S.S. College of Pharmacy, Udhagamandalam, Tamil Nadu – 643001, IN
3 Dr. APJ Abdul Kalam Research Laboratory, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu – 603203, IN
1 Department of Pharmacognosy and Phytochemistry, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat – 391760, IN
2 Department of Pharmaceutical Chemistry, J.S.S. College of Pharmacy, Udhagamandalam, Tamil Nadu – 643001, IN
3 Dr. APJ Abdul Kalam Research Laboratory, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu – 603203, IN
Source
Journal of Natural Remedies, Vol 21, No 4 (2021), Pagination: 357-365Abstract
Context: The novel coronavirus named as COVID-19 (SARS-CoV-2) from its origin in Hubei spread across the continent in a short period of six months’ time. Till date there is no drug to cure the novel corona virus SARS-CoV-2. Earlier studies on SARS-CoV-1 suggests that interleukin 6 (IL-6) and Interleukin 8 (IL-8) were in the higher levels indicating the key role of IL. Aim: Molecular simulation studies were carried out on the selected 24 chemical constituents present in rasam against IL-6 to identify the key interaction between the amino acid residues and their chemical structure. Materials and Methods: A library of 24 chemical constituents was sketched using Chem Sketch programming 8.0. The 3D structures of ligands were retrieved in mol format in Maestro v 11.3 and the ligands were optimized utilizing ligprep (4.3) module (Schrödinger 2018-1). Results: One of the chemical constituents sinigrin a glucosinolate emerged as top scorer with a GLIDE score of -6.333. It was apparent from the examination, that the Van der Waals (ΔG bindvdW) and coulomb energy interactions were major great contributors. The structural diversity of sinigrin from the rest of other chemical constituents in rasam led to significantly better interaction with amino acid residues. Conclusion: The study identifies sinigrin, as one of the active constituents in rasam possessing good binding affinity against IL-6 which can be used as a dietary supplement and can be used as a control measure to fight against Covid-19.Keywords
Functional Food, IL-6 Inhibitor, SARS-CoV-2, Sinigrin, Tartaric Acid.References
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- Devarajan A, Mohanmarugaraja MK. A comprehensive review on rasam: A South Indian traditional functional food. Pharmacognosy Reviews. 2017; 11(22):73–82. https://doi.org/10.4103/phrev.phrev_13_17. PMid:28989243. PMCid:PMC5628526
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- Devarajan A, Mohanmarugaraja MK. Identification and analysis of chemical constituents of rasam by gas chromatography-mass spectrometry (GC-MS). Res J Pharm Technol. 2017; 10(12):4183–7. https://doi.org/10.5958/0974-360X.2017.00763.6
- Devarajan A, Mohanmarugaraja MK. Cytotoxic, antimitotic, and antiproliferation studies on rasam: A south Indian traditional functional food. Pharmacogn Mag. 2017; 13(Suppl 3):S452–7. https://doi.org/10. 4103/pm.pm_138_17. PMid:29142398.PMCid:PMC 5669081
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- Chemopreventive Potential of Phytoestrogens on Hormone-Sensitive Cancer - An Updated Review
Abstract Views :93 |
PDF Views:70
Authors
Affiliations
1 Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris - 643001, Tamil Nadu, IN
2 Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris - 643001, Tamil Nadu, IN
3 Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris - 643001, Tamil Nadu, IN
1 Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris - 643001, Tamil Nadu, IN
2 Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris - 643001, Tamil Nadu, IN
3 Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris - 643001, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 23, No 1 (2023), Pagination: 23-33Abstract
Hormone-dependent cancers contribute to the majority of cancer deaths in women. Treatment options for hormonal cancer such as breast, endometrial, prostate, and ovarian cancer aim at inhibiting key signalling pathways and hormones responsible for cell proliferation. Hormonal therapies in the long run cause musculoskeletal disorders, Disease reoccurrence, and drug resistance. There is a need for new alternative therapies to prevent and treat hormonal carcinomas. Phytoestrogens, a naturally occurring polyphenol have potent effects on hormonal cancers due to their estrogenic effects. Evidence suggests that phytoestrogens exert their apoptotic potential by interfering with steroidogenesis, gene expressions, and down-regulation of Protein Tyrosine Kinases, Matrix Metalloproteinases. They also act as topo-poisons. This review explains the key mechanisms of phytoestrogens in inhibiting cell proliferation in hormonal cancers by evidence from recent clinical studies, meta-analyses, and cohort study reports. Phytoestrogens have multi-target potential with both preventive and treatment properties on cancer cell lines. Combination therapies with phytoestrogens are more beneficial in controlling cell progression. Hence further research is required to explore their epigenetic properties on tumour suppressor genes which stay an important target in cancer research.Keywords
Breast Cancer, Chemoprevention, Endometrial Cancer, Ovarian Cancer, Phytoestrogens.References
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