Refine your search
Collections
Journals
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Bumaasri, K.
- Insilico and Pharmacological Property Analysis of Bioactive Components from Prunus avium against Diabetics
Abstract Views :141 |
PDF Views:90
Authors
L. Veerapandi
1,
T. Nivetha
2,
R. Sinthiya
3,
N. Karunyah Amirthadharshini
4,
K. Bumaasri
4,
R. Aishwarya
4
Affiliations
1 Department of Food Technology, Saintgits College of Engineering, Kottukulam, Pathamuttom Hills, Kottayam – 686532, Kerala, IN
2 Department of Food Technology, Hindusthan College of Engineering and Technology, Coimbatore – 641050, Tamil Nadu, IN
3 Department of Food Technology, Processing Technology and Management, PSGR Krishnammal College for Women, Coimbatore – 641004, Tamil Nadu, IN
4 Department of Food Technology, Bannari Amman Institute of Technology, Sathyamangalam, Erode – 638401, Tamil Nadu, IN
1 Department of Food Technology, Saintgits College of Engineering, Kottukulam, Pathamuttom Hills, Kottayam – 686532, Kerala, IN
2 Department of Food Technology, Hindusthan College of Engineering and Technology, Coimbatore – 641050, Tamil Nadu, IN
3 Department of Food Technology, Processing Technology and Management, PSGR Krishnammal College for Women, Coimbatore – 641004, Tamil Nadu, IN
4 Department of Food Technology, Bannari Amman Institute of Technology, Sathyamangalam, Erode – 638401, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 22, No 1 (2022), Pagination: 113 - 119Abstract
Diabetes is a common metabolic disorder, which effects people across all cultures globally. Lifelong distress is the cause of this disease which has no cure as of now. Various medications available in the market are too expensive and not easily affordable by all. Rural people rely on plant based Ayurvedic medications to heal diabetes as these contain anti-diabetic compounds. These phytoconstituents/anthocyanin derivatives work with several mechanisms that involve phytoconstituent interactions and target molecules in diabetic metabolism. Molecular docking analysis aids in finding out the interaction between receptors and ligands to identify the finest interaction which suits the target. In this case, the study proposed examining the bonding interactions of anti-diabetic compounds/anthocyanin derivatives derived from medicinal plants (Pelargonidin, Cyanidin, Delphinidin, Peonidin, Petunidin, Quercetin and pancreatic alpha-amylase (4X9Y)) with the help of the computational tool. ADME/T test helps decide different pharmacological and physicochemical analysis of lead atoms, degree of adsorption inside the cell, digestion rate, solvency, blood cerebrum boundary penetrability, cancer-causing nature and so on, which are the significant essentials prior to advertising a medication. Peonidin and Quercetin was proposing the best interactions. Nonetheless, to discover a better cure for diabetes, further in-vitro/ in vivo studies have to be carried out.Keywords
Anthocyanins, Diabetes, Molecular Docking, Pancreatic alpha-amylase (4X9Y), Phytochemicals, α-amylaseFull Text
References
- ADA (2014); Diagnosis and classification of diabetes mel- litus. Diabetes Care; 37; S81–S90. https://doi.org/10.2337/ dc14-S081. PMid:24357215
- Clark CM, and Lee DA. Prevention and treatment of the complications of diabetes mellitus. N Engl J Med. 1995; 332(18):1210–121. https://doi.org/10.1056/NEJM19950504 3321807. PMid:7700316
- Tota K, Rayabarapu N, Moosa S, Talla V, Bhyravbhatla B, Rao S. InDiaMed: A comprehensive database of Indian medicinal plants for diabetes. Bioinformation. 2013; 9(7):378–80. https://doi.org/10.6026/97320630009378. PMid:23750084. PMCid:PMC3669792
- Blackhall ML, Berry R, Davies NW, Walls JT. Optimized extraction of anthocyanins from reid fruits’ Prunus avium ‘lapins’ cherries. Food Chem. 2018; 256:280–5. https://doi. org/10.1016/j.foodchem.2018.02.137. PMid:29606449
- 5. Chandrasekhar J, Madhusudhan MC, Raghavarao KSMS. Extraction of anthocyanins from redcabbage and puri- fication using adsorption. Food Bioprod. Process. 2012; 90(4):615–23. https://doi.org/10.1016/j.fbp.2012.07.004
- Korkina LG. Phenylpropanoids as naturally occurring anti- oxidants: From plant defense to human health. Cell Mol Biol. 2007; 53:15–25.
- Schmitz-Eiberger MA, Blanke MM. Bioactive components in forced sweet cherry fruit (Prunus avium L.), antioxidative capacity and allergenic potential as dependent on cultiva- tion under cover. LWT Food Sci Technol. 2012; 46:388–92. https://doi.org/10.1016/j.lwt.2011.12.015
- Serradilla MJ, Lozano M, Bernalte MJ, et al. Physico- chemical and bioactive properties evolution during ripening of “Ambrunés” sweet cherry cultivar. LWT Food Sci Technol. 2011; 44:199–205. https://doi.org/10.1016/j. lwt.2010.05.036
- Usenik V, Fabčič J, Štampar F. Sugars, organic acids, phe- nolic composition and antioxidant activity of sweet cherry (Prunus avium L.). Food Chem. 2008; 107:185–92. https://doi.org/10.1016/j.foodchem.2007.08.004
- Usenik V, Stampar F, Petkovsek MM, Kastelec D. The effect of fruit size and fruit colour on chemical composition in “Kordia” sweet cherry (Prunus avium L.). J Food Compos Anal. 2015; 38:121–30. https://doi.org/10.1016/j. jfca.2014.10.007
- Kaushik D, Kumar A, Kaushik P, Rana AC. Analgesic and anti-inflammatory activity of Pinus roxburghii sarg. Adv Pharmacol Sci. 2012; 245431. https://doi. org/10.1155/2012/245431. PMid:22761611. PMCid:PMC3 384912
- Marles RJ, Farnsworth NR. Anti-diabetic plants and their active constituents. Phytomedicine. 1995; 2(2):137–89. https://doi.org/10.1016/S0944-7113(11)80059-0
- Anjana RM, Pradeepa R, Deepa M, et al. ICMR-INDIAB collaborative study group: Prevalence of diabetes and prediabetes (impaired fasting glucose or/and impaired glucose tolerance) in rural and urban India: Phase 1 results of the Indian Council of Medical Research- INdiaDIABetes (INDIAB) study. Diabetologia. 2011; 54(12):3022–7. https:// doi.org/10.1007/s00125-011-2291-5. PMid:21959957
- Ferreira L, dos Santos R, Oliva G, Andricopulo A. Molecular docking and structure-based drug design strategies. Molecules. 2015; 20(7):13384–421. https:// doi.org/10.3390/molecules200713384. PMid:26205061. PMCid:PMC6332083
- Suganya J, Viswanathan T, Radha M, Marimuthu N. In silico molecular docking studies to investigate interactions of natural camptothecin molecule with diabetic enzymes. Research J. Pharm. and Tech. 2017; 10(9):2917–22. https:// doi.org/10.5958/0974-360X.2017.00515.7
- Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and develop- ment settings. Adv. Drug Deliv. Rev. 1997; 23(1–3):3–25. https://doi.org/10.1016/S0169-409X(96)00423-1
- Dearden JC. In silico prediction of ADMET properties: How far have we come? Expert Opin Drug Metab Toxicol. 2007; 3(5):635–9. https://doi.org/10.1517/17425255.3.5.635. PMid:17916052
- Wang J, Skolnik S. Recent advances in physicochemical and ADMET profiling in drug discovery; Chemistry & biodiversity. 2009; 6(11):1887–99. https://doi.org/10.1002/ cbdv.200900117. PMid:19937823
- Reddy GD, Kumar KNVP, Duganath N, Divya R, Amitha K. ADMET docking studies and binding energy calculations of some novel ACE inhibitors for the treatment of diabetic nephropathy. Int J. Drug Dev. Res. 2012; 4:268–82.
- Guttula S, Rao AA, Sridhar GR, Chakravarthy MS. Protein ligand interaction analysis an insilico potential drug tar- get identification in diabetes mellitus and nephropathy. J. Bioinform. Seq. Anal. 2011; 3(5):95–9.