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Veerapandi, L.
- Evaluation and Comparative Study of Anti- diabetic Activity of Anthocyanins Derived from Various Natural Sources
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Authors
Affiliations
1 Bannari Amman Institute of Technology, Erode – 638401, Tamil Nadu, IN
1 Bannari Amman Institute of Technology, Erode – 638401, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 22, No 1 (2022), Pagination: 105 - 111Abstract
Diabetes is a common disorder due to metabolism, more or less people of cultural groups in the region globally. This disease is caused due to the lifelong distress and has no cure as of now. Naturopathy / Plant based chemical antibiotics are proven safe than the synthetic chemicals that are artificially synthesized. In this study, the total anthocyanin content and their antimicrobial activity was estimated for the samples. The study revealed the anti-diabetic properties of anthocyanin from several sources such as strawberries (Fragaria ananassa), cherries (Prunus avium), pomegranate (Punica granatum), grapes (Vitis vinifera), flame of forest flowers (Canna indica), hibiscus flowers (Hibiscus rosa-sinensis) and guava leaves (Psidium guajava). Extraction has been done by using ethanol as a base and inhibition studies have been conducted. The source ‘Canna indica’ showed huge amount of anthocyanin content of 814.6 mg/100g and other sources showed varied amount of anthocyanin content. Prunus avium fruits showed maximum antidiabetic activity. The total phenolic and anthocyanin contents with its antidiabetic activity for different sources using acidified ethanol were studied.
Keywords
Anthocyanin, Antimicrobial Activity, Cherries, Grapes, Hibiscus Flowers, Naturopathy, Pomegranate, StrawberriesFull Text
References
- Anderson OM. Anthocyanin occurrences and analy- sis. Proceedings of the International Workshop on Anthocyanins: Research and Development of Anthocyanins, Adelaide, South Australia; 2002.
- Kahkonen M, Meier C, Hopia A, Oksman-Caldentey KM. Antimicrobial properties of phenolic compounds from berries. J. Appl. Microbiol. 2001:494–507. https://doi. org/10.1046/j.1365-2672.2001.01271.x. PMid:11309059
- Sama K, Sivaraj R, Rajiv P. In vitro antidiabetic activity of anthocyanin extract of Asystasia gangetica (Chinese violet) flower. 2013; 3:88–92.
- Ioanaignat, Volf I, Popa VI. A crictical review of methods for characterization of polyphenolic compounds in fruits and vegetables. Food Chem. 2010:126–32. https://doi. org/10.1016/j.foodchem.2010.12.026. PMid:25213963
- Diana A, Garban G, Garban Z. The anthocyanins biologi- cally-active substances of food and pharmaceutic interest. Ann. Univ. Dunarea Jos Galati Fascicle VI: Food Technol. 2003; VI:106–15.
- Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Concentrations of anthocyanins in common foods in the United States and estimation of normal con- sumption. J. Agric. Food. Chem. 2006; 54:4069–75. https:// doi.org/10.1021/jf060300l. PMid:16719536
- Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Concentrations of Anthocyanins in com- mon foods in the United States and Estimation of Normal Consumption. 2006; 54:4069–75. https://doi.org/10.1021/ jf060300l. PMid:16719536
- Castaneda-ovando A. Structural identification of antho- cyanins’ Food Chem. 2009; 113:859–71. https://doi. org/10.1016/j.foodchem.2008.09.001
- Chalker-Scott L. Environmental significance of anthocya- nins in plant-stress responses. Photochem. Photobiol. 1999; 70:1–9. https://doi.org/10.1111/j.1751-1097.1999.tb01944.x
- Howell AB, Vorsa N, Marderosian AD, Foo LY. Inhibition of the adherence of P-ambriated Escherichia coli to uro- epithe- lial surfaces by proanthycyanidin extracts from cranberries. N Engl J Med. 1998; 339:1085–96. https://doi.org/10.1056/ NEJM199810083391516. PMid:9767006
- Li R, Wang P, Guo Q, Wang Z. Anthocyanin composi- tion and content of the Vaccinium uliginosum berry. Food Chem. 2011; 125:116–20. https://doi.org/10.1016/j.foodchem.2010.08.046
- 12. Puupponen-Pimia R, Nohynek L, Meier C, Kahkonen M,
- Heinonen M, Hopia A, Oksman-Caldentey KM. Antimicrobial properties of phenolic compounds from berries. Journal of Applied Microbiology. 2001; 90:494– 507. https://doi.org/10.1046/j.1365-2672.2001.01271.x. PMid:11309059
- Cushnie TPT, Lamb AJ. Antimicrobial activity of flavo- noids. International Journal of Antimicrobial Agents. 2005; 26:343–56. https://doi.org/10.1016/j.ijantimicag.2005. 09.002. PMid:16323269. PMCid:PMC7127073
- Tanaka Y, Sasaki N, Ohmiya A. Biosynthesis of plant pig- ments: anthocyanins, betalains and carotenoids. Plant J. 2008; 54:733–49. https://doi.org/10.1111/j.1365-313X.2008. 03447.x. PMid:18476875
- GaoH,HuangYN,GaoB,XuPY,InagakiC,KawabataJ.‘α- Glucosidase inhibitory effect by the flower buds of Tussilago farfara’ L. Food Chem. 2008; 106:1195–201. https://doi. org/10.1016/j.foodchem.2007.07.064
- Griffin PJ, Fogarty WM. Preliminary observation of starch degrading system elaborated by Bacillus poly- myxa. Biochem. Soc. Trans. 1973; 1:397–400. https://doi. org/10.1042/bst0010397
- Jakobek L, Seruga M, Medvidovi M, Novak I. Anthocyanin content and antioxidant activity of various fruit juices. Deutsche Lebensmittel-Rundschau: Zeitschrift für Lebensmittelkunde und Lebensmittelrecht. 2007; 103:456– 72.
- Myrbrack K., Neumuller, G. Chemistry and mechanism of action 1st ed., Vol.1. Academic. 1950; 226–28.
- Vankar PS, Srivastava J. Comparative study of antioxidant activity, phenol and flavonoid contents in red, yellow variet- ies of Canna indica and Hibiscus rosasinensis, prospective natural food dyes. Int. J. Food Eng. 2008; 4:1–15. https://doi. org/10.2202/1556-3758.1232
- Philip T. An anthocyanin recovery system from grape wastes. J. Food Sci. 1974; 39:859. https://doi. org/10.1111/j.1365-2621.1974.tb17999.x
- Tamimi M, Santiago M, Blancojerez L. Comparative study of anthocyanins. JOMS. 2007:223–9.
- Bernfeld P. [17] Amylases, α and β. Method. Enzymol. 1955; 1:149–58. https://doi.org/10.1016/0076-6879(55)01021-5
- Bridle P, Garcia-Viguera C. Analysis of anthocyanins in strawberries and elderberries A comparison of capillary zone electrophoresis and HPLC. Food Chem. 1997; 59:299– 304. https://doi.org/10.1016/S0308-8146(96)00176-8
- Cacace JE, Mazza G. Optimization of extraction of anthocy- anins from black currants with aqueous ethanol. J. Food Sci. 2003; 68:240–8. https://doi.org/10.1111/j.1365-2621.2003. tb14146.x
- Da Silva, Lopes F, et al. Anthocyanin pigments in straw- berry. LWT LWT-Food Sci Technol. 2007; 40:374–82. https://doi.org/10.1016/j.lwt.2005.09.018
- Filimon RV, Beceanu M, Niculaua, Cristina. Arion Cercetari agronomice. Moldova. 2011; 44:81–91. https://doi. org/10.2478/v10298-012-0027-4
- Fischer UA, Carle R, Kammerer DR. Identification and quantification of phenolic compounds from pome- granate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD-ESI/MSn. Food Chem. 2011; 127:807–21. https://doi.org/10.1016/j.food- chem.2010.12.156. PMid:23140740
- Garcia-Viguera C, Zafrilla P, Tomas-Barberan FT. The use of acetone as an extraction solvent for anthocyanins from straw- berry fruits. Phytochem Anal. 1998; 9:274–7. https://doi. org/10.1002/(SICI)1099-1565(199811/12)9:6<274::AID- PCA416>3.0.CO;2-G
- Miguel G, Fontes C, Antunes D, Neves A, Martins D. ‘Anthocyanin concentration of Assaria pomegran- ate fruits during different cold storage conditions. J. Biomed. Biotech. 2004; 5:338–42. https://doi.org/10.1155/ S1110724304403076. PMid:15577199. PMCid:PMC1082890
- Wang Hui, Yang-Ji Du, Song H. α-Glucosidase and α-amylase inhibitory activities of guava leaves. Food Chem. 2010; 123:6–13. https://doi.org/10.1016/j.food- chem.2010.03.088
- Zhao X, Yuan Z, Fang Y. Characterization and evaluation of major anthocyanins in pomegranate (Punica granatum L.) peel of different cultivars and their development phases. European Food Research and Technology. 2012:198–295
- Yoshida Y, Koyama N, Tamura H. Color and anthocy- anin composition of strawberry fruit changes during fruit development and differences among cultivars, with special reference to the occurrence of pelargonidin 3-malonylglu- coside. J. Jpn. Soc. Hortic. Sci. 2002; 71:355–61. https://doi. org/10.2503/jjshs.71.355
- Merken HM, Beecher GR. Liquid chromatographic method for separation and quantification of anthocyanins. J. Agric Food Chem. 2000; 48:577–99. https://doi.org/10.1021/ jf990872o. PMid:10725120
- Mozetič Branka, Trebše P. Identification of sweet cherry anthocyanins and hydroxycinnamic acids using HPLC cou- pled with DAD and MS detector’ Acta Chim. Slov. 2004; 51:151–8.
- Insilico and Pharmacological Property Analysis of Bioactive Components from Prunus avium against Diabetics
Abstract Views :136 |
PDF Views:85
Authors
L. Veerapandi
1,
T. Nivetha
2,
R. Sinthiya
3,
N. Karunyah Amirthadharshini
4,
K. Bumaasri
4,
R. Aishwarya
4
Affiliations
1 Department of Food Technology, Saintgits College of Engineering, Kottukulam, Pathamuttom Hills, Kottayam – 686532, Kerala, IN
2 Department of Food Technology, Hindusthan College of Engineering and Technology, Coimbatore – 641050, Tamil Nadu, IN
3 Department of Food Technology, Processing Technology and Management, PSGR Krishnammal College for Women, Coimbatore – 641004, Tamil Nadu, IN
4 Department of Food Technology, Bannari Amman Institute of Technology, Sathyamangalam, Erode – 638401, Tamil Nadu, IN
1 Department of Food Technology, Saintgits College of Engineering, Kottukulam, Pathamuttom Hills, Kottayam – 686532, Kerala, IN
2 Department of Food Technology, Hindusthan College of Engineering and Technology, Coimbatore – 641050, Tamil Nadu, IN
3 Department of Food Technology, Processing Technology and Management, PSGR Krishnammal College for Women, Coimbatore – 641004, Tamil Nadu, IN
4 Department of Food Technology, Bannari Amman Institute of Technology, Sathyamangalam, Erode – 638401, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 22, No 1 (2022), Pagination: 113 - 119Abstract
Diabetes is a common metabolic disorder, which effects people across all cultures globally. Lifelong distress is the cause of this disease which has no cure as of now. Various medications available in the market are too expensive and not easily affordable by all. Rural people rely on plant based Ayurvedic medications to heal diabetes as these contain anti-diabetic compounds. These phytoconstituents/anthocyanin derivatives work with several mechanisms that involve phytoconstituent interactions and target molecules in diabetic metabolism. Molecular docking analysis aids in finding out the interaction between receptors and ligands to identify the finest interaction which suits the target. In this case, the study proposed examining the bonding interactions of anti-diabetic compounds/anthocyanin derivatives derived from medicinal plants (Pelargonidin, Cyanidin, Delphinidin, Peonidin, Petunidin, Quercetin and pancreatic alpha-amylase (4X9Y)) with the help of the computational tool. ADME/T test helps decide different pharmacological and physicochemical analysis of lead atoms, degree of adsorption inside the cell, digestion rate, solvency, blood cerebrum boundary penetrability, cancer-causing nature and so on, which are the significant essentials prior to advertising a medication. Peonidin and Quercetin was proposing the best interactions. Nonetheless, to discover a better cure for diabetes, further in-vitro/ in vivo studies have to be carried out.Keywords
Anthocyanins, Diabetes, Molecular Docking, Pancreatic alpha-amylase (4X9Y), Phytochemicals, α-amylaseFull Text
References
- ADA (2014); Diagnosis and classification of diabetes mel- litus. Diabetes Care; 37; S81–S90. https://doi.org/10.2337/ dc14-S081. PMid:24357215
- Clark CM, and Lee DA. Prevention and treatment of the complications of diabetes mellitus. N Engl J Med. 1995; 332(18):1210–121. https://doi.org/10.1056/NEJM19950504 3321807. PMid:7700316
- Tota K, Rayabarapu N, Moosa S, Talla V, Bhyravbhatla B, Rao S. InDiaMed: A comprehensive database of Indian medicinal plants for diabetes. Bioinformation. 2013; 9(7):378–80. https://doi.org/10.6026/97320630009378. PMid:23750084. PMCid:PMC3669792
- Blackhall ML, Berry R, Davies NW, Walls JT. Optimized extraction of anthocyanins from reid fruits’ Prunus avium ‘lapins’ cherries. Food Chem. 2018; 256:280–5. https://doi. org/10.1016/j.foodchem.2018.02.137. PMid:29606449
- 5. Chandrasekhar J, Madhusudhan MC, Raghavarao KSMS. Extraction of anthocyanins from redcabbage and puri- fication using adsorption. Food Bioprod. Process. 2012; 90(4):615–23. https://doi.org/10.1016/j.fbp.2012.07.004
- Korkina LG. Phenylpropanoids as naturally occurring anti- oxidants: From plant defense to human health. Cell Mol Biol. 2007; 53:15–25.
- Schmitz-Eiberger MA, Blanke MM. Bioactive components in forced sweet cherry fruit (Prunus avium L.), antioxidative capacity and allergenic potential as dependent on cultiva- tion under cover. LWT Food Sci Technol. 2012; 46:388–92. https://doi.org/10.1016/j.lwt.2011.12.015
- Serradilla MJ, Lozano M, Bernalte MJ, et al. Physico- chemical and bioactive properties evolution during ripening of “Ambrunés” sweet cherry cultivar. LWT Food Sci Technol. 2011; 44:199–205. https://doi.org/10.1016/j. lwt.2010.05.036
- Usenik V, Fabčič J, Štampar F. Sugars, organic acids, phe- nolic composition and antioxidant activity of sweet cherry (Prunus avium L.). Food Chem. 2008; 107:185–92. https://doi.org/10.1016/j.foodchem.2007.08.004
- Usenik V, Stampar F, Petkovsek MM, Kastelec D. The effect of fruit size and fruit colour on chemical composition in “Kordia” sweet cherry (Prunus avium L.). J Food Compos Anal. 2015; 38:121–30. https://doi.org/10.1016/j. jfca.2014.10.007
- Kaushik D, Kumar A, Kaushik P, Rana AC. Analgesic and anti-inflammatory activity of Pinus roxburghii sarg. Adv Pharmacol Sci. 2012; 245431. https://doi. org/10.1155/2012/245431. PMid:22761611. PMCid:PMC3 384912
- Marles RJ, Farnsworth NR. Anti-diabetic plants and their active constituents. Phytomedicine. 1995; 2(2):137–89. https://doi.org/10.1016/S0944-7113(11)80059-0
- Anjana RM, Pradeepa R, Deepa M, et al. ICMR-INDIAB collaborative study group: Prevalence of diabetes and prediabetes (impaired fasting glucose or/and impaired glucose tolerance) in rural and urban India: Phase 1 results of the Indian Council of Medical Research- INdiaDIABetes (INDIAB) study. Diabetologia. 2011; 54(12):3022–7. https:// doi.org/10.1007/s00125-011-2291-5. PMid:21959957
- Ferreira L, dos Santos R, Oliva G, Andricopulo A. Molecular docking and structure-based drug design strategies. Molecules. 2015; 20(7):13384–421. https:// doi.org/10.3390/molecules200713384. PMid:26205061. PMCid:PMC6332083
- Suganya J, Viswanathan T, Radha M, Marimuthu N. In silico molecular docking studies to investigate interactions of natural camptothecin molecule with diabetic enzymes. Research J. Pharm. and Tech. 2017; 10(9):2917–22. https:// doi.org/10.5958/0974-360X.2017.00515.7
- Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and develop- ment settings. Adv. Drug Deliv. Rev. 1997; 23(1–3):3–25. https://doi.org/10.1016/S0169-409X(96)00423-1
- Dearden JC. In silico prediction of ADMET properties: How far have we come? Expert Opin Drug Metab Toxicol. 2007; 3(5):635–9. https://doi.org/10.1517/17425255.3.5.635. PMid:17916052
- Wang J, Skolnik S. Recent advances in physicochemical and ADMET profiling in drug discovery; Chemistry & biodiversity. 2009; 6(11):1887–99. https://doi.org/10.1002/ cbdv.200900117. PMid:19937823
- Reddy GD, Kumar KNVP, Duganath N, Divya R, Amitha K. ADMET docking studies and binding energy calculations of some novel ACE inhibitors for the treatment of diabetic nephropathy. Int J. Drug Dev. Res. 2012; 4:268–82.
- Guttula S, Rao AA, Sridhar GR, Chakravarthy MS. Protein ligand interaction analysis an insilico potential drug tar- get identification in diabetes mellitus and nephropathy. J. Bioinform. Seq. Anal. 2011; 3(5):95–9.