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Journal of Natural Remedies

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2022

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Patel, Madhavi

Development and Evaluation of a Polyherbal Tablet for Polycystic Ovarian Syndrome (PCOS)

Abstract Views :201 | PDF Views:88

Authors

Disha Prajapati ¹, Madhavi Patel ², Abhay Dharamsi ²

Affiliations
1 Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391110, Gujarat, IN
2 Parul Institute of Pharmacy, Parul University, Vadodara - 391110, Gujarat, IN

Source

Journal of Natural Remedies, Vol 22, No 2 (2022), Pagination: 160 - 174

Abstract

The main objective of the present study was to develop and evaluate polyherbal tablet for the treatment of Polycystic Ovarian Syndrome (PCOS). For the formulation of tablet, the herbs were selected based on the concepts of pathophysiology and Ayurvedic perspective of the disease. The extracts of T. foenum graceum, C. longa, B. aristata, S. asoka, B. variegata and Guggul purified in cow’s urine was used for the preparation of polyherbal tablet. The physicochemical, phytochemical evaluation and quantification of markers by HPTLC of crude drugs and extracts were performed. The guggul was used as binder in different proportion for the preparation of tablet. Pre-formulation study of the powder blend and post compression evaluation of tablet was done by various parameters like weight variation, friability, hardness, thickness, diameter, disintegration time, in-vitro dissolution and accelerated stability study. The physicochemical evaluations of crude drugs yielded results which were in accordance with the monograph’s standard values. The phytochemical analysis of the extracts revealed the presence of variety of phytoconstituents. From the results of HPTLC quantification the amount of curcumin (7.14%) in C. longa, diosgenin (40.6%) in T. foenum graceum ,T. foenum graceum, berberine hydrochloride (4.83%) in B. aristata, catechin (3.48%) in S. asoka, lupeol (0.11%) in B. variegata and Z-guggulsterone (0.140%) and E-guggulsterone (0.146%) in purified guggul was found. The micrometrics of the powder blend of all the formulations showed good flow properties. Formulation F3 showed better results compared to other formulations in post compression evaluation. Accelerated stability study showed that the formulation F3 was stable during the course of study.

Keywords

Micromeritics, Polyherbal Formulation, Polycystic Ovarian Syndrome, Physicochemical Evaluation

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References

Azeemuddin M, Anturlikar SD, Onkaramurthy M, Baig MR, Ashok BK, Rao RP, et al., Effect of “dXB2030,” a polyherbal formulation, on Experimental polycystic ovary syndrome associated with hyperandrogenism. Adv Pharmacol Sci. 2019; 2019. https://doi.org/10.1155/2019/8272850. PMid:30863446. PMCid:PMC6378078

Patel MG, Prjapathi DP. Concept of polycystic ovarian syndrome: Perspectives of Ayurveda and Modern Science. Int J Pharmacogn Phytochem Res. 2017; 9(10):1363-72. https://doi.org/10.25258/phyto.

v9i10.10462

Arentz S, Abbott J, Smith C. Herbal medicine for the management of Polycystic Ovary Syndrome (PCOS). BMC Complim Altern Med. 2014; 14(2015):511-30. https://doi.org/10.1186/1472-6882-14-511.

PMid:25524718. PMCid:PMC4528347

Moorthy R, Prabhu KM, Murthy PS. Antihyperglycemic compound (gII) from fenugreek (Trigonella foenum-graecum linn.) seeds, its purification and effect in diabetes mellitus. Indian J Exp Biol. 2010; 48(11):1111-8.

Renuka C, Ramesh N, Saravanan K. Evaluation of the antidiabetic effect of Trigonella foenum-graecum seed powder on alloxan-induced diabetic albino rats. Int J Pharm Tech Res. 2009; 1(4):1580-4.

Mohammadi A, Gholamhosseinian A, Fallah H. Trigonella foenum-graecum water extract improves insulin sensitivity and stimulates PPAR and γ gene expression in high fructose-fed insulin-resistant rats. Adv Biomed Res. 2016; 5(1):54. https://doi.org/10.4103/2277-9175.178799. PMid:27110551 PMCid:PMC4817393

Swar G, Shailajan S, Menon S. Activity based evaluation of a traditional Ayurvedic medicinal plant: Saraca asoka (Roxb.) de Wilde flowers as

estrogenic agents using ovariectomized rat model. J Ethnopharmacol. 2017; 195:324-33. https://doi.org/10.1016/j.jep.2016.11.038. PMid:27884717

Cibin TR, Devi DG, Abraham A. Chemoprevention of two-stage skin cancer in vivo by Saraca asoca. Integr Cancer Ther. 2012; 11(3):279-86. https://doi.org/10.1177/1534735411413264. PMid:21771821

Jadhav AN, Bhutani KK. Ayurveda and gynecological disorders. J Ethnopharmacol. 2005; 97(1):151-9. https://doi.org/10.1016/j.jep.2004.10.020. PMid:15652289

Shahid AP, Salini S, Sasidharan N, Padikkala J, Raghavamenon AC, Babu TD. Effect of Saraca asoka(Asoka) on estradiol-induced keratinizing metaplasia in rat uterus. J Basic Clin Physiol Pharmacol. 2015; 26(5):509-15. https://doi.org/10.1515/jbcpp-2014-0124. PMid:25915082

Dhiman K. Ayurvedic intervention in the management of uterine fibroids: A Case series. AYU (An Int Q J Res Ayurveda). 2014; 35(3):303. https://doi.org/10.4103/0974-8520.153750. PMid:26664240.

PMCid:PMC4649577

Rajkapoor B, Jayakar B, Murugesh N. Antitumour activity of Bauhinia variegata on Dalton’s ascitic lymphoma. J Ethnopharmacol. 2003; 89(1):107-9. https://doi.org/10.1016/S0378-8741(03)00264-2

S R, H. P. Alternative therapies in polycystic ovarian syndrome. Insulin. 2010; 1(2):3.

Upwar N, Patel R, Waseem N, Mahobia NK. Hypoglycemic effect of methanolic extract of Berberis aristata DC stem on normal and streptozotocin induced diabetic rats. Int J Pharm Pharm Sci. 2011; 3(1):222-4.

Orio F, Muscogiuri G, Palomba S, Savastano S, Volpe A, Orio M, et al., Berberine improves reproductive features in obese Caucasian women with polycystic ovary syndrome independently of changes of insulin sensitivity. ESPEN J. 2013; 8(5):e200-4. https://doi.org/10.1016/j.clnme.2013.07.002

Razzaq FA, Khan RA, Feroz Z, Afroz S. Effect of Berberis aristata on lipid profile and coagulation parameters. African J Pharm Pharmacol. 2011;5(7):943-7.

Sidhu GS, Mani H, Gaddipati JP, Singh AK, Seth P, Banaudha KK, et al., Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen. 1999; 7(5):362-74. https://doi.org/10.1046/j.1524-475X.1999.00362.x. PMid:10564565

Reddy PS, Begum N, Mutha S, Bakshi V. Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome. Asian Pacific J Reprod. 2016; 5(2):116-22. https://doi.org/10.1016/j.apjr.2016.01.006

Edition F. the Pharmacopoeia of the Pharmacopoeia of. 2016;

on Traditional Medicine WHOP. Guidelines for the assessment of herbal medicines. World Health Organization; 1991.

Organization WH. WHO guidelines on good manufacturing practices (GMP) for herbal medicines; 2007. p. 72.

Khandelwal K. Practical pharmacognosy. Pragati Books Pvt. Ltd.; 2008.

Gupta AK, Tondon N, Sharma M. Quality standards of Indian medicinal plant medicinal plants unit: Published by Indian Council of Medical Research. New Delhi. 2008;3:99-105.

Chaube A, Dixit SK, Sharma P V. On improving the disintegration of ayurvedic pills containing guggulu. Anc Sci Life. 1995; 14(3):161-7.

Savarikar SS, Barbhind MM, Kulkarni AP. Pharmaceutical and analytical evaluation of Triphala guggul kalpa tablets J Ayurveda Integr Med. 201; 2(1):21-25.

Mohini U, Pallavi R, Shashikant D, Nilesh K. Assessment of guggul gum as a binding agent in tablet formulations. Res J Pharm Technol. 2013; 6(3): 238-9.

M Hedaoo M, Patil Bhole TPB. Narrative review of guggulu formulations of ayurveda reflecting their percentage of guggulu, pharmaceutics and pharmacology. IP Int J Compr Adv Pharmacol. 2021; 5(4):151-7. https://doi.org/10.18231/j.ijcaap. 2020.031

Khar RK. Lachman/liebermans: the theory and practice of industrial pharmacy. Cbs Publishers & Distribu; 2013.

Aulton ME, Taylor KMG. Aulton’s pharmaceutics. Des Manuf Med. 2007; 3:176-8.

Pharmacopoeia I. Government of India. Minist Heal Fam Welf. 2007; 2:1020-1.

Kushwaha SK, Kori ML. Development and evaluation of polyherbal syrup from some hepatoprotective medicinal plants. 2014; 1(1):5-11.

Balekundri A, Shahapuri A, Patil M. Poly-herbal tablet formulation by design expert tool and in vitro antilipase activity. Futur J Pharm Sci. 2020; 6(1). https://doi.org/10.1186/s43094-020-00131-0

Maurya H, Kumar T. Formulation, standardization, and evaluation of polyherbal dispersible tablet. Int J Appl Pharm. 2019; 11(1):158-67. https://doi.org/10.22159/ijap.2019v11i1.30113

Mamatha D. Formulation and evaluation of poly herbal anti-diabetic tablet dosage form. Int J Ayurvedic Herb Med. 2018; 6:2956-62. https://doi.org/10.18535/ijahm/v7i6.06

Puri D, Bhandari A, Sharma K, Sharma P. Formulation and evaluation of antihelminthic polyherbal tablets. Int J Green Pharm. 2011; 5(1):39-42.

Guideline ICHHT. Stability testing of new drug substances and products. Q1A (R2), Curr step. 2003; 4:1-24.

Phyto Vesicular Drug Delivery System: A Review

Abstract Views :83 | PDF Views:76

Authors

Kinjal Bera ¹, Madhavi Patel ¹

Affiliations
1 Department of Pharmacognosy, Parul Institute of Pharmacy, Parul University, Limda, Vadodara - 391760, Gujarat, IN

Source

Journal of Natural Remedies, Vol 22, No 4 (2022), Pagination: 503-515

Abstract

Natural phytoconstituents face challenges in exploring the in vivo effect despite having enormous in vitro therapeutic potential because of their low solubility and large complicated structures. To get over these obstacles, the phyto vesicular combination comprising phytoconstituents and phospholipid complex is effective. This review offers details on the phyto-vesicular complex, including information on the types of phytoconstituents and phospholipids, solvents, ratios of phytoconstituents to phospholipids, and evaluation factors. The review compiles information on a few medicinal plants and their active ingredients, from which phytosomes are formulated and evaluated.

Keywords

Herbal Extracts, Phospholipids, Phytoconstituents, Phyto Vesicular Complex.

Full Text

References

Mahajan RT, Chaudhari GM. A Novel Approach Towards Phytosomal Flavonoids. Pharma Science Monitor. 2012; 3(4):2079-2105.

Pawar HA, Bhangale BD. Phytosome as a novel biomedicine: A microencapsulated drug delivery system. J Bioanal Biomed. 2015; 7(1):6-12.

Sravanthi M, Krishna JS. Phytosomes: A novel drug delivery for herbal extracts. International Journal of Pharmaceutical Sciences and Research. 2013; 4(3):949-59.

Chivte PS, Pardhi VS, Joshi VA, Rani A. A review on therapeutic applications of phytosomes. Journal of Drug Delivery and Therapeutics. 2017; 7(5):17-21. https://doi. org/10.22270/jddt.v7i5.1513 DOI: https://doi.org/10.22270/jddt.v7i5.1513

Gnananath K, Nataraj KS, Rao BG. Phospholipid complex technique for superior bioavailability of phytoconstituents. Advanced pharmaceutical bulletin. 2017; 7(1):35. https:// doi.org/10.15171/apb.2017.005 DOI: https://doi.org/10.15171/apb.2017.005

Jain N, Gupta BP, Thakur N, Jain R, Banweer J, Jain DK, et al. Phytosome: a novel drug delivery system for herbal medicine. Int J Pharm Sci Drug Res. 2010; 2(4):224-8.

Rathore P, Swami G. Planterosomes: A potential phytophospholipid carriers for the bioavailability enhancement of herbal extracts. International Journal of pharmaceutical sciences and research. 2012; 3(3):737.

Lu M, Qiu Q, Luo X, Liu X, Sun J, Wang C, et al. Phytophospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents. Asian Journal of Pharmaceutical Sciences. 2019; 14(3):265-74. https://doi.org/10.1016/j.ajps.2018.05.011 DOI: https://doi.org/10.1016/j.ajps.2018.05.011

Kareparamban JA, Nikam PH, Jadhav AP, Kadam VJ. Phytosome: a novel revolution in herbal drugs. IJRPC. 2012; 2(2):299-310.

Khar R, Chakraborthy G, Saurabh M. Phytosomes: a brief overview. Journal of Pharmaceutical Research. 2016; 15(2):56-62. https://doi.org/10.18579/ jpcrkc/2016/15/2/94471

Karimi N, Ghanbarzadeh B, Hamishehkar H, Keyvani F, Pezeshki A, Gholian MM. Phytosome and liposome: the beneficial encapsulation systems in drug delivery and food application. 2015.

Dhyani A, Juyal D. Phytosomes: An advanced herbal drug delivery system. Current Trends in Biomedical Engineering and Biosciences. 2017; 3(5):74-5.https://doi.org/10.19080/ CTBEB.2017.03.555621 DOI: https://doi.org/10.19080/CTBEB.2017.03.555621

Alharbi WS, Almughem FA, Almehmady AM, Jarallah SJ, Alsharif WK, Alzahrani NM, et al. Phytosomes as an emerging nanotechnology platform for the topical delivery of bioactive phytochemicals. Pharmaceutics. 2021; 13(9):1475. https://doi.org/10.3390/pharmaceutics13091475 DOI: https://doi.org/10.3390/pharmaceutics13091475

Jain PK, Kharya M, Gajbhiye A. Pharmacological evaluation of mangiferin herbosomes for antioxidant and hepatoprotection potential against ethanol induced hepatic damage. Drug Development and Industrial Pharmacy. 2013; 39(11):1840-50. https://doi.org/10.3109/03639045.2 012.738685 DOI: https://doi.org/10.3109/03639045.2012.738685

Jain PK, Khurana N, Pounikar Y, Gajbhiye A, Kharya MD. Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system. Journal of liposome research. 2013; 23(2):110-8. https://doi.org/10.3109/08982104.2012.753456 DOI: https://doi.org/10.3109/08982104.2012.753456

Telange DR, Patil AT, Pethe AM, Fegade H, Anand S, Dave VS. Formulation and characterization of an apigeninphospholipid phytosome (APLC) for improved solubility, In vivo bioavailability, and antioxidant potential. European Journal of Pharmaceutical Sciences. 2017; 108:36-49. https://doi.org/10.1016/j.ejps.2016.12.009 DOI: https://doi.org/10.1016/j.ejps.2016.12.009

Anthrayose A, George N. Formulation and evaluation of phytosomal nanocarriers for enhanced chrysin delivery. World Journal of Pharmaceutical Research. 2018; 7(19):1026-41.

Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK. Curcumin-phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats. International Journal of Pharmaceutics. 2007; 330(1-2):155-63. https:// doi.org/10.1016/j.ijpharm.2006.09.025 DOI: https://doi.org/10.1016/j.ijpharm.2006.09.025

Freag MS, Elnaggar YS, Abdallah OY. Lyophilized phytosomal nanocarriers as platforms for enhanced diosmin delivery: optimization and ex vivo permeation. International journal of nanomedicine. 2013; 8:2385. https://doi.org/10.2147/IJN.S45231 DOI: https://doi.org/10.2147/IJN.S45231

Udapurkar PP, Bhusnure OG, Kamble SR. Diosmin Phytosomes: development, optimization and physicochemical characterization. Indian J Pharm Educ Res. 2018; 52:S29-S36.https://doi.org/10.5530/ijper.52.4s.73 DOI: https://doi.org/10.5530/ijper.52.4s.73

Li L, Liu Y, Xue Y, Zhu J, Wang X, Dong Y. Preparation of a ferulic acid-phospholipid complex to improve solubility, dissolution, and B16F10 cellular melanogenesis inhibition activity. Chemistry Central Journal. 2017; 11(1):1-8. https:// doi.org/10.1186/s13065-017-0254-8 DOI: https://doi.org/10.1186/s13065-017-0254-8

Pratap SR, Gangadharappa H, Mruthunjaya K. Formulation and Evaluation of Phytosome Loaded Drug Delivery of Gingerol for the treatment of respiratory infection. Journal of Innovation in Pharmaceutical Sciences. 2018; 2(2):1-6.

Kalita B, Patwary BN. Formulation and In vitro Evaluation of Hesperidin-Phospholipid Complex and its Antioxidant Potential. Current Drug Therapy. 2020; 15(1):28-36. https://doi.org/10.2174/1574885514666190226155933 DOI: https://doi.org/10.2174/1574885514666190226155933

Zhang K, Gu L, Chen J, Zhang Y, Jiang Y, Zhao L, et al. Preparation and evaluation of kaempferol-phospholipid complex for pharmacokinetics and bioavailability in SD rats. Journal of Pharmaceutical and Biomedical Analysis. 2015; 114:168-75. https://doi.org/10.1016/j.jpba.2015.05.017 DOI: https://doi.org/10.1016/j.jpba.2015.05.017

Telange DR, Patil AT, Pethe AM, Tatode AA, Anand S, Dave VS. Kaempferol-phospholipid complex: formulation, and evaluation of improved solubility, In vivo bioavailability, and antioxidant potential of kaempferol. Journal of Excipients and Food Chemicals. 2016; 7(4):1174.

Singh RP, Narke R. Preparation and evaluation of phytosome of lawsone. International Journal of Pharmaceutical Sciences and Research (IJPSR). 2015; 6(12):5217-26.

Hindarto CK, Surini S, Saputri FC, Irawan C. In vivo evaluation of luteolin-loaded phytosome. J Pharm Innov. 2017; 6:347-9.

Sabzichi M, Hamishehkar H, Ramezani F, Sharifi S, Tabasinezhad M, Pirouzpanah M, et al. Luteolinloaded phytosomes sensitize human breast carcinoma MDA-MB 231 cells to doxorubicin by suppressing Nrf2 mediated signalling. Asian Pacific Journal of Cancer Prevention. 2014; 15(13):5311-6.https://doi.org/10.7314/ APJCP.2014.15.13.5311 DOI: https://doi.org/10.7314/APJCP.2014.15.13.5311

Sikarwar MS, Sharma S, Jain AK, Parial S. Preparation, characterization and evaluation of marsupsin-phospholipid complex. Aaps Pharmscitech. 2008; 9(1):129-37. https:// doi.org/10.1208/s12249-007-9020-x DOI: https://doi.org/10.1208/s12249-007-9020-x

Manral K, Singh AK, Sah V. Development and characterization of morin loaded phytosomes for its anti-oxidant activity. Journal of Drug Delivery and Therapeutics. 2019; 9(4):30-6. DOI: https://doi.org/10.22270/jddt.v9i4-A.3420

Li Y, Yang D-J, Chen S-L, Chen S-B, Chan AS-C. Comparative physicochemical characterization of phospholipids complex of puerarin formulated by conventional and supercritical methods. Pharmaceutical research. 2008; 25(3):563-77. https://doi.org/10.1007/s11095-007-9418-x DOI: https://doi.org/10.1007/s11095-007-9418-x

Rasaee S, Ghanbarzadeh S, Mohammadi M, Hamishehkar H. Nano phytosomes of quercetin: A promising formulation for fortification of food products with antioxidants. Pharmaceutical sciences. 2014; 20(3):96-101.

Kalita B, Das MK, Sarma M, Deka A. Sustained anti-inflammatory effect of resveratrol-phospholipid complex embedded polymeric patch. Aaps Pharmscitech. 2017; 18(3):629-45. https://doi.org/10.1208/s12249-016-0542-y DOI: https://doi.org/10.1208/s12249-016-0542-y

Huang J, Chen PX, Rogers MA, Wettig SD. Investigating the phospholipid effect on the bioaccessibility of rosmarinic acid-phospholipid complex through a dynamic gastrointestinal In vitro model. Pharmaceutics. 2019; 11(4):156. https://doi.org/10.3390/pharmaceutics11040156 DOI: https://doi.org/10.3390/pharmaceutics11040156

Hooresfand Z, Ghanbarzadeh S, Hamishehkar H. Preparation and characterization of rutin-loaded nanophytosomes. Pharmaceutical Sciences. 2015; 21(3):145-51. https://doi.org/10.15171/PS.2015.29 DOI: https://doi.org/10.15171/PS.2015.29

Maryana W, Rachmawati H, Mudhakir D. Formation of phytosome containing silymarin using thin layer-hydration technique aimed for oral delivery. Materials today: proceedings. 2016; 3(3):855-66.https://doi.org/10.1016/j. matpr.2016.02.019 DOI: https://doi.org/10.1016/j.matpr.2016.02.019

Ittadwar PA, Puranik PK. Novel umbelliferone phytosomes: development and optimization using experimental design approach and evaluation of photo-protective and antioxidant activity. Int J Pharm Pharm Sci. 2017; 9:218-28. https://doi.org/10.22159/ijpps.2017v9i1.14635 DOI: https://doi.org/10.22159/ijpps.2017v9i1.14635

Telange DR, Nirgulkar SB, Umekar MJ, Patil AT, Pethe AM, Bali NR. Enhanced transdermal permeation and antiinflammatory potential of phospholipids complex-loaded matrix film of umbelliferone: Formulation development, physico-chemical and functional characterization. European Journal of Pharmaceutical Sciences. 2019; 131:23-38. https://doi.org/10.1016/j.ejps.2019.02.006 DOI: https://doi.org/10.1016/j.ejps.2019.02.006

Biswas S, Mukherjee PK, Harwansh RK, Bannerjee S, Bhattacharjee P. Enhanced bioavailability and hepatoprotectivity of optimized ursolic acid-phospholipid complex. Drug development and industrial pharmacy. 2019; 45(6):946-58. https://doi.org/10.1080/03639045.2019.1583755 DOI: https://doi.org/10.1080/03639045.2019.1583755

Upadhyay K, Gupta NK, Dixit VK. Development and characterization of phyto-vesicles of wedelolactone for hepatoprotective activity. Drug Development and Industrial Pharmacy. 2012; 38(9):1152-8. https://doi.org/10.3109/03639045.2011.643892 DOI: https://doi.org/10.3109/03639045.2011.643892

Sahu A. Development and characterization of hepatoprotective phytosomes of Abutilon indicum and Piper longum. International Journal of Pharmacy and Biological Sciences. 2015; 5(4):97-106.

Rathee S, Kamboj A. Optimization and development of antidiabetic phytosomes by the Box-Behnken design. Journal of Liposome Research. 2018; 28(2):161-72. https://doi.org/10.1080/08982104.2017.1311913 DOI: https://doi.org/10.1080/08982104.2017.1311913

Habbu P, Madagundi S, Kulkarni R, Jadav S, Vanakudri R, Kulkarni V. Preparation and evaluation of Bacopaphospholipid complex for antiamnesic activity in rodents. Drug invention today. 2013; 5(1):13-21. https://doi.org/10.1016/j.dit.2013.02.004 DOI: https://doi.org/10.1016/j.dit.2013.02.004

Karole S, Gupta G. Preparation and evaluation of phytosomes containing ethanolic extract of leaves of Bombax ceiba for hepatoprotective activity. Evaluation. 2019; 6(2):1-5.

Dhase AS, Saboo SS. Preparation and evaluation of phytosomes containing methanolic extract of leaves of Aegle marmelos (bael). International Journal of PharmTech Research. 2015; 8(6):231-40.

Ferrara T, De Vincentiis G, Di Pierro F. Functional study on Boswellia phytosome as complementary intervention in asthmatic patients. Eur Rev Med Pharmacol Sci. 2015; 19(19):3757-62.

Sahu AR, Bothara SB. Formulation and evaluation of phytosome drug delivery system of Boswellia serrata extract. Int J Res Med. 2015; 4(2):94-9.

Anwar E, Farhana N. Formulation and evaluation of phytosome-loaded maltodextrin-gum Arabic microsphere system for delivery of Camellia sinensis extract. Journal of young pharmacists. 2018; 10(2s):S56. https://doi.org/10.5530/jyp.2018.2s.11 DOI: https://doi.org/10.5530/jyp.2018.2s.11

Amudha S, Manna PK, Jeganathan N. Formulation and evaluation of capsules of Syzygium cumini phytosomes. J Pharm Sci Innov. 2018; 7(3).https://doi.org/10.7897/2277- 4572.07384 DOI: https://doi.org/10.7897/2277-4572.07384

Ho PJ, Sung JJ, Cheon KK, Tae HJ. Anti-inflammatory effect of Centella asiatica phytosome in a mouse model of phthalic anhydride-induced atopic dermatitis. Phytomedicine. 2018; 43:110-9.https://doi.org/10.1016/j.phymed.2018.04.013 DOI: https://doi.org/10.1016/j.phymed.2018.04.013

Udapurkar PP, Bhusnure OG, Kamble SR. Development and Characterization of Citrus Limon-phospholipid Complex as an Effective Phytoconstituent Delivery System. International Journal of Life Science & Pharma Research. 2018; 8.

Direito R, Reis C, Roque L, Gonçalves M, Sanches-Silva A, Gaspar MM, et al. Phytosomes with persimmon (Diospyros kaki l.) extract: Preparation and preliminary demonstration of In vivo tolerability. Pharmaceutics. 2019; 11(6):296. https://doi.org/10.3390/pharmaceutics11060296 DOI: https://doi.org/10.3390/pharmaceutics11060296

Panda VS, Naik SR. Cardioprotective effect of a chronic treatment of Ginkgo biloba Phytosomes in isoproterenol- induced cardiac necrosis in rats: Involvement of antioxidant system. J Phytopharmacol. 2014; 3:222-3. https://doi.org/10.31254/phyto.2014.3401 DOI: https://doi.org/10.31254/phyto.2014.3401

El-Menshawe SF, Ali AA, Rabeh MA, Khalil NM. Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product. International Journal of Nanomedicine. 2018; 13:307. https://doi.org/10.2147/IJN.S153429 DOI: https://doi.org/10.2147/IJN.S153429

Damle M, Mallya R. Development and evaluation of a novel delivery system containing phytophospholipid complex for skin aging. AAPS PharmSciTech. 2016; 17(3):607-17. https://doi.org/10.1208/s12249-015-0386-x DOI: https://doi.org/10.1208/s12249-015-0386-x

Arora S, Sharma A, Kaur P. Preparation and characterization of phytosomal-phospholipid complex of P. amarus and its tablet formulation. Journal of Pharmaceutical Technology, Research and Management. 2013; 1(1):1-18. https://doi.org/10.15415/jptrm.2013.11001 DOI: https://doi.org/10.15415/jptrm.2013.11001

Shalini S, Kumar RR, Birendra S. Terminalia arjuna bark on Human Breast Cancer Cell Lines (MCF-7). Int J Drug Dev & Res. 2015; 7(1):0975-9344.

Varma K, Vishwakarma G, Pathak R. Extraction phytochemical screening and development of phytosomes of hydroalcoholic extract of Terminalia chebula Retz for hepetoprotection. Journal of Drug Delivery and Therapeutics. 2019; 9(3):397-406.

El-Gazayerly O, Makhlouf A, Soelm A, Mohmoud M. Antioxidant and hepatoprotective effects of silymarin phytosomes compared to milk thistle extract in CCl4 induced hepatotoxicity in rats. Journal of Microencapsulation. 2014; 31(1):23-30. https://doi.org/10.3109/02652048.2013.8058 36 DOI: https://doi.org/10.3109/02652048.2013.805836

Sasongko RE, Surini S, Saputri FC. Formulation and characterization of bitter melon extract (Momordica charantia) loaded phytosomes. Pharmacognosy Journal. 2019; 11(6). https://doi.org/10.5530/pj.2019.11.192 DOI: https://doi.org/10.5530/pj.2019.11.192

Pereira A, Mallya R. Formulation and evaluation of a photoprotectant cream containing Phyllanthus emblica extract-phospholipid complex. Journal of Pharmacognosy and Phytochemistry. 2015; 4(2).

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