Journal of Natural Remedies

S. Selvi , P. Umadevi , D. Devipriya , P. Chinnaswamy

Abstract

The ethanolic extract of Calocybe indica was studied for its free radical scavenging property on different in vitro models like 1, 1 - diphenyl-picryl hydrazyl (DPPH) Assay, Ferric Reducing Antioxidant Power (FRAP) assay and in vitro antilipidperoxidative assay using goat liver homogenate and RBC Ghost model. The in vitro Lipid peroxidation (LPO) was inhibited to a good extent by the Calocybe indica ethanolic extract and the extent of inhibition being higher in the RBC membrane model than the liver homogenate model. The mushroom extract showed good dosedependent free radical scavenging property in both the models.

Keywords

Free Radical Scavenging, Calocybe indica, Antioxidant

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K. Jeyaprakash , P. Chinnaswamy

Abstract

Objective: The present study was carried out to evaluate the antioxidant property of spirulina and Liv-52 against lead induced toxicity in albino rats. Materials and methods: The antioxidant property of spirulina and Liv-52 was investigated by using lead acetate to induce toxicity in albino rats. The extent of lipid peroxidaiton in terms of thiobarbituric acid reactive susbstances (TBARS), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and reduced glutathine (GSH) were assayed in the liver and kidney homogenate. Results: Oral administration of lead (10mg/kg body weight/day) as lead acetate for 30 days resulted in a significant increase (P<0.01) in the level thiobarbituric acid reactive substances (TBARS) and a decrease in the level of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) when compared to normal control. Administration of both spirulina and Liv-52 produced a pronounced protective effect (P< 0.01) in respect to these parameters when compared to their individual administration in lead intoxicated rats. Conclusion: The results of the present study suggested the antioxidant and protective efficacy of spirulina and Liv-52 against lead induced toxicity in albino rats.

Keywords

Thiobarbituric Acid Reactive Substances (TBARS), Lead Intoxicated Rats, Protective Efficacy

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