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Jubie, S.
- Effect of Leaf Galls of Piper nigrum Linn. Against Carageenan Induced Inflammation in Albino Rats
Abstract Views :478 |
PDF Views:507
Authors
Source
Journal of Natural Remedies, Vol 7, No 2 (2007), Pagination: 229-233Abstract
Objective: To evaluate the anti-inflammatory activity of leaf galls of Piper nigrum Linn. against the carageenan induced paw oedema in Albino rats. Materials and methods: The benzene, chloroform and ethanol extracts of leaf galls of Piper nigrum Linn. were obtained by continuous soxhlet extraction. Each extract was assessed for anti-inflammatory activity in carageenan induced Albino rats by measuring the paw volume and ulcerogenic activity was also carried out. Results: All the extracts showed significant (P<0.05) anti-inflammatory activity in which ethanol extract showed prominent (P<0.01) effect. The extracts were devoid of ulcerogenic action. Conclusion: From the results, it is revealed that, the active ethanol extract of leaf galls of Piper nigrum is worthwhile to develop the bioactive principle for inflammatory disorders.Keywords
Piper nigrum, Antiinflammatory, UlcerogenicFull Text
- Discovery of Immunomodulators from Plant Kingdom Targeting IL-6 for the Effective Management Therapy of SARS-CoV-2
Abstract Views :163 |
PDF Views:92
Authors
Akey Krishna Swaroop
1,
Palathoti Nagarjuna
1,
P. Naresh
1,
P. Shyam Sundar
1,
S. Jubie
1,
Jawahar Natarajan
2,
P. Vasanth
3
Affiliations
1 Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, The Nilgiris – 643001, Tamil Nadu, IN
2 Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, The Nilgiris – 643001, Tamil Nadu, IN
3 Department of Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, The Nilgiris – 643001, Tamil Nadu, IN
1 Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, The Nilgiris – 643001, Tamil Nadu, IN
2 Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, The Nilgiris – 643001, Tamil Nadu, IN
3 Department of Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, The Nilgiris – 643001, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 22, No 2 (2022), Pagination: 249 - 260Abstract
The present study was conducted because of the recent scenario of this pandemic coronavirus outbreak worldwide. Currently, this disease cannot be treated through specific vaccines and therapeutic medicines. While many vaccines are being investigated, it would take some time for these to be accessible to the masses. Eventual evidence indicates that many COVID-19 patients may die from an irregular release of cytokines called as Cytokine Release Syndrome (CRS) due to the excessive reaction of their immune systems. In worsening patients with COVID-19, CRS played a significant role, from pneumonia via ARDS to cumulative systemic inflammation and eventually to a failing of the multi-system organ. In COVID-19 individuals, a large number of cytokines, including IL-6, IL-1, IL-2, IL-10, TNF- α, and IFN- α, participate in the ‘cytokine storm,’ but IL-6, whose higher serum levels are associated with respiratory failure, ARDS, and adverse clinical outcomes, tends to be a critical factor. In China, the COVID-19 mortality indicator has been tested by a multi-centre retrospective analysis in 150 COVID-19 patients. The study analysed that 82 cases are resolved from COVID-19 and 68 cases are dead due to enhancement of IL-6 levels in the serum. In this research, the secondary plant metabolites from Indian traditional medicine are identified through a computational technique and the selected seedling metabolite is sealed to block the IL-6 receptor.Keywords
Covid-19, IL-6, Cytokine Release Syndrome, Secondary MetabolitesFull Text
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