Medico-Legal Update

Azal H. Jumaa ¹, Ahmed Sami Jarad ², Wissam Sajid Hashim Al Uboody ³

Affiliations
1 AL-Yarmouk University College, Department Of Dentistry, Baghdad, IQ
2 College of Veterinary Medicine, University of Fallujah, IQ
3 Department of physiology, College of medicine, Al Muthanna University, IQ

Abstract

Esomeprazole is an inhibitor of the proton pump that reduces gastric acidity and is used in indigestion treatment; Esomeprazole is a promising treatment for tumors, such as melanoma and B cell leukemia, through several mechanisms, including rapid cellular acidification and activation of many types of caspase enzymes, which in turn lead to the activation of cellular apoptosis This work was designed to assess the toxicity of the (Esomeprazole) on (HeLa cell line) in vitro at concentrations starting from one - ten thousand μg/ milliliter and compared with cytotoxicity of vincristine and methotrexate at concentrations between one - ten thousand μg/ milliliter In 3 incubation periods The results showed that the cellular toxicity of one μg / milliliter was a lot of more than the cellular toxicity of ten and a hundred μg / milliliter. The results additionally showed that toxicity of esomeprazole was considerably more than vincristine and methotrexate on HLA cells at seventy two hours.

Keywords

esomeprazole, vincristine, Hela cancer cell line

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