Research Journal of Pharmacy and Technology

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2, 3-Disubstituted Quinazolinones:Study of its Anti-Microbial Activity


Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-605 006, India
2 Jawaharlal Nehru Technological University, Ananthapur, India
     

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A series of some novel 2, 3-disubstituted quinazolinone derivatives were synthesized by condensing 2-methyl benzoxazine with various amino acids and further reacted with aromatic aldehyde to yield the title compounds. The structures of the synthesized compounds were confirmed by melting point, Thin Layer Chromatography, IR, H1-NMR, Mass and Elemental Analysis. Lipinski's rule of five and Druglikeness properties were evaluated using molinspiration software. Docking study of the synthesized compound were carried out by Auto Dock software using Dihydofolate Reductase Inhibitor as a target enzyme. Synthesized derivatives were screened for their anti-bacterial and anti-fungal activities.

Keywords

Quinazolinone, Amino Acids, Aromatic Aldehyde, Dihydrofolate Reductase, Anti-Bacterial, Anti-Fungal Activity.
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  • 2, 3-Disubstituted Quinazolinones:Study of its Anti-Microbial Activity

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Authors

K. Girija
Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-605 006, India
S. Sathiyaraj
Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-605 006, India
V. Rajendiran
Jawaharlal Nehru Technological University, Ananthapur, India
K. Hemalatha
Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-605 006, India

Abstract


A series of some novel 2, 3-disubstituted quinazolinone derivatives were synthesized by condensing 2-methyl benzoxazine with various amino acids and further reacted with aromatic aldehyde to yield the title compounds. The structures of the synthesized compounds were confirmed by melting point, Thin Layer Chromatography, IR, H1-NMR, Mass and Elemental Analysis. Lipinski's rule of five and Druglikeness properties were evaluated using molinspiration software. Docking study of the synthesized compound were carried out by Auto Dock software using Dihydofolate Reductase Inhibitor as a target enzyme. Synthesized derivatives were screened for their anti-bacterial and anti-fungal activities.

Keywords


Quinazolinone, Amino Acids, Aromatic Aldehyde, Dihydrofolate Reductase, Anti-Bacterial, Anti-Fungal Activity.