Open Access
Subscription Access
Open Access
Subscription Access
Freeze Dried Fenugreek Seed Mucilage as Disintegrant for Fast Dissolving Tablets of Valsartan
Subscribe/Renew Journal
The objective of the research work was to formulate fast dissolving tablet of valsartan using freeze-dried fenugreek seed mucilage as disintegrant. An attempt was made to extract the mucilage from fenugreek seeds and Ocimum tenuiflorum linn seeds and was evaluated for its various physicochemical characteristics. Fast dissolving tablets of valsartan was formulated by direct compression using different concentrations of fenugreek gum and Ocimum tenuiflorum gum as a natural superdisintegrants and compared with synthetic superdisintegrants like crospovidone. The tablets formulated using fenugreek gum and Ocimum tenuiflorum were evaluated for various physical tests like friability, weight variation, hardness. In vitro dissolution study showed 93.32% and 91.46% drug release, 42, and 53 seconds disintegration time, respectively for fenugreek and Ocimum tenuiflorum gum tablets. Natural gums like fenugreek and Ocimum tenuiflorum have better disintegration properties with improved disintegration time, when used in combination with synthetic disintegrants.
Keywords
Fast Dissolving Tablet, Valsartan, Freeze-Dried Natural Disintegrants.
Subscription
Login to verify subscription
User
Font Size
Information
- Siddhiqui NM, Gorg G, Sharma PK. Fast dissolving tablet: preparation, characterization and evaluation: an overview. International Journal of Pharmaceutical Sciences Review and Research. 2010; 4:87-96.
- Bala R, Khanna S, Pawar P. Polymers in fast disintegrating tablets – a review. Asian Journal of Pharmaceutical and Clinical Research.2012; 5: 8-14.
- Karthikeyan M, Umarul MAK, Megha M, Shadeer HP. Formulation of diclofenac tablets for rapid pain relief. Asian Pacific Journal of Tropical Biomedicine. 2011; 2(1): S308–S311.
- Kumar S, Gupta SK, Sharma PK. A review on recent trends in oral drug delivery-fast dissolving formulation technology. Advances in Biological Research. 2012; 6(1): 6-13.
- Puttewar TY, Kshirsagar MD, Chandewar AV, Chikhale RV. Formulation and evaluation of orodispersible tablet of taste masked doxylamine succinate using ion exchange resin. Journal of King Saud University - Science. 2010; 22(4): 229-240.
- Vaghela BJ. Formulation and evaluation of fast disintegrating tablets of diclofenac sodium. International Journal of Pharmaceutical Research and Development. 2011; 3(6): 17-22.
- Revathi S, Moulali SK, Dhanaraju MD. Formulation and evaluation of orodispersible valsartan tablets. Der Pharmacia Lettre. 2015;7 (1): 315-324.
- Rabab AH, Amr SAL, Marwa HA, Hanaa AE. Fast disintegrating tablet of Valsartan for the treatment of pediatric hypertension: In vitro and in vivo evaluation. Journal of Drug Delivery Science and Technology. 2018; 43: 194-200.
- Kumar MU, Babu MK. Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant. Asian Pac J Trop Biomed. 2014; 4(1):S329-S334.
- Kamble MS, Mendake SD, Aute PP, Mane SS, Borwandkar VG, Mane OR, Chaudhari, PD. Pharmaceutical Characterization of ocimum tenuiflorum Linn. Seed mucilage as superdisintegrant. International Journal of Pharmaceutical and Chemical Sciences. 2012; 1(4): 1985-1990.
- Shaha V, Patel R. Studies on Mucilage from Hibuscus Rosa- Sinensis Linn as Oral Disintegrant. International Journal of Applied Pharmaceutics. 2010; 2(1):18-21.
- Sukhavasi S, Sai KV. Formulation and evaluation of fast dissolving tablets of Amlodipine besylate by using fenugreek seed mucilage and ocimum basilicum gum. International Current Pharmaceutical Journal. 2012; 1 (9): 243-249.
- Verma S, Bansal J, Kumar N, Malviya R, Sharma PK. Isolation and characterization studies of mucilage obtained from trigonella foenum greacum L. Seed and tamarindus indica polysachharide as pharmaceutical excipients. Journal of Drug Delivery and Therapeutics. 2014; 4(3):106-109.
- Malviya R, Srivastava P, Bansali M. Preparation and evaluation of disintegrating properties of cucurbita maxima pulp powder. International Journal of Pharm Sciences. 2010; 2(1): 395-399.
- Kavitha K, Subramaniam K, Santhi K, Boey JH, Dhanaraj SA, Kumar R. Potential drug candidates for fast dissolving drug delivery - a review. Research Journal of Pharmaceutical Bio and Chemical Sciences. 2010; 4:1510-1526.
- Kamble MS, Mendake SD, Aute PP, Chaudhari PD. Studies on isolation and evaluation of ocimum tenuiflorum linn seed mucilage. Journal of Drug Delivery and Therapeutics. 2012; 2(6): 25-28.
- Abdolhossein M, Maryam T. Quince Seeds Biopolymer: Extraction, Drying Methods and Evaluation. Jundishapur Journal of Natural Pharmaceutical Products. 2015; 10(3): e25392.
- Allen LV, Popovich NG, Ansel HC. Solid dosage forms and solid modified release drug delivery system. In Ansel’s pharmaceutical dosage forms and drug delivery system, Edited by Troy DB. Lippincott Williams & Wilkins, USA. 2011; 9th ed.: p. 233.
- Jani GK, Shah DP. Evaluation of mucilage of Hibiscus rosasinensis Linn as rate controlling matrix for sustained release of diclofenac. Drug Development and Industrial Pharmacy. 2008; 34(8): 807-816.
- Rangole US, Kawtikwar PS, Sakarkar DM. Formulation and in vitro evaluation of rapidly disintegrating tablets using hydrochlorothiazide as a model drug. Research Journal of Pharmacy and Technology. 2008; 1(4): 349-352.
- Dave V, Yadav RB, Ahuja R, Yadav S. Formulation design and optimization of novel fast dissolving tablet of chlorpheniramine maleate by using lyophilization techniques. Bulletin of Faculty of Pharmacy, Cairo University. 2017; 55: 31–39.
- Jain H, Pasha T, Bais C, Bhandari A. Formulation and characterization of liquisolid tablets of valsartan for improvement of dissolution rate. Asian Journal of Pharmaceutical and Clinical Research. 2014 ; 7(4): 21-26.
- Patel DM, Patel SP, Patel CN. Formulation and evaluation of fast dissolving tablet containing domperidone ternary solid dispersion. International journal of pharmaceutical investigation. 2014; 4(4): 174–182.
Abstract Views: 251
PDF Views: 0