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Development and Validation of Analytical Method for Estimation of Cetirizine Hydrochloride and Phenylephrine Hydrochloride in Pharmaceutical Formulation
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Analytical method using Fourier transform Infrared Spectroscopy was developed and validated for estimation of cetirizine hydrochloride and phenylephrine hydrochloride in their pharmaceutical formulation. The solid-state samples were prepared by dilution in dry potassium bromide and were analyzed by FTIR Spectrophotometer. A linear relationship for the carbonyl peak area centered around 1741cm-1 was observed in the range of 0.2-1.2% w/w with good correlation coefficient 0.997 for the cetirizine hydrochloride and for the hydroxyl peak area centered around 3419 cm-1 was observed in the range of 0.4-2.4% w/w with good correlation coefficient 0.998 for phenylephrine hydrochloride. The developed method was validated as per ICH guidelines.In addition to this the stability study is carried out by thermal exposure, photolytic exposure and sunlight exposure.
Keywords
Cetirizine Hydrochloride, Phenylephrine Hydrochloride, FT-IR, Method Validation and ICH Guideline.
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- Pavia DL, Lampman GM and Kriz GS. Introduction to spectroscopy. 2001; 3rd ed: pp 13-24.
- https://en.wikipedia.org/wiki/Cetirizine.
- Indian Pharmacopoeia Government of India, Ministry of Health and Family Welfare, published by controller of publication, Delhi2007; Vol-II, 267-268.
- Indian Pharmacopoeia Government of India, Ministry of Health and Family Welfare, published by controller of publication, Delhi2007; Vol-III, 143-144.
- Wankhede SB, Lad KA and Chitlange SS. Development and Validation of UV-Spectrophotometric Methods for Simultaneous Estimation of Cetirizine hydrochloride and Phenylephrine hydrochloride in Tablets. International Journal of Pharmaceutical Sciences and Drug Research. 4(3); July-September 2012: 222-226.
- Jaybhaye SS et al. Development and validation of UV Spectrophotometric assay protocol for simultaneous estimation of Paracetamol, Phenylephrine, Cetirizine in combine tablet dosage form using simultaneous equation by matrix method. International Journal Of Drug Formulation And Research. 4(2); Mar-Apr 2013.
- Merukar SS et al. Simultaneous spectrophotometric methods for Estimation of Levocetirizine and Pseudoephedrine in Pharmaceutical tablet dosage form. Journal of Pharmaceutical Sciences and Research, 1(2); 2009: 38-42.
- Sharma D et al. Development and Validation Of Spectroscopic Method For Simultaneous Estimation of Salbutamol Sulphate, Ambroxol Hydrochloride And Cetirizine Hydrochloride In Combined Pharmaceutical Tablet Formulation: A Novel Technique For In - Vitro Dissolution Studies. International Journal of Pharmacy and Pharmaceutical Sciences. 6(11); 2014: 446 – 452.
- Patel MK and Veni KJK. Analytical Method Development and Validation of Cetirizine Hydrochloride and Phenylephrine Hydrochloride in Combined Dosage Form. Journal of Pharmaceutical Sciences and Bioscientific Research. 5 (2); 2015: 180-186.
- Wadher SJ, Kalyankar TM and Panchal PP. Development and Validation of Simultaneous Estimation of Chlorpheniramine Maleate and Phenylephrine Hydrochloride in Bulk and Capsule Dosage Form by Ultra-Violet Spectrophotometry. International Journal of Chem Tech Research. 5(5); July-Sept 2013: 2410-2419.
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