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DNA Binding And Antimicrobial Activity of Cobalt (III) Complex Containing 2,2’ Bipyridyl and 8-Hydroxy Quinoline as Ligands


Affiliations
1 Department of Chemistry, Thiruvalluvar University, Vellore – 632115. Tamilnadu, India
2 Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam - 638401. Tamilnadu, India
     

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In this paper cobalt complex of type [Co(Bipy)2(8HQ)](ClO4)2 [Bipy = 2,2’-bipyridyl, HQ = 8-Hydroxy Quinoline) has been synthesized and characterized by elemental analyses, NMR, UV-visible, infrared spectral studies. DNA binding properties of this metal complex was investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and cyclic voltammetry. The experimental results indicate that the complex bind to DNA through an intercalative mode. The complex tested for biological activity and it has good antibacterial and antifungal activity on comparing with standard drugs.

Keywords

DNA Binding, Cobalt(III) Complex, Antimicrobial Activity, 8-Hydroxy Quinoline.
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  • Gottesfeld JM, Neely L, Trauger JW, Baird EE, Dervan PB. Regulation of gene expression by small molecules. Nature. 387, 1997, 202–205.

  • Zhang XQ, Xu X Bertrand N, Pridgen E, Swami A, Farokhzad OC. Interactions of nanomaterials and biological systems: implications to personalized nanomedicine. Advanced Drug Delivery Reviews. 64, 2012, 1363-1384.

  • Baskaran S, Murali Krishnan M, Arumugham MN. Synthesis, crystal structure, DNA binding, cleavage and cytotxicity, antimicrobial activity of new copper(II) complex with L-ornithine and 1,10-phenanthroline. Inorganic and Nano-Metal Chemistry. 47, 2017, 269-277.

  • Saravanan PC, Murali Krishnan M, Arumugham MN. DNA Binding and Biological Activities of Ternary Copper(II) Complexes Containing L-valine and Urea. Indian Journal of Advances Chemical Science. 5, 2017, 1-6.

  • Navarro M, Cisneros-Fajardo EJ, Sierralta A, Fernández-Mestre M, Silva P, Arrieche D, Marchán E. Design of copper DNA intercalators with leishmanicidal activity. Journal of Biological Inorganic Chemistry. 8, 2003, 401-408.

  • Metcalfe C, Thomas JA. Kinetically inert transition metal complexes that reversibly bind to DNA. Chemical Society Reviews. 32, 2003, 215-224.

  • Silvestri A, Barone G, Ruisi G, Teresa Lo Giudice M, Tumminello S. The interaction of native DNA with iron(III)-N,N’-ethylene-bis(salicylideneiminato)-chloride. Journal of Inorganic Biochemistry. 98, 2004, 589-594.

  • Zeng YB, Yang N, Sheng Liu W, Tang N. Synthesis, characterization and DNA-binding properties of La(III) complex of chrysin. Journal of Inorganic Biochemistry. 97, 2003, 258-264.

  • Mahadevan S, Palaniandavar M. Spectroscopic and voltammetric studies of copper(II) complexes of bis(pyrid-2-yl)-di/trithia ligands bound to calf thymus DNA. Inorganica Chimica Acta. 254, 1997, 291-302.

  • Fraser RSS, Creanor J. Rapid and Selective Inhibitionof RNA Synthesis in Yeast by 8-Hydroxyquinoline. European Journal of Biochemistry. 46, 1974, 67-73.

  • Coyle B, Kavanagh K, McCann M, Devereux M, Geraghty M. Mode of anti-fungal activity of 1,10-phenanthroline and its Cu(II), Mn(II) and Ag(I) complexes. Biometals. 16, 2003, 321-329.

  • Baskaran S, Murali Krishnan M, Arumugham MN, Rakesh Kumar. Synthesis and DNA studies of a copper(II) complex of 5,6-dihydro-5,6-epoxy-1,10-phenanthroline. Journal of Coordination Chemistry. 68, 2015, 4395-4407.

  • Baskaran S, Murali Krishnan M, Arumugham MN, Rakesh Kumar. DFT analysis and DNA binding, cleavage of copper(II) complexes. Journal of Molecular Liquids. 221, 2016, 1045-1053.

  • Kaim W. Rall J. Copper – A Modern Bioelement. Angewandte Chemie International Edition, 35, 1996, 43-60.

  • Dhakshanamoorthy S, Murali Krishnan M, Arumugham MN. Synthesis, Characterisation, DNA Binding/Cleavage, Anticancer and Antimicrobial Activity of Ternary Copper(II) Complexes. Asian Journal of Research in Chemistry. 10, 2017, 312-318.

  • Ezhilarasan D, Murali Krishnan M, Arumugham MN. DNA Binding / Cleavage and Antimicrobial Activity of Copper(II) Complexes Containing L-methionine and Urea. Journal of Chemistry and Chemical Sciences. 7, 2017, 477-485.

  • Dhakshanamoorthy S, Murali Krishnan M, Arumugham MN. DNA Binding/Cleavage Studies of Copper(II) Complexes Containing Heterocyclic Bases, L-Serine and Semicarbazide. International Journal of Chemical and Physical Sciences. 6, 2017, 39-47.

  • Sivakumar K, Komathi V, Murali Krishnan M. Dinitrophenylhydrazine: β-cyclodextrin inclusion complex as a novel fluorescent chemosensor probe for Ce4+. Research on Chemical Intermediates. 2018, 1-27, https://doi.org/10.1007/s1116.

  • Sivakumar K. Parinamachivayam G, Murali Krishnan M, Chakravarty C, Bharathi A. Preparation, characterization and molecular modeling studies of the beta-cyclodextrin inclusion complex with benzoguanamine and its analytical application as chemosensor for the selective sensing of Ce4+. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 200, 2018, 212-225.

  • Li J, Dong J, Cui H, Xu T, Li L. A copper(II) complex of the Schiff base from L-valine and 2-hydroxy-1- naphthalidene plus 1,10-phenanthroline: synthesis, crystal structure and DNA interaction. Transition Metal Chemistry. 37, 2012, 175-182.

  • Gopinathan H, Komathi N, Arumugham MN. Synthesis, structure, DNA binding, cleavage and biological activity of cobalt (III) complexes derived from triethylenetetramine and 1,10 phenanthroline ligands. Inorganica Chimica Acta. 416, 2014, 93-101.

  • Chen YQ. Synthesis, characterization, bioactivities of copper complexes with N-allyl di(picolyl)amine. Spectrochimica Acta A: Molecular Biomolecular Spectroscopy. 75, 2010, 355-360.

  • Grueso E, López-Pérez G, Castellano M, Prado-Gotor R. Thermodynamic and structural study of phenanthroline derivative ruthenium complex/DNA interactions: Probing partial intercalation and binding properties. Journal of Inorganic Biochemistry. 106, 2012, 1-9.

  • Lakowicz JR, Webber G. Quenching of fluorescence by oxygen. A probe for structural fluctuations in macromolecules. Biochemistry. 12, 1973, 4161.

  • Satyanarayana S, Dabrowiak JC, Chaires JB. Neither .DELTA.- nor .LAMBDA.-tris(phenanthroline)ruthenium(II) binds to DNA by classical intercalation. Biochemistry. 31, 1992, 9319.

  • Haq I, Lincoln P, Suh D, Norden B, Chowdhry BZ, Chaires JB. Interaction of DELTA.- and LAMBDA [Ru(phen)2DPPZ]2+ with DNA: A Calorimetric and Equilibrium Binding Study. Journal of American Chemical Society. 17, 1995, 4788.

  • Carter M, Rodriguez M, Bar AJ. Voltammetric studies of the interaction of metal chelates with DNA. Tris-chelated Complexes of cobalt (III) and iron (II) with 1,10-phenanthroline and 2,2'-bipyridine. Journal of American Chemical Society. 111, 1989, 8901.

  • Santhakumar P, Arumugham MN. Synthesis, characterization of copper (II) complex with mixed ligands of 1,10-phenanthroline, L-phenylalanine and ethylamine: studies on DNA binding, nuclease and biological activities. International Journal of Recent Scientific Research. 3, 2012, 459-466.

  • Robertazzi A, Magistrato A, de Hood P, Carloni P, Reedijk J. Density Functional Theory Studies on Copper Phenanthroline Complexes. Inorganic Chemistry. 46, 2007, 5873-5881.

  • Dhakshanamoorthy, Murali Krishnan M, Arumugham MN. Ternary copper(II) complexes containing thiosemicarbazide: DNA binding, antimicrobial activities and DFT study. Indian Journal of Advances in Chemical Science. 6, 2018, 53-58.

  • Murali Krishnan M, Baskaran S, Arumugham MN. Photochemical and DFT/TD-DFT study of trifluoroethoxy substituted asymmetric metal-free and copper(II) phthalocyanines. Journal of Fluorine Chemistry. 202, 2017, 1-8.


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  • DNA Binding And Antimicrobial Activity of Cobalt (III) Complex Containing 2,2’ Bipyridyl and 8-Hydroxy Quinoline as Ligands

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Authors

S. Dhakshanamoorthy
Department of Chemistry, Thiruvalluvar University, Vellore – 632115. Tamilnadu, India
N. Sri Gayathrai Devi
Department of Chemistry, Thiruvalluvar University, Vellore – 632115. Tamilnadu, India
M. Murali Krishnan
Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam - 638401. Tamilnadu, India
M. N. Arumugham
Department of Chemistry, Thiruvalluvar University, Vellore – 632115. Tamilnadu, India

Abstract


In this paper cobalt complex of type [Co(Bipy)2(8HQ)](ClO4)2 [Bipy = 2,2’-bipyridyl, HQ = 8-Hydroxy Quinoline) has been synthesized and characterized by elemental analyses, NMR, UV-visible, infrared spectral studies. DNA binding properties of this metal complex was investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and cyclic voltammetry. The experimental results indicate that the complex bind to DNA through an intercalative mode. The complex tested for biological activity and it has good antibacterial and antifungal activity on comparing with standard drugs.

Keywords


DNA Binding, Cobalt(III) Complex, Antimicrobial Activity, 8-Hydroxy Quinoline.

References