Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Fibromyalgia Syndrome and Acne Vulgaris:A New Link


Affiliations
1 Rheumatology Unit, Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq
2 Rheumatology Unit, Baghdad Teaching Hospital, Iraq
     

   Subscribe/Renew Journal


Objectives: The study aimed to assess the relationship between fibromyalgia syndrome and its related symptoms with acne vulgaris in a sample of Iraqi patients. Patient and method: One hundred acne patients and one hundred age- and sex-matched apparently healthy individuals were enrolled in the study. A special questionnaire designed for the purpose of the study was used for recording information from the patients and controls. The 2012 Canadian Guidelines for diagnosis of fibromyalgia were used to diagnose FMS among patients and controls and acne severity was assessed using Global Acne Grading System method. Results: This study showed that there was a three-folds increase in the risk of developing fibromyalgia syndrome among acne patients compared to normal individuals (12% vs. 4%). Moreover, widespread pain, cognitive disturbance and anxiety were significantly higher among acne patients compared to healthy individuals. It was found that there was a four times increase in the risk of having fibromyalgia syndrome with the increase in the duration of acne. In addition to that, widespread pain, anxiety and cognitive disturbance increase significantly with the increase in its duration. Conclusions: fibromyalgia syndrome was more common in acne patients and increase with the increase in acne duration.

Keywords

Fibromyalgia Syndrome, Acne Vulgaris, Diffuse Pain Syndrome and Acne Vulgaris, Fibromyalgia and Acne Vulgaris.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Garip Y, Güler T, Çifçi N, et al. Impact of fibromyalgia syndrome on quality of life in patients with Behçet’s disease. Turk J Phys Med Rehab 2016; 1(62):45-50.

  • Al- Rawi ZS, Gorial FI, Mahmood AS, et al. Fibromyalgia Syndrome among Iraqi Female Patients with Breast Cancer. Pan Arab Journal of Oncology 2013; 6(2):30-33.

  • Hawkins RA. Fibromyalgia: A Clinical Update. J Am Osteopath Assoc. 2013; 113(9):680-89.

  • Chen JL, McKenzieBrown AM. The Epidemiology and Prevalence of Fibromyalgia (FMS). In: Lawson E, Wallace MS. Fibromyalgia: clinical guidelines and treatments. Switzerland: Springer International Publishing 2015:1-21.

  • Fitzcharles MA, Ste-Marie PA, Goldenberg DL , et al. 2012 Canadian Guidelines for the diagnosis and management of fibromyalgia syndrome: Executive summary. Pain Res Manag 2013; 18(3):119-26.

  • Al-Rawi ZS, Kamil AH. Prevalence of FMS among school children and adolescents in Iraq. Arthritis Rheum 2000; 43: 2129. Arnold LM, James I. Hudson JI, Hess EV, et al. Family Study of Fibromyalgia. Arthritis and Rheumatism 2004; 50(3):944-52.

  • Jassim NA, Gorial FI, Asker BA, Najeeb AA, Al-Gibory SA. Fibromyalgia Syndrome in 104 Iraqi Patients with Inflammatory Bowel Disease. The I P M J 2011; 10(3):352-57.

  • Dymon TE. Fibromyalgia. In: Dong BJ, Elliott DP. Neurologic and Psychiatric Care. USA: ACCP 2015:5-18.

  • Al-Bidri KZM. Prevalence of Fibromyalgia in Iraqi People with Joint Hypermobility Syndrome. The I P M J 2008; 7(1):18-21.

  • Häuser W, Urrútia G, Tort S, et al. Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia syndrome. Cochrane Database Syst Rev. 2013:8.

  • Choy EHS. The Patient with Diffuse Pain. In: Imboden JB, Hellmann DB, Stone JH. Current Diagnosis and Treatment Rheumatology 3rd ed. New York. McGraw-Hill Education, LLC 2013:131-38.

  • Zaenglein AL, Thiboutot DM. Acne Vulgaris. In: Bolognia JL, Jorizzo JL, Schaffer JV. Dermatology 3rd ed. Elsevier Inc. 2012:545-60

  • Weller RB, Hunter HJA, Mann MW.Sebaceous and Sweat Gland Disorders. In: Weller RB, Hunter HJA, Mann MW. Clinical Dermatology 5th ed. UK: John Wiley and Sons Ltd 2015:156-70 14. Tan JKL, Bhate K. A Global perspective on the epidemiology of acne. BJD 2015; 172(1):3-12.

  • Duman H, Topal IO, Kocaturk E, Duman MA. Evaluation of anxiety, depression, and quality of life in patients with acne vulgaris, and quality of life in their families. D S 2016; 34(1):6-9.

  • Golchai J, Khani SH, Heidarzadeh A, et al. Comparison of anxiety and depression in patients with acne vulgaris and healthy individuals. I J D. 2010; 55(4): 352-54.

  • Al-Huzali SMA, Al-Malki KS, Al-Nikhali SAS, Al-Matrafi KAM. Prevalence of Depression Among Acne Patients in King Faisal Hospital and King Abulaziz Hospital in Makkah, Saudi Arabia. I J M S P H 2014; 3(9): 1150-56.

  • Misery L, Wolkenstein P, Amici JM, et al. Consequences of Acne on Stress, Fatigue, Sleep Disorders and Sexual Activity: A Population-based Study. A V 2015; 95:485-88.

  • Tan JKL. Current Measures for the Evaluation of Acne Severity. E R D. 2008; 3(5):595-603.

  • Lajevardi V, Ghodsi SZ, Daneshpazhooh M, et al. The relationship between body mass index and the severity of acne. I J D 2014; 17(1):13-17.

  • Yazmalar L, Çelepkolu T, Batmaz I, et al. High Frequency of Fibromyalgia in Patients with Acne Vulgaris. A R 2016; 31(2):170-75.

  • Öztürk A, Deveci̇ E, Bağcioğlu E, Atalay F, Serdar Z. Anxiety, depression, social phobia, and quality of life in Turkish patients with acne and their relationships with the severity of acne. T J M S 2013; 43:660-66.

  • Deveci E, Öztürk A, Kırpınar I, et al. Neurocognition in Patients with Acne Vulgaris. J P 2014; 17(4):1-7.

  • Zhang H, Liao W, Chao W, et al. Risk factors for sebaceous gland diseases and their relationship to gastrointestinal dysfunction in Han adolescents. J D. 2008; 35(9):555-61.

  • Sperling LC, Sinclair RD and Shabrawi-Caelen LE. Alopecias. In: Bolognia JL, Jorizzo JL, Schaffer JV. Dermatology 3rd ed. Elsevier Inc. 2012: 1093-114.

  • Branco JC, Bannwarth B, Failde I, et al. Prevalence of Fibromyalgia: A Survey in Five European Countries. S A R 2010; 39(6):448-53.

  • Walitt B, Nahin RL, Katz RS, Bergman MJ and Wolfe F. The Prevalence and Characteristics of Fibromyalgia in the 2012 National Health Interview Survey. PLoS One 2015; 10(9):1-16.

  • Lawrence RC, Felson DT, Helmick CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States, Part II. A R 2008; 58(1):26-35.

  • Munshed MH, Gorial FI and Al-Janabi AA. The Relationship between Fibromyalgia Syndrome and B ody Mass Index. J F M B 2010; 52(1):37-40.

  • Layton AM, Eady EA, Zouboulis CC. Acne. In: Griffiths CEM, Barker J, Bleiker T. Rook's Textbook of Dermatology 9th ed. UK: John Wiley and Sons, Ltd 2016:90:1-65.

  • Bowe WP and Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future? G P 2011; 3(1):1-11.

  • Goebel A, Buhner S, Schedel R, Lochs H and Sprotte G. Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome. Rheumatology (Oxford) 2008; 47(8):1223-27.

  • Kadim EJ, Daoud MS, Alosami MH. The Role of Interleukin-8 in Patients with Primary Fibromyalgia. I P M J 2011; 10(3):347-51.

  • Raison CL, Borisov AS, Woolwine BJ, et al. Interferon-α effects on diurnal hypothalamic–pituitary–adrenal axis activity: relationship with proinflammatory cytokines and behavior. M P. 2010; 15(5): 535–47.


Abstract Views: 220

PDF Views: 0




  • Fibromyalgia Syndrome and Acne Vulgaris:A New Link

Abstract Views: 220  |  PDF Views: 0

Authors

Mohammed Hadi Alosami
Rheumatology Unit, Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq
Faiq I. Gorial
Rheumatology Unit, Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq
Dalia Mohammed Jasim
Rheumatology Unit, Baghdad Teaching Hospital, Iraq

Abstract


Objectives: The study aimed to assess the relationship between fibromyalgia syndrome and its related symptoms with acne vulgaris in a sample of Iraqi patients. Patient and method: One hundred acne patients and one hundred age- and sex-matched apparently healthy individuals were enrolled in the study. A special questionnaire designed for the purpose of the study was used for recording information from the patients and controls. The 2012 Canadian Guidelines for diagnosis of fibromyalgia were used to diagnose FMS among patients and controls and acne severity was assessed using Global Acne Grading System method. Results: This study showed that there was a three-folds increase in the risk of developing fibromyalgia syndrome among acne patients compared to normal individuals (12% vs. 4%). Moreover, widespread pain, cognitive disturbance and anxiety were significantly higher among acne patients compared to healthy individuals. It was found that there was a four times increase in the risk of having fibromyalgia syndrome with the increase in the duration of acne. In addition to that, widespread pain, anxiety and cognitive disturbance increase significantly with the increase in its duration. Conclusions: fibromyalgia syndrome was more common in acne patients and increase with the increase in acne duration.

Keywords


Fibromyalgia Syndrome, Acne Vulgaris, Diffuse Pain Syndrome and Acne Vulgaris, Fibromyalgia and Acne Vulgaris.

References