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Spectrophotometric Quantification of Telmisartan Employing Multivariate Calibration Technique in Bulk and Pharmaceutical Formulations


Affiliations
1 Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603203, India
     

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The present study focuses on the development and validation of an accurate, precise, sensitive and rapid multivariate calibration technique employing UV spectrophotometric method for the quantification of Telmisartan in bulk and pharmaceutical formulation. Multivariate calibration technique utilises the linear regression equations by correlating the relation between concentration and absorbance at five different wavelengths thereby improves the correlation and minimises the instrumental fluctuations. Telmisartan shows absorption maximum at 296 nm in alkaline condition, and good linearity was obtained in the range of 5 - 15 μg/mL. The other parameters were validated and were found to be following ICH guidelines.

Keywords

Telmisartan, Antihypertensive, UV Spectrophotometer, Multivariate Calibration, ICH Guidelines.
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  • Spectrophotometric Quantification of Telmisartan Employing Multivariate Calibration Technique in Bulk and Pharmaceutical Formulations

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Authors

A. Sai Susmitha
Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603203, India
K. S. Kokilambigai
Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603203, India
K. S. Lakshmi
Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603203, India

Abstract


The present study focuses on the development and validation of an accurate, precise, sensitive and rapid multivariate calibration technique employing UV spectrophotometric method for the quantification of Telmisartan in bulk and pharmaceutical formulation. Multivariate calibration technique utilises the linear regression equations by correlating the relation between concentration and absorbance at five different wavelengths thereby improves the correlation and minimises the instrumental fluctuations. Telmisartan shows absorption maximum at 296 nm in alkaline condition, and good linearity was obtained in the range of 5 - 15 μg/mL. The other parameters were validated and were found to be following ICH guidelines.

Keywords


Telmisartan, Antihypertensive, UV Spectrophotometer, Multivariate Calibration, ICH Guidelines.

References