Open Access
Subscription Access
Open Access
Subscription Access
Synthesis, Characterization, Antimicrobial Evaluation of 2-Amino Pyrimidine Schiff Base Derivative
Subscribe/Renew Journal
Schiff base or imine is an analogue of a ketone or aldehyde in which the carbonyl group has been replaced by an imine or azomethine group. Schiff bases exhibits a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties Imine or azomethine groups are present in various natural, natural-derived and non-natural compounds. The imine group present in such compounds has been shown to be critical to their biological activities A new compound (Z)-N_(4-dimethylamino) benzylidene) pyrimidine-2-aminewas synthesized by the reaction of 2-aminopyrimidine, 4-(dimethylamino) benzaldehyde and a drop of acetic acid in the presence of ethanol respectively. The chemical structures of the synthesized compounds were characterised by using Fourier Transform Infra Red Spectroscopy (FTIR), Proton Nuclear Magnetic Resonace Spectroscopy technique (1HNMR). The synthesized compound showed mild antibacterial activity against Staphylococcus aureus and Escherichia coli.
Keywords
Antibacterial, Aromatic Aldehyde, 2-Amino Pyrimdine, Schiffbase, Imine.
Subscription
Login to verify subscription
User
Font Size
Information
- Ashraf M. A., Mahmood K., Wajid A.: Synthesis, Characterization and Biological Activity of Schiff Bases. IPCBEE, 2011, 10, 1–7.
- Kalaivani S., Priya N. P., Arunachalam S.: Schiff bases: facile synthesis, spectral characterization and biocidal studies. IJABPT, 2012, 3, 219–223.
- D.N. Dhar and C.L. Taploo, Schiff bases and their applications, J Sci Ind Res 1982:41 (8); 501–506.
- P. Przybylski, A. Huczynski, K. Pyta, B. Brzezinski and F. Bartl, Biological properties of Schiff bases and azo derivatives of phenols, Curr Org Chem, 2009:13 (2); 124–148.
- G. Bringmann, M. Dreyer, J.H. Faber, P.W. Dalsgaard, D. Staerk and J.W. Jaroszewski et al., Ancistrotanzanine C and related 5, 1′- and 7, 3′-coupled naphthylisoquinoline alkaloids from Ancistrocladustanzaniensis, J Nat Prod, 2004:67 (5); 743–748.
- A.O. de Souza, F.C.S. Galetti, C.L. Silva, B. Bicalho, M.M. Parma and S.F. Fonseca et al., Antimycobacterial and cytotoxicity activity of synthetic and natural compounds, Quim Nova, 2007:30 (7); 1563–1566.
- Z. Guo, R. Xing, S. Liu, Z. Zhong, X. Ji and L. Wang et al., Antifungal properties of Schiff bases of chitosan, N-substituted chitosan and quaternized chitosan, Carbohydr Res, 2007:342 (10); 1329–1332.
- M.J. Hearn and M.H. Cynamon, Design and synthesis of antituberculars: preparation and evaluation against Mycobacterium tuberculosis of an isoniazid Schiff base, J Antimicrob Chemother 2004:53 (2); 185–191.
- S.Ramachandran and P. Shanmugapandiyan , Synthesis, Characterisation, antimicrobial evaluation of Thiazolidine -4-one derivatives IJPI”s Journal of Medicinal Chemistry, 2010:1(1); 1-6
- S. Ramachandran, S. Abdul Rahman, Jiwan Kumar Basnet, M. Kamarudeen, S. A. Shahina, P. Shanmugapandiyan, Synthesis, Characterisation, Antimicrobial evaluation of Thiazolidine-4-one derivative, World Journal of Pharmacy and Pharmaceutical Sciences, 2013:2(1); 337-342.
- S. Ramachandran, M. A. Rizwanullah, Santhiya T, Senthil Kumar. D, Sandeep Kumar, Dr. N. Deepa and Dr. R. Sundhararajan, Synthesis, Characterisation, Antimicrobial evaluation of 2-oxoazetidine derivative, World Journal of Pharmacy and Pharmaceutical Sciences 2015:4(7); 324-329.
- S. H. Gillespie; .Medical Microbiology-Illustrated., Butterworth Heinemann Ltd., United Kingdom, 1994; 234- 247.
- Bentley’s textbook of Pharmaceutics, Eighth edition, 1996; 596-597.
- Indian Pharmacopoeia, A-1996; 100, 105.
Abstract Views: 195
PDF Views: 0